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What should I Eat?

is the most common question asked by cancer patients.
Choose food and nutritional supplements which avoids bad interactions with your cancer treatment and is good for you.

is the most common question asked by cancer patients. Choose food and nutritional supplements which avoids bad interactions with your cancer treatment and is good for you.

Start Personalized Nutrition Planning for  and answer these questions.

Start Personalized Nutrition Planning for and answer these questions.

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For Which Cancer Types Should I Avoid Uva Ursi Supplement?

Jun 11, 2021

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Highlights

Nutritional supplements like Uva Ursi have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Uva Ursi supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”. 

Taking nutritional Uva Ursi supplements can benefit Diffuse Large B-Cell Lymphoma (DLBCL-Relapsed Refractory) patients on Prednisone cancer treatment. But avoid Uva Ursi supplements if on Carmustine treatment for Pineoblastoma. Similarly, taking nutritional supplement Uva Ursi can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene TP53. But avoid taking nutritional supplement Uva Ursi when at genetic risk of cancer due to mutation of gene TERT.

The takeaway being – your individual context will influence your decision if nutritional supplement Uva Ursi is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context. 



Brief Overview

Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements  are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose  the right combination of supplements like Uva Ursi based on individual context and conditions. 

Uva Ursi Supplements for Cancer Treatment and Genetic Risk

So the question is should you take the supplement Uva Ursi? Should you take it when at genetic risk of cancer for mutation of gene TERT? Should you take it when at genetic risk of cancer for mutation of gene TP53? Should you take it when diagnosed with Pineoblastoma? Should you take Uva Ursi supplement when diagnosed with Diffuse Large B-Cell Lymphoma (DLBCL- Relapsed Refractory)? Should you take it when on Carmustine treatment? Should you continue taking it if you change your treatment from Carmustine to Prednisone? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Uva Ursi. 

Cancer

Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Pineoblastoma or Diffuse Large B-Cell Lymphoma (DLBCL- Relapsed Refractory), the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Uva Ursi.

So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Uva Ursi? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene TERT the same as due to mutation of gene TP53? Are the implications of Pineoblastoma same as Diffuse Large B-Cell Lymphoma (DLBCL-Relapsed Refractory)? Is it one and the same if you are on treatment with Carmustine or on Prednisone? 

Uva Ursi – A Nutritional Supplement

Arctostaphylos Uva Ursi or Uva Ursi commonly known as bearberry, is an evergreen shrub commonly found in the Northern latitudes and high mountains of Europe, Asia and America. The active ingredients in the leaves of Uva Ursi are considered to have strong anti-inflammatory and anti-bacterial effects. The herbal extract of Uva Ursi has been widely used in the Native American traditional medicine  as an alternative treatment or natural remedy for treating urinary tract infections and also as a diuretic. (Susana Garcia de Arriba et al, Int J Toxicol., Nov-Dec 2013) However, there isn’t enough evidence on its effects on kidney stones and bladder damage. Due to its antibacterial properties, it has also been used as an antiseptic.

Uva Ursi supplements contain many active ingredients including Arbutin at different concentration levels. The molecular pathways which are regulated by Uva Ursi include DNA Repair, Cell Cycle, MYC Signaling, P53 Signaling and MAPK Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Uva Ursi individually or in combination is an important decision to be made. When making decisions on the use of supplement Uva Ursi for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Uva Ursi use cannot be a one-size-fits-all decision for all types of cancers.

Choosing Uva Ursi Supplements for Your Cancer

The reason there is no easy way to answer the question “When should I avoid Uva Ursi for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Uva Ursi may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Uva Ursi should be avoided or not and why.

1. Will Uva Ursi Supplements benefit Cancer Patients with Pineoblastoma undergoing Carmustine treatment?

Pineoblastoma is characterized and driven by specific genetic mutations like ATR and ATM leading to biochemical pathway changes in DNA Repair, EPHRIN Signaling and PI3K-AKT-MTOR Signaling. A cancer treatment like Carmustine works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Uva Ursi should be avoided for Pineoblastoma along with treatment Carmustine. Uva Ursi impacts pathways/processes like DNA Repair which either promote drivers of the disease and/or nullify the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).

2. Will Uva Ursi Supplements benefit Cancer Patients with Diffuse Large B-Cell Lymphoma (DLBCL-Relapsed Refractory) undergoing Prednisone Treatment?

Diffuse Large B-Cell Lymphoma (DLBCL-Relapsed Refractory) is characterized and driven by specific genetic mutations like CREBBP and KMT2D leading to biochemical pathway changes in Cell Cycle, MYC Signaling, Apoptosis, PI3K-AKT-MTOR Signaling and P53 Signaling. A cancer treatment like Prednisone works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Uva Ursi supplement should be considered for Diffuse Large B-Cell Lymphoma (DLBCL-Relapsed Refractory) along with treatment Prednisone. Uva Ursi supplement impacts pathways/processes like Cell Cycle and MYC Signaling which either obstruct drivers of the DLBCL disease and/or improve the treatment effect. 

What is Personalized Nutrition for Cancer? | What foods/supplements are recommended?

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.

3. Are Uva Ursi Supplements Safe for Healthy Individuals with TERT Mutation Associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. TERT is one of the genes generally available in panels for cancer risk testing.

TERT mutation causes biochemical pathways MYC Signaling, MAPK Signaling, Nucleotide metabolism, Stem Cell Signaling and Hypoxia to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Uva Ursi should be avoided when the genetic panel identifies a mutation of TERT for Hematological Cancer. Uva Ursi impacts pathways/processes like MYC Signaling and MAPK Signaling and creates adverse effects with TERT and related conditions.

4. Are Uva Ursi Supplements Safe for Healthy Individuals with TP53 Mutation Associated Genetic Risk?

TP53 is one of the genes available in panels for cancer risk testing. TP53 mutation causes biochemical pathways P53 Signaling, MAPK Signaling, Stem Cell Signaling, Estrogen Signaling and Autophagy to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Uva Ursi supplements when the genetic panel identifies mutation in TP53 for Breast Cancer and Lung Cancer. Uva Ursi impacts pathways/processes like P53 Signaling and MAPK Signaling and creates a supportive effect in those with TP53 and related conditions. 

Which Cancer Types to Avoid Uva Ursi Supplement

* Other Factors are also included like BMI, Treatments, Lifestyle Habits

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition, which includes food and nutritional supplements like Uva Ursi, is an effective tool which can be controlled by you, while facing cancer.

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

Get started NOW with answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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