Nutritional supplements like Bergamot have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Bergamot supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Bergamot supplements can benefit Rosai-Dorfman disease patients on Cladribine cancer treatment. But avoid Bergamot supplements if on Cyclophosphamide treatment for Chronic Myeloid Leukemia. Similarly, taking the nutritional supplement Bergamot can benefit healthy individuals who are at genetic risk of cancer due to mutation of the gene CDKN1B. But avoid taking nutritional supplement Bergamot when at genetic risk of cancer due to mutation of gene MRE11.
The takeaway being – your individual context will influence your decision if nutritional supplement Bergamot is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Bergamot based on individual context and conditions.
So the question is should you take the supplement Bergamot? Should you take it when at genetic risk of cancer for mutation of gene MRE11? Should you take it when at genetic risk of cancer for mutation of gene CDKN1B? Should you take it when diagnosed with Chronic Myeloid Leukemia? Should you take Bergamot supplements when diagnosed with Rosai-Dorfman disease? Should you take it when on Cyclophosphamide treatment? Should you continue taking Bergamot supplements if you change your treatment from Cyclophosphamide to Cladribine? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Bergamot.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Chronic Myeloid Leukemia or Rosai-Dorfman disease, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Bergamot.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Bergamot? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene MRE11 the same as due to mutation of gene CDKN1B? Are the implications of taking Bergamot supplements in Chronic Myeloid Leukemia the same as Rosai-Dorfman disease? Is it one and the same if you are on treatment with Cyclophosphamide or on Cladribine?
Bergamot – A Nutritional Supplement
Bergamot, also known as Citrus bergamia or Bergamot orange, is a citrus fruit native to southern Italy. The peel of the fruit as well as the fruit extract are considered to have medicinal properties. Edible Bergamot oil is also used as a flavoring agent in foods and drinks. Following are some of the potential health benefits of Bergamot:
- May help reduce bad cholesterol levels (Rosaria Vincenza Giglio et al, Phytomedicine., 2016; Mirielle C Nauman and Jeremy J Johnson, Integr Food Nutr Metab., 2019)
- May help reduce inflammation and glucose levels (Simone Perna et al, Food Sci Nutr., 2019)
Bergamot supplements contain many active ingredients including Bergapten, Beta-bourbonene, Butyric Acid, Carvacrol, Myrcene, Thymoquinone, Naringin, Rutin and Tangeretin at different concentration levels. The molecular pathways which are regulated by Bergamot include Oxidative Stress, RAS-RAF Signaling, Estrogen Signaling, FOXO Signaling and Vitamin Metabolism. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Bergamot individually or in combination is an important decision to be made. When making decisions on the use of supplement Bergamot for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Bergamot use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Bergamot Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Bergamot for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Bergamot may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Bergamot should be avoided or not and why.
1. Will Bergamot Supplements benefit Cancer Patients with Chronic Myeloid Leukemia Patients undergoing Cyclophosphamide treatment?
Chronic Myeloid Leukemia is characterized and driven by specific genetic mutations like BCR-ABL1 and RUNX1 leading to biochemical pathway changes in Oxidative Stress, Vitamin Metabolism, Growth Factor Signaling, Cancer Epigenetics and RUNX Signaling. A cancer treatment like Cyclophosphamide works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Bergamot should be avoided for Chronic Myeloid Leukemia along with treatment of Cyclophosphamide. Bergamot impacts pathways/processes like Oxidative Stress and Vitamin Metabolism which either promote drivers of the disease and/or nullify the treatment effect. Additionally, Bergamot contains many active ingredients such as Myrcene, Thymoquinone, Bergapten, Naringin, Rutin and Tangeretin which have CYP3A4 or CYP2B6 (drug metabolizing enzyme) interactions with Cyclophosphamide treatment and hence should be avoided by patients undergoing this treatment. (https://patents.google.com/patent/US7169763B2/en; Ahmed A Albassam et al, Saudi Pharm J., 2018; P C Ho et al, J Pharm Pharm Sci., Sep-Dec 2001; Sedar Karakurt, Acta Pharm., 2016; Darija Šarić Mustapić et al, Molecules., 2018) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Bergamot Supplements benefit Rosai-Dorfman disease Patients undergoing Cladribine Cancer Treatment?
Rosai-Dorfman disease is characterized and driven by specific genetic mutations like KRAS and MAP2K1 leading to biochemical pathway changes in RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, MYC Signaling and MAPK Signaling. A cancer treatment like Cladribine works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Bergamot supplements should be considered for Rosai-Dorfman disease along with treatment Cladribine. Bergamot supplement impacts pathways/processes like RAS-RAF Signaling and PI3K-AKT-MTOR Signaling which either obstruct drivers of Rosai-Dorfman disease and/or improve Cladribine treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Bergamot Supplements Safe for Healthy Individuals with MRE11 Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. MRE11 is one of the genes generally available in panels for cancer risk testing.
MRE11 mutation causes biochemical pathways/processes like Estrogen Signaling, DNA Repair, Stem Cell Signaling, Interferon Signaling and Angiogenesis to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Bergamot should be avoided when the genetic panel identifies mutation of MRE11 for Breast Cancer. Bergamot impacts pathways/processes like Estrogen Signaling and DNA Repair and creates adverse effects with MRE11 and related conditions.
4. Are Bergamot Supplements Safe for Healthy Individuals with CDKN1B Mutation Associated Genetic Risk?
CDKN1B is one of the genes available in panels for cancer risk testing. CDKN1B mutation causes biochemical pathways/processes like FOXO Signaling, Cell Cycle Checkpoints, Stem Cell Signaling, PI3K-AKT-MTOR Signaling and Angiogenesis to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Bergamot supplements when the genetic panel identifies mutation in CDKN1B mutation for Neuroendocrine Cancer. Bergamot impacts pathways/processes like FOXO Signaling and Cell Cycle Checkpoints and creates a supportive effect in those with CDKN1B mutation and related conditions.
* Other Factors are also included like BMI, Treatments, Lifestyle Habits
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition, which includes food and nutritional supplements like Bergamot, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.