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Ellagic Acid Supplements Improve Radiotherapy Response in Breast Cancer

Jun 16, 2021

Estimated reading time: 5 minutes
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Radiation therapy is commonly used to treat breast cancer, but many times cancer cells can become resistant to radiation therapy. The intake/use of Ellagic Acid from foods such as berries, pomegranate and walnuts (rich in this phenolic compound) or supplements has many potential health benefits including anti-cancer effects. Ellagic acid also improves radiotherapy response in breast cancer cells at the same time being radio-protective to normal cells : a potential natural remedy for breast cancer.

What is Ellagic Acid?

Ellagic Acid is a naturally occurring substance called polyphenol with strong antioxidant properties, found in numerous fruits and vegetables. It is also commercially available in the form of dietary supplements. Ellagic acid has anti-inflammatory and anti-proliferative effects and has many health benefits.

Foods Rich in Ellagic Acid : Ellagic acid is commonly found in various foods including fruits such as raspberries, strawberries, blackberries, cranberries, and pomegranates. Other foods including certain tree nuts such as walnuts and pecans are also rich in Ellagic acid.

Ellagic Acid & Radiotherapy in Breast Cancer

Health Benefits of Ellagic Acid

Some of the potential health benefits of Ellagic acid supplements include anti-cancer effects, reducing the symptoms of chronic metabolic diseases including dyslipidemia, obesity (by the use of ellagic acid from pomegranate extract) and obesity related metabolic complications such as insulin resistance, type 2 diabetes, and nonalcoholic fatty liver disease. (Inhae Kang et al, Adv Nutr., 2016) Additional health benefits of consuming Ellagic Acid also includes interrupting skin wrinkle and inflammation associated with chronic UV exposure. (Ji-Young Bae et al, Exp Dermatol., 2010)

Radiotherapy for Breast Cancer

Breast cancer is the most common type of cancer in women globally ( As of January 2019, there are more than 3.1 million women with a history of breast cancer in the US alone, that includes women who are either ongoing or completed treatment. (U.S. Breast Cancer Statistics; Radiation therapy or Radiotherapy is one of the modalities of cancer treatment besides surgery and chemotherapy and is used routinely to treat the early stages of breast cancer as a localized therapy after surgery, to help lower the chance that the cancer will come back. Radiation therapy is also used when the cancer has relapsed and spread to other organs such as the brain and bones, in combination with other therapies such as chemotherapy or immunotherapy.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Ellagic Acid and Radiotherapy in Breast Cancer

Radiation therapy works by causing damage to the DNA of cancer cells through high energy ionizing particles. However, it also causes collateral damage to the surrounding normal, non-cancer cells, causing some unwanted and severe side-effects. Additionally, with the rapidly evolving nature of cancer cells, they are constantly rewiring their internal machinery and manage to survive the radiotherapy and become radiation resistant. To improve the odds of success of radiation therapy there has been much research on radiosensitizer compounds that when combined with radiation therapy can help achieve greater tumor damage while at the same time being radioprotective of the non-cancer cells. One such natural compound that has experimentally demonstrated this dual property of being a radiosensitizer to breast cancer cells and radioprotective to normal cells is the phenolic compound called Ellagic Acid.

Palliative Care Nutrition for Cancer | When Conventional Treatment is not Working

Studies in breast cancer cells MCF-7 have shown that Ellagic Acid in combination with radiation increases cancer cell death by 50-62% while the same combination was protective in normal cells NIH3T3. The mechanism by which Ellagic Acid worked to enhance the radiation efficacy on breast cancer cells was through negatively affecting the mitochondria – the energy factories of the cells; by increasing the pro cell-death; and reducing the pro-survival factors in the cancer cell. Such studies suggest that natural compounds such as Ellagic Acid could be potentially used to “improve cancer radiotherapy by increasing tumor toxicity and reducing normal cell damage caused by irradiation.” (Ahire V. et al, Nutrition and Cancer, 2017)


In addition to the radiosensitization impact on cancer cells, a large number of scientific studies have also highlighted the many more anti-cancer properties of Ellagic Acid (commonly found in pomegranates), from being able to stop the proliferation of cancer cells, to help induce cancer cell death called apoptosis, prevention of the spread of cancer by blocking the growth of new blood vessels and the migration and invasion of the cancer cells to other parts of the body (Ceci C et al, Nutrients, 2018; Zhang H et al, Cancer Biol Med., 2014). There are clinical trials ongoing in different cancer indications (breast cancer (NCT03482401), colorectal cancer (NCT01916239), prostate cancer (NCT03535675) and others) to validate the chemopreventive and therapeutic benefits of Ellagic Acid in cancer patients, as seen in experimental models of cancer. Despite this natural supplement being non-toxic and safe, Ellagic acid should only be used in consultation with health care specialists, since it has the potential to interact with some drugs due to inhibition of drug metabolizing enzymes in the liver. Also, selecting the right Ellagic acid supplement dose and formulation that has an improved solubility and bioavailability is required to obtain its full therapeutic impact.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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