Nutritional supplements like Rye have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Rye supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Rye supplements can benefit cancer patients with B Cell Acute Lymphoblastic Leukemia on CAR-T treatment. But avoid Rye supplements if on Prednisone treatment for Rosai-Dorfman disease. Similarly, taking nutritional supplement Rye can benefit healthy individuals who are at genetic risk of cancer due to mutation of the gene CDKN2A. But avoid taking nutritional supplement Rye when at genetic risk of cancer due to mutation of gene TERT.
The takeaway being – your individual context will influence your decision if nutritional supplement Rye is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Rye based on individual context and conditions.
So the question is should you take supplement Rye? Should you take it when at genetic risk of cancer for mutation of gene TERT? Should you take it when at genetic risk of cancer for mutation of gene CDKN2A? Should you take it when diagnosed with Rosai-Dorfman disease? Should you take Rye supplements when diagnosed with B Cell Acute Lymphoblastic Leukemia? Should you take it when on Prednisone treatment? Should you continue taking Rye supplements if you change your treatment from Prednisone to CAR-T? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Rye.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Rosai-Dorfman disease or B Cell Acute Lymphoblastic Leukemia, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Rye.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Rye? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene TERT the same as due to mutation of gene CDKN2A? Are the implications of taking Rye supplements in Rosai-Dorfman disease the same as B Cell Acute Lymphoblastic Leukemia? Is it one and the same if you are on treatment Prednisone or on CAR-T?
Rye – A Nutritional Supplement
Rye or Secale cereale, is a plant that belongs to the family Poaceae. Rye is usually grown for its grain. It is rich in dietary fiber, minerals and vitamins and has antioxidant properties. Following are some of the potential health benefits of Rye:
May help reduce blood sugar (B Hagander et al, Diabetes Res Clin Pract., Mar-Apr 1987)
May help reduce bad cholesterol and improve heart health (K S Leinonen et al, J Nutr., 2000)
May help improve digestive system health (Graeme H McIntosh et al, Am J Clin Nutr., 2003)
May help reduce the risk of gallstones (J X Zhang et al, APMIS., 1992)
May help reduce inflammation (Petteri Kallio et al, Am J Clin Nutr., 2008)
However, excess intake of rye can cause some side effects like bloating. Also, Rye contains phytic acid which obstructs the absorption of nutrient minerals like iron and zinc.
Rye supplements contain many active ingredients including Beta-sitosterol, Oleic Acid and P-coumaric Acid at different concentration levels. The molecular pathways which are regulated by Rye include MYC Signaling, B Cell Receptor Signaling, Stem Cell Signaling, Cell Cycle Checkpoints and MAPK Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Rye individually or in combination is an important decision to be made. When making decisions on the use of supplement Rye for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Rye use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Rye Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Rye for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Rye may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Rye should be avoided or not and why.
1. Will Rye Supplements benefit Rosai-Dorfman disease Patients undergoing Prednisone Cancer treatment?
Rosai-Dorfman disease is characterized and driven by specific genetic mutations like KRAS and MAP2K1 leading to biochemical pathway changes in MYC Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling. A cancer treatment like Prednisone works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Rye should be avoided for Rosai-Dorfman disease along with treatment Prednisone. Rye impacts pathways/processes like MYC Signaling and MAPK Signaling which either promote drivers of the disease and/or nullify the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Rye Supplements benefit Cancer Patients with B Cell Acute Lymphoblastic Leukemia undergoing CAR-T Treatment?
B Cell Acute Lymphoblastic Leukemia is characterized and driven by specific genetic mutations like TP53 and KMT2D leading to biochemical pathway changes in B Cell Receptor Signaling, PI3K-AKT-MTOR Signaling, Lipid Metabolism, MYC Signaling and MAPK Signaling. A cancer treatment like CAR-T works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Rye supplements should be considered for B Cell Acute Lymphoblastic Leukemia along with treatment CAR-T. Rye supplement impacts pathways/processes like B Cell Receptor Signaling and PI3K-AKT-MTOR Signaling which either obstruct drivers of B Cell Acute Lymphoblastic Leukemia and/or improve CAR-T treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Rye Supplements Safe for Healthy Individuals with TERT Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. TERT is one of the genes generally available in panels for cancer risk testing.
TERT mutation causes biochemical pathways/processes like Stem Cell Signaling, Cell Cycle Checkpoints, RUNX Signaling, JAK-STAT Signaling and Hypoxia to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Rye should be avoided when the genetic panel identifies mutation of TERT for Hematological Cancer. Rye impacts pathways/processes like Stem Cell Signaling and Cell Cycle Checkpoints and creates adverse effects with TERT and related conditions.
4. Are Rye Supplements Safe for Healthy Individuals with CDKN2A Mutation Associated Genetic Risk?
CDKN2A is one of the genes available in panels for cancer risk testing. CDKN2A mutation causes biochemical pathways/processes like Cell Cycle Checkpoints, P53 Signaling, Stem Cell Signaling, Angiogenesis and DNA Repair to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Rye supplements when the genetic panel identifies mutation in CDKN2A for Skin Cancer and Head And Neck Squamous Cell Carcinoma. Rye impacts pathways/processes like Cell Cycle Checkpoints and P53 Signaling and creates a supportive effect in those with CDKN2A mutation and related conditions.
* Other Factors are also included like BMI, Treatments, Lifestyle Habits
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Rye, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.