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Clinical Benefits of Lycopene in Cancer Patients

Jul 5, 2021

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Eating a diet rich in tomatoes, a source of a powerful antioxidant red pigment carotenoid, lycopene, has many health benefits including improved efficacy of docetaxel in castration resistant prostate cancer. Another clinical study has shown that lycopene (found in tomatoes and other foods) supplement can reduce the cisplatin-induced kidney damage (a chemotherapy side effect associated with use of Cisplatin) – a potential natural remedy for cancer treatment induced side effect. Including tomatoes and foods rich in lycopene as part of prostate cancer patients’ diet may be beneficial.


Eating healthier by eating a lot more fruits and vegetables is obviously important for maintaining good health, but clinical research has explicitly evaluated if consuming specific foods can help with either lowering cancer risk or improving the effect of certain chemotherapy drugs on specific cancers. Studies have been done to evaluate the clinical benefits of Lycopene in cancer. Lycopene is a natural red pigment, a carotenoid, that is part of fruits and vegetables, that most of us do not know much about despite consuming it almost on a daily basis. We all eat tomatoes as part of our diets and tomatoes get their red color due to being a rich source of lycopene.

Lycopene Use in Cancer Patients (Tomatoes for kidney damage)

General Health Benefits of Lycopene

Lycopene is a powerful antioxidant with many health benefits. Following are some of the potential health benefits of Lycopene:

Additionally, lycopene has benefits in prostate cancer patients which is elaborated later in this blog.

The dosage for Lycopene Supplement Capsules range from 10-30 mg twice daily orally.

Excess intake of lycopene supplements may lead to certain side effects like skin discoloration, nausea, bloating and diarrhea. Pregnant women should avoid taking lycopene supplements.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Benefits of taking Lycopene Rich Foods/Supplements by Prostate Cancer Patients

Prostate cancer is a very common cancer among men. This type of cancer is heightened or fueled by testosterone and other male sex hormones which is why the therapy for prostate cancer involves lowering the hormone level in the patient by chemical or surgical means. However, if the cancer is able to metastasize and spread through more parts of the body, then the cancer is called castrate resistant prostate cancer (CRPC) because in this case, lowering the patient’s sex hormone count will have no antitumor effect on the growing cancer. The current most effective drug for CRPC on the market is a chemo drug called Docetaxel, but even then, it is only able to increase patient lifespans by an average of two months.

In 2011, a study was done by researchers from the University of California, Irvine, testing out how carotenoids such as lycopene could enhance the effect of Docetaxel (DTX/DXL) on prostate cancer. The researchers found that lycopene supplement along with docetaxel had more pronounced growth inhibitory effects than that of docetaxel treatment alone. Lycopene significantly enhanced the antitumor efficacy of docetaxel by approximately 38% suggesting that lycopene supplements and lycopene rich foods may be beneficial for prostate cancer patients. (Tang Y et al, Neoplasia, 2011) In recent years, additional studies have confirmed the results of this study to be accurate and also shown benefits of a reduced risk of prostate cancer with higher lycopene consumption. (Chen P et al, Medicine (Baltimore), 2015)

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Effect of Lycopene on Cisplatin-Induced Nephrotoxicity (Kidney Damage)

Another study conducted in 2017 by researchers from the Shahrekord University of Medical Sciences in Iran looked at the effects that lycopene (found in tomatoes) could have on cisplatin induced kidney damage (nephropathy) in patients. Cisplatin is a strong, toxic chemotherapy drug which is used to treat multiple cancers. However, since this drug affects both cancer and non cancer cells, it has to be used in limited doses otherwise it can cause other major health problems in the body. One common side effect of Cisplatin is nephropathy, which is caused by damage to blood vessels inside the kidney. Therefore, the researchers of the study wanted to see if lycopene was able to decrease this toxic effect of a drug like cisplatin. After conducting a double-blind randomized trial, by splitting 120 patients into two groups, they found that “Lycopene (from tomatoes) can be effective in decreasing the complications due to cisplatin-induced nephrotoxicity (kidney damage) through affecting some markers of renal function” (Mahmoodnia L et al, J Nephropathol. 2017).


In conclusion, patients with prostate cancer or who are currently going through chemotherapy involving the drug Cisplatin should consider increasing their consumptions of lycopene rich red vegetables, especially tomatoes, in order to potentially aid their recovery and better their chances of survival.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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