Nutritional supplements like Bloodroot have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Bloodroot supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Bloodroot supplements can benefit Primary Central Nervous System Lymphoma patients on Fluorouracil cancer treatment. But avoid Bloodroot supplements if on Ifosfamide treatment for Metastatic Squamous Neck Cancer with Occult Primary. Similarly, taking nutritional supplement Bloodroot can benefit healthy individuals who are at genetic risk of cancer due to mutation of the gene PDGFRA. But avoid taking nutritional supplement Bloodroot when at genetic risk of cancer due to mutation of gene NBN.
The takeaway being – your individual context will influence your decision if nutritional supplement Bloodroot is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Bloodroot based on individual context and conditions.
So the question is should you take the supplement Bloodroot? Should you take it when at genetic risk of cancer for mutation of gene NBN? Should you take it when at genetic risk of cancer for mutation of the gene PDGFRA? Should you take it when diagnosed with Metastatic Squamous Neck Cancer with Occult Primary? Should you take it when diagnosed with Primary Central Nervous System Lymphoma? Should you take it when on Ifosfamide treatment? Should you continue taking Bloodroot supplement if you change your treatment from Ifosfamide to Fluorouracil? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Bloodroot.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Metastatic Squamous Neck Cancer with Occult Primary or Primary Central Nervous System Lymphoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Bloodroot.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Bloodroot? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene NBN the same as due to mutation of gene PDGFRA? Are the implications of Metastatic Squamous Neck Cancer with Occult Primary same as Primary Central Nervous System Lymphoma? Is it one and the same if you are on treatment with Ifosfamide or on Fluorouracil?
Bloodroot – A Nutritional Supplement
Bloodroot or Sanguinaria canadensis is a herbaceous, perennial, flowering plant native to eastern part of North America.Because of the red latex/fluid of the rhizome of this plant, it is known as bloodroot. Bloodroot is considered to have medicinal properties due to its antioxidant, anti-inflammatory and anti-microbial effects. Native Americans have been using bloodroot as part of traditional medicine to treat a variety of health conditions including (Michael Z Wang et al, Dermatitis., Nov-Dec 2012) :
- Blood purification
- Pain and fever relief
- Wound healing
However, long term use of bloodroot may be unsafe. Hence, before taking these supplements, one should consult with healthcare professional.
Bloodroot supplements contain many active ingredients including Sanguinarine at different concentration levels. The molecular pathways which are regulated by Bloodroot include Cell Cycle, NFKB Signaling, Cell Cycle Checkpoints, RAS-RAF Signaling and Oxidative Stress. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Bloodroot individually or in combination is an important decision to be made. When making decisions on the use of supplement Bloodroot for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Bloodroot use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Bloodroot Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Bloodroot for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Bloodroot may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Bloodroot should be avoided or not and why.
1. Will Bloodroot Supplements benefit Cancer Patients with Metastatic Squamous Neck Cancer with Occult Primary undergoing Ifosfamide treatment?
Metastatic Squamous Neck Cancer with Occult Primary is characterized and driven by specific genetic mutations like TP53 and COL1A1 leading to biochemical pathway changes in Cell Cycle, Oxidative Stress, PI3K-AKT-MTOR Signaling, P53 Signaling and MAPK Signaling. A cancer treatment like Ifosfamide works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Bloodroot should be avoided for Metastatic Squamous Neck Cancer with Occult Primary along with the treatment Ifosfamide. Bloodroot impacts pathways/processes like Cell Cycle and Oxidative Stress which either promote drivers of the disease and/or nullify the treatment effect. Bloodroot supplements contain key active ingredients like Sanguinarine which have CYP2C19 and CYP3A4 (drug metabolizing enzyme) interactions with the treatment, and hence should be avoided by cancer patients undergoing this treatment. (Xiao-Yi Qi et al, Food Chem Toxicol., 2013; Pius S Fasinu et al, Front Oncol., 2019) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Bloodroot Supplements benefit Cancer Patients with Primary Central Nervous System Lymphoma undergoing Fluorouracil Treatment?
Primary Central Nervous System Lymphoma is characterized and driven by specific genetic mutations like MYD88 and CD79B leading to biochemical pathway changes in NFKB Signaling, B Cell Receptor Signaling and RAS-RAF Signaling. A cancer treatment like Fluorouracil works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Bloodroot supplement should be considered for Primary Central Nervous System Lymphoma along with treatment Fluorouracil. Bloodroot supplement impacts pathways/processes like NFKB Signaling which either obstruct drivers of the disease and/or improve the Fluorouracil treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Bloodroot Supplements Safe for Healthy Individuals with NBN Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. NBN is one of the genes generally available in panels for cancer risk testing.
NBN mutation causes biochemical pathways/processes like Cell Cycle Checkpoints, Estrogen Signaling, Stem Cell Signaling, DNA Repair and Angiogenesis to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Bloodroot should be avoided when the genetic panel identifies mutation of NBN for Breast Cancer. Bloodroot impacts pathways/processes like Cell Cycle Checkpoints and Estrogen Signaling and creates adverse effects with NBN and related conditions.
4. Are Bloodroot Supplements Safe for Healthy Individuals with PDGFRA Mutation Associated Genetic Risk?
PDGFRA is one of the genes available in panels for cancer risk testing. PDGFRA mutation causes biochemical pathways/processes like RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, Stem Cell Signaling, Angiogenesis and Growth Factor Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Bloodroot supplements when the genetic panel identifies mutation in PDGFRA for Gastric Cancer. Bloodroot impacts pathways/processes like RAS-RAF Signaling and PI3K-AKT-MTOR Signaling and creates a supportive effect in those with PDGFRA and related conditions.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Bloodroot, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.