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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

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For Which Cancer Types Should I Avoid Sage Supplement?

Jun 2, 2021

Estimated reading time: 8 minutes
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Highlights

Nutritional supplements like Sage have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Sage supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”. 

Taking nutritional Sage supplements can benefit cancer patients with Rosai-Dorfman disease on Cladribine treatment. But avoid Sage supplements if on Venetoclax treatment for Non-Hodgkin Lymphoma. Similarly, taking nutritional supplement Sage can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene CDKN2A. But avoid taking nutritional supplement Sage when at genetic risk of cancer due to mutation of gene RAD50.

The takeaway being – your individual context will influence your decision if nutritional supplement Sage is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.



Brief Overview

Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements  are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose  the right combination of supplements like Sage based on individual context and conditions.

Sage Supplements for Cancer Treatment and Genetic Risk

So the question is should you take supplement Sage? Should you take it when at genetic risk of cancer for mutation of gene RAD50? Should you take it when at genetic risk of cancer for mutation of gene CDKN2A? Should you take it when diagnosed with Non-Hodgkin Lymphoma? Should you take Sage supplement when diagnosed with Rosai-Dorfman disease? Should you take it when on Venetoclax treatment? Should you continue taking it if you change your treatment from Venetoclax to Cladribine? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Sage. 

Cancer

Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Non-Hodgkin Lymphoma or Rosai-Dorfman disease, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Sage.

So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Sage? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene RAD50 the same as due to mutation of gene CDKN2A? Are the implications of Non-Hodgkin Lymphoma same as Rosai-Dorfman disease? Is it one and the same if you are on treatment with Venetoclax or on Cladribine? 

Sage – A Nutritional Supplement

Sage is a perennial herb which belongs to the mint family. It has aromatic flavour and is known for its healing properties. Sage is rich in phenolic compounds which have strong antioxidant properties which reduces free radicals. The benefits of consuming sage are:

Sage supplements contain many active ingredients including Carnosic acid, Caffeic Acid, Oleanolic Acid and Linoleic Acid at different concentration levels. The molecular pathways which are regulated by Sage include P53 Signaling, MYC Signaling, Stem Cell Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Sage individually or in combination is an important decision to be made. When making decisions on the use of supplement Sage for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Sage use cannot be a one-size-fits-all decision for all types of cancers.

Choosing Sage Supplements for Your Cancer

The reason there is no easy way to answer the question “When should I avoid Sage for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Sage may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Sage should be avoided or not and why.

1. Will Sage Supplements benefit Cancer Patients with Non-Hodgkin Lymphoma undergoing Venetoclax treatment?

Non-Hodgkin Lymphoma is characterized and driven by specific genetic mutations like KMT2D and CREBBP leading to biochemical pathway changes in P53 Signaling, PI3K-AKT-MTOR Signaling, Vitamin D Signaling and Cancer Epigenetics. A cancer treatment like Venetoclax works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Sage should be avoided for Non-Hodgkin Lymphoma along with Venetoclax treatment. Sage supplement impacts pathways/processes like Vitamin D Signaling which either promote drivers of the Non-Hodgkin Lymphoma and/or nullify the treatment effect. Additionally, Sage supplements contain active ingredients like Carnosic acid which has CYP3A4 interaction with the Venetoclax treatment, and hence should be avoided. (Suresh K. Agarwal, Br J Clin Pharmacol. 2017 ; Leslie J Dickmann et al, Drug Metab Dispos., 2012) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).

2. Will Sage Supplements benefit Cancer Patients with Rosai-Dorfman disease undergoing Cladribine Treatment?

Rosai-Dorfman disease is characterized and driven by specific genetic mutations like KRAS and MAP2K1 leading to biochemical pathway changes in MYC Signaling, RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. A cancer treatment like Cladribine works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Sage supplement should be considered for Rosai-Dorfman disease along with treatment Cladribine. Sage supplement impacts pathways/processes like MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling which either obstruct drivers of the Rosai-Dorfman disease and/or improve the treatment effect.

For Which Cancer to Avoid taking Supplement Sage

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Are Sage Supplements Safe for Healthy Individuals with RAD50 Mutation Associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. RAD50 is one of the genes generally available in panels for cancer risk testing.

RAD50 mutation causes biochemical pathways Stem Cell Signaling, Estrogen Signaling, DNA Repair, Angiogenesis and Growth Factor Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Sage supplement should be avoided when the genetic panel identifies mutation of RAD50 for Breast Cancer. Sage supplement impacts pathways/processes like  DNA Repair and Estrogen Signaling and creates adverse effects with RAD50 and related conditions.

4. Are Sage Supplements Safe for Healthy Individuals with CDKN2A Mutation Associated Genetic Risk?

CDKN2A is one of the genes available in panels for cancer risk testing. CDKN2A mutation causes biochemical pathways Stem Cell Signaling, P53 Signaling, MAPK Signaling and Cell Cycle to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Sage supplement when the genetic panel identifies mutations in CDKN2A for Skin Cancer and Head And Neck Squamous Cell Carcinoma. Sage supplement impacts pathways/processes like Stem Cell Signaling, MAPK Signaling and Cell Cycle and creates a supportive effect in those with CDKN2A mutation and related conditions.

For Which Cancer Types to Avoid Sage Supplement

* Other Factors are also included like BMI, Lifestyle Habits, Treatments

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Sage, is an effective tool which can be controlled by you, while facing cancer.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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