Nutritional supplements like Cnidium Monnieri have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Cnidium Monnieri supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Cnidium Monnieri supplements can benefit cancer patients with Renal Non-Clear Cell Carcinoma on Bevacizumab treatment. But avoid Cnidium Monnieri supplements if on Ifosfamide treatment for Testicular Germ Cell Tumors. Similarly, taking nutritional supplement Cnidium Monnieri can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene PTEN. But avoid taking nutritional supplement Cnidium Monnieri when at genetic risk of cancer due to mutation of gene TERT.
The takeaway being – your individual context will influence your decision if nutritional supplement Cnidium Monnieri is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Cnidium Monnieri based on individual context and conditions.
So the question is should you take supplement Cnidium Monnieri? Should you take it when at genetic risk of cancer for mutation of gene TERT? Should you take it when at genetic risk of cancer for mutation of gene PTEN? Should you take it when diagnosed with Testicular Germ Cell Tumors? Should you take Cnidium Monnieri supplement when diagnosed with Renal Non-Clear Cell Carcinoma? Should you take it when on Ifosfamide treatment? Should you continue taking it if you change your treatment from Ifosfamide to Bevacizumab? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Cnidium Monnieri.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Testicular Germ Cell Tumors or Renal Non-Clear Cell Carcinoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Cnidium Monnieri.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Cnidium Monnieri? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene TERT the same as due to mutation of gene PTEN? Are the implications of Testicular Germ Cell Tumors same as Renal Non-Clear Cell Carcinoma? Is it one and the same if you are on treatment with Ifosfamide or on Bevacizumab?
Cnidium Monnieri – A Nutritional Supplement
Cnidium Monnieri is an annual plant which is widely used in traditional herbal medicine. It is used in China, Japan and Vietnam. It contains active ingredients which have a wide variety of pharmacological usage. Some of the reported benefits of Cnidium Monnieri are: (Yi-Min Li et al, Am J Chin Med., 2015)
- May help in the treatment of male impotence
- Possesses anti-allergic effect
- Possesses anti-dermatophytic effect
- Possesses antibacterial and antifungal properties
- Has anti-osteoporotic effects
- Has anticancer properties (Eun Gyeong Lim et al, Mol Med Rep., 2018)
Cnidium Monnieri supplements contain many active ingredients including Osthole and Imperatorin at different concentration levels.(Su-Jane Wang et al, Neurochem Int. 2008) The molecular pathways which are regulated by Cnidium Monnieri include Oxidative Stress, Epithelial to Mesenchymal Transition, MYC Signaling, P53 Signaling and DNA Repair. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Cnidium Monnieri individually or in combination is an important decision to be made. When making decisions on the use of supplement Cnidium Monnieri for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Cnidium Monnieri use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Cnidium Monnieri Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Cnidium Monnieri for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Cnidium Monnieri may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Cnidium Monnieri should be avoided or not and why.
1. Will Cnidium Monnieri Supplements benefit Cancer Patients with Testicular Germ Cell Tumors undergoing Ifosfamide treatment?
Testicular Germ Cell Tumors is characterized and driven by specific genetic mutations like KIT and KRAS leading to biochemical pathway changes in Oxidative Stress, DNA Repair, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and MAPK Signaling. A cancer treatment like Ifosfamide works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Cnidium Monnieri should be avoided for Testicular Germ Cell Tumors along with Ifosfamide treatment. Cnidium Monnieri supplement impacts pathways/processes like Oxidative Stress and DNA Repair which either promote drivers of the Testicular Germ Cell Tumors and/or nullify the treatment effect. Additionally, Cnidium Monnieri supplements contain active ingredients like Imperatorin which has CYP3A4 interaction with the Ifosfamide treatment, and hence should be avoided. (Pius S. Fasinu et al, Front Oncol., 2019; Food and Drug Administration, Meijing Liu et al, Br J Pharmacol., 2018) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Cnidium Monnieri Supplements benefit Cancer Patients with Renal Non-Clear Cell Carcinoma undergoing Bevacizumab Treatment?
Renal Non-Clear Cell Carcinoma is characterized and driven by specific genetic mutations like MUC16 and TP53 leading to biochemical pathway changes in Epithelial to Mesenchymal Transition, MAPK Signaling, Angiogenesis, Small Molecule Transport and PI3K-AKT-MTOR Signaling. A cancer treatment like Bevacizumab works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Cnidium Monnieri supplements should be considered for Renal Non-Clear Cell Carcinoma along with treatment Bevacizumab. Cnidium Monnieri supplements impacts/processes like pathways Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling and MAPK Signaling which either obstruct drivers of the Renal Non-Clear Cell Carcinoma and/or improve the treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Cnidium Monnieri Supplements Safe for Healthy Individuals with TERT Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. TERT is one of the genes generally available in panels for cancer risk testing.
TERT mutation causes biochemical pathways MYC Signaling, MAPK Signaling, Nucleotide metabolism, Stem Cell Signaling and Hypoxia to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Cnidium Monnieri supplement should be avoided when the genetic panel identifies mutation of TERT for Hematological Cancer. Cnidium Monnieri supplement impacts pathways/processes like MYC Signaling and MAPK Signaling and creates adverse effects with TERT and related conditions.
4. Are Cnidium Monnieri Supplements Safe for Healthy Individuals with PTEN Mutation Associated Genetic Risk?
PTEN is one of the genes available in panels for cancer risk testing. PTEN mutation causes biochemical pathways PI3K-AKT-MTOR Signaling, P53 Signaling, Autophagy, Insulin Signaling, Stem Cell Signaling and Endoplasmic Reticulum Stress to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Cnidium Monnieri supplement when the genetic panel identifies mutations in PTEN for Breast Cancer and Kidney Cancer. Cnidium Monnieri supplement impacts pathways/processes like PI3K-AKT-MTOR Signaling, P53 Signaling and Autophagy and creates a supportive effect in those with PTEN mutation and related conditions.
* Other Factors are also included like BMI, Treatments, Lifestyle Habits
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Cnidium Monnieri, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.