Nutritional supplements like Amentoflavone have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Amentoflavone supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Amentoflavone supplements can benefit cancer patients with Small intestine adenocarcinoma on Temozolomide treatment. But avoid Amentoflavone supplements if on Venetoclax treatment for Non-Hodgkin Lymphoma. Similarly, taking nutritional supplement Amentoflavone can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene TP53. But avoid taking nutritional supplement Amentoflavone when at genetic risk of cancer due to mutation of gene TERT.
The takeaway being – your individual context will influence your decision if nutritional supplement Amentoflavone is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. Difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Amentoflavone based on individual context and conditions.
So the question is should you take supplement Amentoflavone? Should you take it when at genetic risk of cancer for mutation of gene TERT? Should you take it when at genetic risk of cancer for mutation of gene TP53? Should you take it when diagnosed with Non-Hodgkin Lymphoma? Should you take Amentoflavone supplement when diagnosed with Small intestine adenocarcinoma? Should you take it when on Venetoclax treatment? Should you continue taking it if you change your treatment from Venetoclax to Temozolomide? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Amentoflavone.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Non-Hodgkin Lymphoma or Small intestine adenocarcinoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Amentoflavone.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Amentoflavone? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene TERT the same as due to mutation of gene TP53? Are the implications of Non-Hodgkin Lymphoma same as Small intestine adenocarcinoma? Is it one and the same if you are on treatment with Venetoclax or on Temozolomide?
Amentoflavone – A Nutritional Supplement
Amentoflavone is a bioflavonoid found in a variety of herbal plants. There are immense health benefits of consuming it and is mainly used for athletic performance. The reported benefits are :
- Has Anti-Inflammation and Anti-Oxidation properties. (Zhen Zhang et al, Neural Regen Res., 2015)
- Controls diabetes ( S Laishram et al, Phytomedicine., 2015)
- Has Antiviral effect (Steffi Wilsky et al, Arch Virol., 2012)
- Possesses anticancer effect ( K S Siveen et al, J Environ Pathol Toxicol Oncol., 2011)
- Has protective effect against neurons (Zhen Zhang et al, Neural Regen Res., 2015)
Amentoflavone is an active ingredient found in various food items. Ginkgo Biloba contains Amentoflavone at different concentration levels along with other active ingredients. The molecular pathways which are regulated by Amentoflavone include Apoptosis, Epithelial to Mesenchymal Transition, MYC Signaling, P53 Signaling and Adherens junction. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Amentoflavone individually or in combination is an important decision to be made. When making decisions on the use of supplement Amentoflavone for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Amentoflavone use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Amentoflavone Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Amentoflavone for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Amentoflavone may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Amentoflavone should be avoided or not and why.
1. Will Amentoflavone Supplements benefit Cancer Patients with Non-Hodgkin Lymphoma undergoing Venetoclax treatment?
Non-Hodgkin Lymphoma is characterized and driven by specific genetic mutations like KMT2D and CREBBP leading to biochemical pathway changes in Apoptosis, P53 Signaling, Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Cancer Epigenetics. A cancer treatment like Venetoclax works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Amentoflavone supplement should be avoided for Non-Hodgkin Lymphoma along with treatment Venetoclax. Amentoflavone supplement impacts pathways/processes like P53 Signaling which either promote drivers of the Non-Hodgkin Lymphoma and/or nullify the treatment effect. Additionally, Amentoflavone supplements have CYP3A4 interactions with Venetoclax treatment, and hence should be avoided by cancer patients. (Food and Drug Administration, Yuka Kimura et al, Food Chem Toxicol., 2010) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Amentoflavone Supplements benefit Cancer Patients with Small intestine adenocarcinoma undergoing Temozolomide Treatment?
Small intestine adenocarcinoma is characterized and driven by specific genetic mutations like TP53 and KRAS leading to biochemical pathway changes in Epithelial to Mesenchymal Transition, Adherens junction, P53 Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. A cancer treatment like Temozolomide works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Amentoflavone supplement should be considered for Small intestine adenocarcinoma along with treatment Temozolomide. Amentoflavone supplement impacts pathways/processes like Epithelial to Mesenchymal Transition, P53 Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling which either obstruct drivers of the Small intestine adenocarcinoma and/or improve the treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Amentoflavone Supplements Safe for Healthy Individuals with TERT Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. TERT is one of the genes generally available in panels for cancer risk testing.
TERT mutation causes biochemical pathways MYC Signaling, MAPK Signaling, Nucleotide metabolism, Stem Cell Signaling and Hypoxia to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Amentoflavone should be avoided when the genetic panel identifies mutation of TERT for Hematological Cancer. Amentoflavone supplement impacts pathways/processes like MYC Signaling and MAPK Signaling and creates adverse effects with TERT and related conditions.
4. Are Amentoflavone Supplements Safe for Healthy Individuals with TP53 Mutation Associated Genetic Risk?
TP53 is one of the genes available in panels for cancer risk testing. TP53 mutation causes biochemical pathways P53 Signaling, MAPK Signaling, Stem Cell Signaling, Estrogen Signaling and Autophagy to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Amentoflavone supplement when the genetic panel identifies mutation in TP53 for Breast Cancer and Lung Cancer. Amentoflavone supplement impacts pathways P53 Signaling and MAPK Signaling and creates a supportive effect in those with TP53 mutation and related conditions.
* Other Factors are also included like BMI, Treatments, Lifestyle Habits
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Amentoflavone, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.