Nutritional supplements like Pterostilbene have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Pterostilbene supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Pterostilbene supplements can benefit Relapsed Refractory Diffuse Large B-Cell Lymphoma (RR-DLBCL) patients on Prednisone cancer treatment. But avoid Pterostilbene supplements if on Etoposide treatment for Pineoblastoma. Similarly, taking nutritional supplement Pterostilbene can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene MAX. But avoid taking nutritional supplement Pterostilbene when at genetic risk of cancer due to mutation of gene TERT.
The takeaway being – your individual context will influence your decision if nutritional supplement Pterostilbene is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Pterostilbene based on individual context and conditions.
So the question is should you take the supplement Pterostilbene? Should you take it when at genetic risk of cancer for mutation of gene TERT? Should you take it when at genetic risk of cancer for mutation of gene MAX? Should you take it when diagnosed with Pineoblastoma? Should you take Pterostilbene supplement when diagnosed with Relapsed Refractory Diffuse Large B-Cell Lymphoma (RR-DLBCL)? Should you take it when on Etoposide treatment? Should you continue taking Pterostilbene supplement if you change your treatment from Etoposide to Prednisone? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Pterostilbene.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Pineoblastoma or Relapsed Refractory Diffuse Large B-Cell Lymphoma (RR-DLBCL), the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Pterostilbene.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Pterostilbene? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene TERT the same as due to mutation of gene MAX? Are the implications of taking Pterostilbene supplement in Pineoblastoma the same as Relapsed Refractory Diffuse Large B-Cell Lymphoma (RR-DLBCL)? Is it one and the same if you are on treatment with Etoposide or on Prednisone?
Pterostilbene – A Nutritional Supplement
Pterostilbene is a natural derivative of Resveratrol with structural resemblance. It has a powerful antioxidant effect and prevents the cells from the damaging effects of reactive oxygen species. The use of Pterostilbene supplement may lead to the following health benefits: (Hyunsook Kim at al, J Agric Food Chem. 2020)
- May control high cholesterol level
- May help in weight management
- May show anti-inflammatory and neuroprotective effects (Pablo Peñalver et al, J Agric Food Chem. 2020)
- May prevent cancer progression (Denise McCormack et al, J Surg Res. 2012)
- May control high blood sugar (Yu Jing Zhang et al, Biomed Environ Sci. 2020)
- May prevent atherosclerosis (Wei Wang et al, J Agric Food Chem. 2019)
Pterostilbene is an active ingredient found in various food items. Coffee, Blueberry and Grape contain Pterostilbene at different concentration levels along with other active ingredients. The molecular pathways which are regulated by Pterostilbene include RUNX Signaling, Epithelial to Mesenchymal Transition, Cytokine Signaling, Stem Cell Signaling and DNA Repair. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Pterostilbene individually or in combination is an important decision to be made. When making decisions on the use of supplement Pterostilbene for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Pterostilbene use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Pterostilbene Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Pterostilbene for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Pterostilbene may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Pterostilbene should be avoided or not and why.
1. Will Pterostilbene Supplements benefit Cancer Patients with Pineoblastoma undergoing Etoposide treatment?
Pineoblastoma is characterized and driven by specific genetic mutations like ATR and ATM leading to biochemical pathway changes in RUNX Signaling, DNA Repair, Notch Signaling, EPHRIN Signaling and PI3K-AKT-MTOR Signaling. A cancer treatment like Etoposide works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Pterostilbene supplement should be avoided for Pineoblastoma along with treatment Etoposide. Pterostilbene supplement impacts pathways/processes like DNA Repair which either promote drivers of the Pineoblastoma and/or nullify the treatment effect. Additionally, Pterostilbene supplement has CYP1A1/2 interaction with the Etoposide treatment, and hence should be avoided. (Pius S. Fasinu et al, Front Oncol., 2019; A A Albassam at al, Pharmazie. 2021; Pubchem Assay) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Pterostilbene Supplements benefit Cancer Patients with Relapsed Refractory Diffuse Large B-Cell Lymphoma (RR-DLBCL) undergoing Prednisone Treatment?
Relapsed Refractory Diffuse Large B-Cell Lymphoma (RR-DLBCL) is characterized and driven by specific genetic mutations like CREBBP and KMT2D leading to biochemical pathway changes in Epithelial to Mesenchymal Transition, NFKB Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling. A cancer treatment like Prednisone works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Pterostilbene supplement should be considered for Relapsed Refractory Diffuse Large B-Cell Lymphoma (RR-DLBCL) along with treatment Prednisone. Pterostilbene supplement impacts pathways/processes like Epithelial to Mesenchymal Transition and NFKB Signaling which either obstruct drivers of Relapsed Refractory Diffuse Large B-Cell Lymphoma (RR-DLBCL) and/or improve Prednisone treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Pterostilbene Supplements Safe for Healthy Individuals with TERT Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. TERT is one of the genes generally available in panels for cancer risk testing.
TERT mutation causes biochemical pathways/processes like Cytokine Signaling, MYC Signaling, Nucleotide metabolism, Stem Cell Signaling and Hypoxia to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Pterostilbene supplement should be avoided when the genetic panel identifies mutation of TERT for Hematological Cancer. Pterostilbene supplement impacts pathways/processes like Cytokine Signaling and MYC Signaling and creates adverse effects with TERT and related conditions.
4. Are Pterostilbene Supplements Safe for Healthy Individuals with MAX Mutation Associated Genetic Risk?
MAX is one of the genes available in panels for cancer risk testing. MAX mutation causes biochemical pathways/processes like Stem Cell Signaling, MAPK Signaling, Cell Cycle, MYC Signaling and Angiogenesis to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Pterostilbene supplement when the genetic panel identifies mutation in MAX for Neuroendocrine Cancer. Pterostilbene supplement impacts pathways/processes like MYC Signaling, Stem Cell Signaling and MAPK Signaling and creates a supportive effect in those with MAX mutation and related conditions.
* Other Factors are also included like BMI, Lifestyle Habits, Treatments
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition, which includes food and nutritional supplements like Pterostilbene, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.