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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

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For Which Cancer Types Should I Avoid Walnut Supplement?

Jun 2, 2021

Estimated reading time: 9 minutes
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Highlights

Nutritional supplements like Walnut have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Walnut supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”. 

Taking nutritional Walnut supplements can benefit Juvenile Myelomonocytic Leukemia patients on Trametinib cancer treatment. But avoid Walnut supplements if on Venetoclax treatment for Non-Hodgkin Lymphoma. Similarly, taking nutritional supplement Walnut can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene KIT. But avoid taking nutritional supplement Walnut when at genetic risk of cancer due to mutation of gene BLM.

The takeaway being – your individual context will influence your decision if nutritional supplement Walnut is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context. 



Brief Overview

Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements  are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose  the right combination of supplements like Walnut based on individual context and conditions. 

Walnut Supplements for Cancer Treatment and Genetic Risk

So the question is should you take the supplement Walnut? Should you take it when at genetic risk of cancer for mutation of gene BLM? Should you take it when at genetic risk of cancer for mutation of gene KIT? Should you take it when diagnosed with Non-Hodgkin Lymphoma? Should you take it when diagnosed with Juvenile Myelomonocytic Leukemia? Should you take it when on Venetoclax treatment? Should you continue taking Walnut supplement if you change your treatment from Venetoclax to Trametinib? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Walnut. 

Cancer

Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Non-Hodgkin Lymphoma or Juvenile Myelomonocytic Leukemia, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Walnut.

So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Walnut? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene BLM the same as due to mutation of gene KIT? Are the implications of Non-Hodgkin Lymphoma same as Juvenile Myelomonocytic Leukemia? Is it one and the same if you are on treatment Venetoclax or on Trametinib? 

Walnut – A Nutritional Supplement

Walnut is a tree nut with several active compounds that have antioxidant and anti-inflammatory effects. It is often consumed as a favorite food as part of the weight loss diet as it is energy rich but does not cause a net gain in body weight. Apart from weight loss support, following are some of the other potential health benefits of walnuts:

  • May help reduce blood pressure
  • May help reduce inflammation
  • May support healthy aging
  • May help control blood sugar
  • May promote brain function

Walnut supplements contain many active ingredients including Ellagic Acid, Thymol, Carvacrol, Quercetin, Stigmasterol and Linoleic Acid at different concentration levels. The molecular pathways which are regulated by Walnut include P53 Signaling, RAS-RAF Signaling, Stem Cell Signaling, Nucleotide metabolism and MAPK Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Walnut individually or in combination is an important decision to be made. When making decisions on the use of supplement Walnut for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Walnut use cannot be a one-size-fits-all decision for all types of cancers.

Choosing Walnut Supplements for Your Cancer

The reason there is no easy way to answer the question “When should I avoid Walnut for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Walnut may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Walnut should be avoided or not and why.

1. Will Walnut Supplements benefit Cancer Patients with Non-Hodgkin Lymphoma undergoing Venetoclax treatment?

Non-Hodgkin Lymphoma is characterized and driven by specific genetic mutations like KMT2D and CREBBP leading to biochemical pathway changes in P53 Signaling, MAPK Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling and Cancer Epigenetics. A cancer treatment like Venetoclax works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Walnut should be avoided for Non-Hodgkin Lymphoma along with treatment Venetoclax. Walnut impacts pathways/processes like P53 Signaling and MAPK Signaling which either promote drivers of the disease and/or nullify the treatment effect. Additionally, walnut supplements contain many active ingredients like Ellagic Acid, Quercetin, Stigmasterol and Linoleic Acid which have CYP3A4 interactions with Venetoclax treatment and hence should be avoided by cancer patients undergoing this treatment. (Suresh K. Agarwal, Br J Clin Pharmacol. 2017Hsien-Tsung Yao et al, Life Sci., 2006Fang-fang Zhang et al, Zhejiang Da Xue Xue Bao Yi Xue Ban., 2006; Thangavel Mahalingam Vijayakumar et al, J Food Sci Technol., 2015;  Muneaki Hidaka et al, Drug Metab Dispos., 2005) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).

2. Will Walnut Supplements benefit Cancer Patients with Juvenile Myelomonocytic Leukemia Patients undergoing Trametinib Treatment?

Juvenile Myelomonocytic Leukemia is characterized and driven by specific genetic mutations like PTPN11 and NRAS leading to biochemical pathway changes in RAS-RAF Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling. A cancer treatment like Trametinib works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Walnut supplement should be considered for Juvenile Myelomonocytic Leukemia along with treatment Trametinib. Walnut supplement impacts pathways/processes like RAS-RAF Signaling and MAPK Signaling which either obstruct drivers of the disease and/or improve Trametinib treatment effect. 

For Which Cancer to Avoid taking Supplement Walnut

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Are Walnut Supplements Safe for Healthy Individuals with BLM Mutation Associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. BLM is one of the genes generally available in panels for cancer risk testing.

BLM mutation causes biochemical pathways/processes like Stem Cell Signaling, Estrogen Signaling, DNA Repair, Angiogenesis and Post Translational Modification to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Walnut should be avoided when the genetic panel identifies mutation of BLM for Breast Cancer. Walnut impacts pathways/processes like Stem Cell Signaling and Estrogen Signaling and creates adverse effects with BLM and related conditions.

4. Are Walnut Supplements Safe for Healthy Individuals with KIT Mutation Associated Genetic Risk?

KIT is one of the genes available in panels for cancer risk testing. KIT mutation causes biochemical pathways/processes like Nucleotide metabolism, Stem Cell Signaling, Hypoxia, RAS-RAF Signaling and MAPK Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Walnut supplements when the genetic panel identifies mutation in KIT for Gastric Cancer and Hematological Cancer. Walnut impacts pathways/processes like Nucleotide metabolism and Stem Cell Signaling and creates a supportive effect in those with KIT mutation and related conditions.

Which Cancer Types to Avoid Walnut Supplement

* Other Factors are also included like BMI, Lifestyle Habits, Treatments

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Walnut, is an effective tool which can be controlled by you, while facing cancer.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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