Nutritional supplements like Polydatin have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Polydatin supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Polydatin supplements can benefit cancer patients with Richter Syndrome on Cyclophosphamide treatment. But avoid Polydatin supplements if on Tamoxifen treatment for ER PR Positive HER2 Negative Breast Carcinoma. Similarly, taking nutritional supplement Polydatin can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene MAX. But avoid taking nutritional supplement Polydatin when at genetic risk of cancer due to mutation of gene NBN.
The takeaway being – your individual context will influence your decision if nutritional supplement Polydatin is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Polydatin based on individual context and conditions.
So the question is should you take supplement Polydatin? Should you take it when at genetic risk of cancer for mutation of gene NBN? Should you take it when at genetic risk of cancer for mutation of gene MAX? Should you take it when diagnosed with ER PR Positive HER2 Negative Breast Carcinoma? Should you take Polydatin supplement when diagnosed with Richter Syndrome? Should you take it when on Tamoxifen treatment? Should you continue taking Polydatin supplement if you change your treatment from Tamoxifen to Cyclophosphamide? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Polydatin.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as ER PR Positive HER2 Negative Breast Carcinoma or Richter Syndrome, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Polydatin.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Polydatin? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene NBN the same as due to mutation of gene MAX? Are the implications of taking Polydatin supplement in ER PR Positive HER2 Negative Breast Carcinoma the same as Richter Syndrome? Is it one and the same if you are on treatment with Tamoxifen or on Cyclophosphamide?
Polydatin – A Nutritional Supplement
Polydatin is an active compound majorly derived from Polygonum cuspidatum and is also found in many other plants. It is considered as a precursor molecule for Resveratrol and has many protective effects. The health benefits of consuming Polydatin supplements are:
- Reduces Atherosclerosis and related cardiovascular disorder (Yi Peng at al, Phytomedicine. 2019; )
- Possesses antioxidant and anti-inflammatory effect (Lina Gu at al, Microb Pathog. 2019)
- Possesses neuroprotective effect (Youguang Gao at al, Mol Med Rep. 2016)
- Reduces melanin production in skin (Jeong ET et al, Arch Pharm Res. 2010)
- Possesses anticancer effect (Yaodong Chen et al, Life Sci. 2020)
- Has protective effect against liver injuries (Hong Zhang at al, PLoS One. 2012)
- Shows radioprotective effect and prevents lung injury (Kun Cao at al, J Cell Mol Med. 2017)
Polydatin is an active ingredient found in various food items. Grape and Peanuts contain Polydatin at different concentration levels along with other active ingredients. The molecular pathways which are regulated by Polydatin include Estrogen Signaling, NFKB Signaling, Cell Cycle Checkpoints, Cell Cycle and MYC Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Polydatin individually or in combination is an important decision to be made. When making decisions on the use of supplement Polydatin for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Polydatin use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Polydatin Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Polydatin for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Polydatin may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Polydatin should be avoided or not and why.
1. Will Polydatin Supplements benefit Cancer Patients with ER PR Positive HER2 Negative Breast Carcinoma undergoing Tamoxifen treatment?
ER PR Positive HER2 Negative Breast Carcinoma is characterized and driven by specific genetic mutations like ESR1 and NR3C3 leading to biochemical pathway changes in Estrogen Signaling, PI3K-AKT-MTOR Signaling and Inositol Phosphate Signaling. A cancer treatment like Tamoxifen works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Polydatin supplement should be avoided for ER PR Positive HER2 Negative Breast Carcinoma along with treatment Tamoxifen. Polydatin supplement impacts pathways/processes like Estrogen Signaling which either promote drivers of the ER PR Positive HER2 Negative Breast Carcinoma and/or nullify the treatment effect. Additionally, Polydatin supplement has CYP1A1 interaction with Tamoxifen treatment, and hence should be avoided. (Ramya Krishna Vadlapatla at al, Curr Pharm Des. 2013; Manuela Martano at al, Oncol Rep. 2018) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Polydatin Supplements benefit Cancer Patients with Richter Syndrome undergoing Cyclophosphamide Treatment?
Richter Syndrome is characterized and driven by specific genetic mutations like MYC and TRAF3 leading to biochemical pathway changes in NFKB Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling and MYC Signaling. A cancer treatment like Cyclophosphamide works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Polydatin supplement should be considered for Richter Syndrome along with treatment Cyclophosphamide. Polydatin supplement impacts pathways/processes like NFKB Signaling and Cell Cycle which either obstruct drivers of Richter Syndrome and/or improve Cyclophosphamide treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Polydatin Supplements Safe for Healthy Individuals with NBN Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. NBN is one of the genes generally available in panels for cancer risk testing.
NBN mutation causes biochemical pathways Cell Cycle Checkpoints, Estrogen Signaling, Stem Cell Signaling, DNA Repair and Angiogenesis to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Polydatin supplement should be avoided when the genetic panel identifies mutation of NBN for Breast Cancer. Polydatin supplement impacts pathways/processes like Estrogen Signaling and creates adverse effects with NBN and related conditions.
4. Are Polydatin Supplements Safe for Healthy Individuals with MAX Mutation Associated Genetic Risk?
MAX is one of the genes available in panels for cancer risk testing. MAX mutation causes biochemical pathways/processes like Cell Cycle, MYC Signaling, Stem Cell Signaling, MAPK Signaling and Angiogenesis to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Polydatin supplement when the genetic panel identifies mutation in MAX for Neuroendocrine Cancer. Polydatin supplement impacts pathways/processes like Cell Cycle and MYC Signaling and creates a supportive effect in those with MAX mutation and related conditions.
* Other Factors are also included like BMI, Lifestyle Habits, Treatments
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Polydatin, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.