Nutritional supplements like Evodia have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Evodia supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Evodia supplements can benefit cancer patients with Renal Non-Clear Cell Carcinoma on Bevacizumab treatment. But avoid Evodia supplements if on Imatinib treatment for BCR ABL Negative Chronic Myeloid Leukaemia. Similarly, taking nutritional supplement Evodia can benefit healthy individuals who are at genetic risk of cancer due to mutation of the gene MET. But avoid taking nutritional supplement Evodia when at genetic risk of cancer due to mutation of gene TERT.
The takeaway being – your individual context will influence your decision if nutritional supplement Evodia is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Evodia based on individual context and conditions.
So the question is should you take the supplement Evodia? Should you take it when at genetic risk of cancer for mutation of gene TERT? Should you take it when at genetic risk of cancer for mutation of gene MET? Should you take it when diagnosed with BCR ABL Negative Chronic Myeloid Leukaemia? Should you take Evodia supplements when diagnosed with Renal Non-Clear Cell Carcinoma? Should you take it when on Imatinib treatment? Should you continue taking Evodia supplements if you change your treatment from Imatinib to Bevacizumab? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Evodia.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as BCR ABL Negative Chronic Myeloid Leukaemia or Renal Non-Clear Cell Carcinoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Evodia.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Evodia? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene TERT the same as due to mutation of gene MET? Are the implications of taking Evodia supplements in BCR ABL Negative Chronic Myeloid Leukaemia the same as Renal Non-Clear Cell Carcinoma? Is it one and the same if you are on treatment Imatinib or on Bevacizumab?
Evodia – A Nutritional Supplement
Evodia (Evodia rutaecarpa) or Wuzhuyu is a seasonal tree that is native to China and Korea. The reddish-brown fruit of Evodia has been used for thousands of years in Traditional Chinese Medicine and has a warm, bitter taste. Following are some of the purported uses/health benefits of Evodia: (Jyh-Fei Liao et al, Chin Med., 2011)
- May have strong antioxidant properties
- May help decrease pain and swelling/inflammation
- May help lower blood pressure
- May help reduce diarrhea
- May promote heart health
Evodia supplements contain many active ingredients including Evodiamine at different concentration levels. The molecular pathways which are regulated by Evodia include Cancer Epigenetics, Extracellular Matrix Remodelling, DNA Repair, TGFB Signaling and Apoptosis. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Evodia individually or in combination is an important decision to be made. When making decisions on the use of supplement Evodia for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Evodia use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Evodia Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Evodia for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Evodia may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Evodia should be avoided or not and why.
1. Will Evodia Supplements benefit Cancer Patients with BCR ABL Negative Chronic Myeloid Leukaemia undergoing Imatinib treatment?
BCR ABL Negative Chronic Myeloid Leukaemia is characterized and driven by specific genetic mutations like RUNX1 and ASXL1 leading to biochemical pathway changes in Cancer Epigenetics, RUNX Signaling and Small Molecule Transport. A cancer treatment like Imatinib works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Evodia supplements should be avoided for BCR ABL Negative Chronic Myeloid Leukaemia along with treatment Imatinib. Evodia supplement impacts pathways/processes like Cancer Epigenetics which either promote drivers of the disease and/or nullify the treatment effect. Additionally, Evodia supplement has active ingredients such as Evodiamine which has CYP3A4 interactions with Imatinib treatment and hence should be avoided by patients undergoing this treatment.(Bo Wen et al, Drug Metab Dispos., 2014) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Evodia Supplements benefit Cancer Patients with Renal Non-Clear Cell Carcinoma undergoing Bevacizumab Treatment?
Renal Non-Clear Cell Carcinoma is characterized and driven by specific genetic mutations like MUC16 and TP53 leading to biochemical pathway changes in Extracellular Matrix Remodelling, TGFB Signaling, PI3K-AKT-MTOR Signaling, Small Molecule Transport and MAPK Signaling. A cancer treatment like Bevacizumab works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Evodia supplements should be considered for Renal Non-Clear Cell Carcinoma along with treatment Bevacizumab. Evodia supplement impacts pathways/processes like Extracellular Matrix Remodelling and TGFB Signaling which either obstruct drivers of Renal Non-Clear Cell Carcinoma and/or improve Bevacizumab treatment effect.
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3. Are Evodia Supplements Safe for Healthy Individuals with TERT Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. TERT is one of the genes generally available in panels for cancer risk testing.
TERT mutation causes biochemical pathways/processes like DNA Repair, Apoptosis, RUNX Signaling, Stem Cell Signaling and Cell Cycle Checkpoints to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Evodia should be avoided when the genetic panel identifies mutation of TERT for Hematological Cancer. Evodia impacts pathways/processes like DNA Repair and Apoptosis and creates adverse effects with TERT and related conditions.
4. Are Evodia Supplements Safe for Healthy Individuals with MET Mutation Associated Genetic Risk?
MET is one of the genes available in panels for cancer risk testing. MET mutation causes biochemical pathways/processes like Extracellular Matrix Remodelling, PI3K-AKT-MTOR Signaling, Stem Cell Signaling, RAS-RAF Signaling and Adherens junction to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Evodia supplements when the genetic panel identifies mutations in MET for Kidney Cancer. Evodia impacts pathways/processes like Extracellular Matrix Remodelling and PI3K-AKT-MTOR Signaling and creates a supportive effect in those with MET mutation and related conditions.
* Other Factors are also included like BMI, Treatments, Lifestyle Habits
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition, which includes food and nutritional supplements like Evodia, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.