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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

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For Which Cancer Types Should I Avoid Myricetin Supplement?

Jun 18, 2021

Estimated reading time: 9 minutes
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Highlights

Nutritional supplements like Myricetin have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Myricetin supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.

Taking nutritional Myricetin supplements can benefit cancer patients with Renal Non-Clear Cell Carcinoma on Bevacizumab treatment. But avoid Myricetin supplements if on Imatinib treatment for BCR ABL Negative Chronic Myeloid Leukemia. Similarly, taking nutritional supplement Myricetin can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene MLH1. But avoid taking nutritional supplement Myricetin when at genetic risk of cancer due to mutation of gene MRE11.

The takeaway being – your individual context will influence your decision if nutritional supplement Myricetin is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.



Brief Overview

Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements  are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose  the right combination of supplements like Myricetin based on individual context and conditions.

Myricetin Supplements for Cancer Treatment and Genetic Risk

So the question is should you take supplement Myricetin? Should you take it when at genetic risk of cancer for mutation of gene MRE11? Should you take it when at genetic risk of cancer for mutation of gene MLH1? Should you take it when diagnosed with BCR ABL Negative Chronic Myeloid Leukemia? Should you take Myricetin supplement when diagnosed with Renal Non-Clear Cell Carcinoma? Should you take it when on Imatinib treatment? Should you continue taking it if you change your treatment from Imatinib to Bevacizumab? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Myricetin. 

Cancer

Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as BCR ABL Negative Chronic Myeloid Leukemia or Renal Non-Clear Cell Carcinoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Myricetin.

So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Myricetin? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene MRE11 the same as due to mutation of gene MLH1? Are the implications of BCR ABL Negative Chronic Myeloid Leukemia same as Renal Non-Clear Cell Carcinoma? Is it one and the same if you are on treatment with Imatinib or on Bevacizumab? 

Myricetin – A Nutritional Supplement

Myricetin is a bioflavonoid derived from plants which has nutraceutical value. It is one of the key active ingredients of many foods. The health benefits of consuming Myricetin as supplement are :

Myricetin is an active ingredient found in various food items. Bilberry, Blackberry and Blueberry contain Myricetin at different concentration levels along with other active ingredients. The molecular pathways which are regulated by Myricetin include Cancer Epigenetics, Epithelial to Mesenchymal Transition, DNA Repair, Nucleotide metabolism and Oxidative Stress. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Myricetin individually or in combination is an important decision to be made. When making decisions on the use of supplement Myricetin for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Myricetin use cannot be a one-size-fits-all decision for all types of cancers.

Choosing Myricetin Supplements for Your Cancer

The reason there is no easy way to answer the question “When should I avoid Myricetin for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Myricetin may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Myricetin should be avoided or not and why.

1. Will Myricetin Supplements benefit Cancer Patients with BCR ABL Negative Chronic Myeloid Leukemia undergoing Imatinib treatment?

BCR ABL Negative Chronic Myeloid Leukemia is characterized and driven by specific genetic mutations like RUNX1 and ASXL1 leading to biochemical pathway changes in Cancer Epigenetics, RUNX Signaling and Small Molecule Transport. A cancer treatment like Imatinib works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Myricetin supplement should be avoided for BCR ABL Negative Chronic Myeloid Leukemia along with treatment Imatinib. Myricetin supplement impacts pathways/processes like Cancer Epigenetics which either promote drivers of the BCR ABL Negative Chronic Myeloid Leukemia and/or nullify the treatment effect.  Additionally, Myricetin has CYP3A4 interaction with the Imatinib treatment, and hence should be avoided. (Food and Drug Administration, Drug Interactions Flockhart Table, Yannan Li et al, Toxicol Lett. 2018) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).

2. Will Myricetin Supplements benefit Cancer Patients with Renal Non-Clear Cell Carcinoma undergoing Bevacizumab Treatment?

Renal Non-Clear Cell Carcinoma is characterized and driven by specific genetic mutations like MUC16 and TP53 leading to biochemical pathway changes in Epithelial to Mesenchymal Transition, Cytoskeletal Dynamics, Hypoxia, Small Molecule Transport and PI3K-AKT-MTOR Signaling. A cancer treatment like Bevacizumab works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Myricetin supplement should be considered for Renal Non-Clear Cell Carcinoma along with treatment Bevacizumab. Myricetin supplement impacts pathways/processes like Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling which either obstruct drivers of the Renal Non-Clear Cell Carcinoma and/or improve the treatment effect.

For Which Cancer to Avoid taking Supplement Myricetin

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Are Myricetin Supplements Safe for Healthy Individuals with MRE11 Mutation Associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. MRE11 is one of the genes generally available in panels for cancer risk testing.

MRE11 mutation causes biochemical pathways DNA Repair, Stem Cell Signaling, Estrogen Signaling, Angiogenesis and Growth Factor Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Myricetin supplements should be avoided when the genetic panel identifies mutation of MRE11 for Breast Cancer. Myricetin supplement impacts pathways/processes like DNA Repair and creates adverse effects with MRE11 and related conditions.

4. Are Myricetin Supplements Safe for Healthy Individuals with MLH1 Mutation Associated Genetic Risk?

MLH1 is one of the genes available in panels for cancer risk testing. MLH1 mutation causes biochemical pathways Nucleotide metabolism, Estrogen Signaling, Stem Cell Signaling, P53 Signaling and NFKB Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Myricetin supplement when the genetic panel identifies mutation in MLH1 for Ovarian Cancer and Colon Cancer. Myricetin supplement impacts pathways/processes like Nucleotide metabolism and Estrogen Signaling and creates a supportive effect in those with MLH1 mutation and related conditions.

For Which Cancer Types to Avoid Myricetin Supplement

* Other Factors are also included like BMI, Treatments, Lifestyle Habits

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Myricetin, is an effective tool which can be controlled by you, while facing cancer.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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