Nutritional supplements like Pineapple have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Pineapple supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Pineapple supplements can benefit Primary Central Nervous System Lymphoma patients on Epirubicin cancer treatment. But avoid Pineapple supplements if on Vinblastine treatment for Chronic Neutrophilic Leukemia. Similarly, taking the nutritional supplement Pineapple can benefit healthy individuals who are at genetic risk of cancer due to mutation of the gene CDKN1B. But avoid taking nutritional supplement Pineapple when at genetic risk of cancer due to mutation of gene POLH.
The takeaway being – your individual context will influence your decision if the nutritional supplement Pineapple is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Pineapple based on individual context and conditions.
So the question is should you take the supplement Pineapple? Should you take it when at genetic risk of cancer for mutation of gene POLH? Should you take it when at genetic risk of cancer for mutation of gene CDKN1B? Should you take it when diagnosed with Chronic Neutrophilic Leukemia? Should you take it when diagnosed with Primary Central Nervous System Lymphoma? Should you take it when on Vinblastine treatment? Should you continue taking Pineapple supplement if you change your treatment from Vinblastine to Epirubicin? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Pineapple.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Chronic Neutrophilic Leukemia or Primary Central Nervous System Lymphoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Pineapple.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Pineapple? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene POLH the same as due to mutation of gene CDKN1B? Are the implications of Chronic Neutrophilic Leukemia same as Primary Central Nervous System Lymphoma? Is it one and the same if you are on treatment with Vinblastine or on Epirubicin?
Pineapple – A Nutritional Supplement
Pineapple is a tropical, flavorful fruit with a unique aroma and great taste. It contains a group of digestive enzymes called Bromelain and hence may help in digestion. Pineapple is loaded with antioxidants and may boost immunity. Additionally, pineapple intake may also help in improving heart health, and in reducing inflammation. However, pineapple supplements may interact with certain drugs like antibiotics and blood thinners. Some people may also be allergic to pineapple and its intake can lead to rashes and breathing problems.
Pineapple supplements contain many active ingredients including Bromelain, Linoleic Acid, Linolenic Acid, Ergosterol Peroxide and Salicylic Acid at different concentration levels. The molecular pathways which are regulated by Pineapple include Apoptosis, Cell Cycle, Angiogenesis, FOXO Signaling and RAS-RAF Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Pineapple individually or in combination is an important decision to be made. When making decisions on the use of supplement Pineapple for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Pineapple use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Pineapple Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Pineapple for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Pineapple may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Pineapple should be avoided or not and why.
1. Will Pineapple Supplements benefit Cancer Patients with Chronic Neutrophilic Leukemia undergoing Vinblastine treatment?
Chronic Neutrophilic Leukemia is characterized and driven by specific genetic mutations like ASXL1 and TET2 leading to biochemical pathway changes in Apoptosis, RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, Cancer Epigenetics and mRNA Splicing. A cancer treatment like Vinblastine works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Pineapple should be avoided for Chronic Neutrophilic Leukemia along with treatment Vinblastine. Pineapple impacts pathways/processes like Apoptosis and RAS-RAF Signaling which either promote drivers of the disease and/or nullify the treatment effect. Additionally, Pineapple supplements contain active ingredients like Linoleic Acid and Linolenic Acid which have CYP3A4 interactions with Vinblastine treatment, and hence should be avoided by cancer patients undergoing this treatment. (Hsien-Tsung Yao et al, Life Sci., 2006; Nicola F Smith et al, Ann Pharmacother., 2010) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Pineapple Supplements benefit Cancer Patients with Primary Central Nervous System Lymphoma undergoing Epirubicin Treatment?
Primary Central Nervous System Lymphoma is characterized and driven by specific genetic mutations like MYD88 and CD79B leading to biochemical pathway/process changes in Cell Cycle, NFKB Signaling, Apoptosis, B Cell Receptor Signaling and RAS-RAF Signaling. A cancer treatment like Epirubicin works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Pineapple supplement should be considered for Primary Central Nervous System Lymphoma along with treatment Epirubicin. Pineapple supplement impacts pathways/processes like Cell Cycle and NFKB Signaling which either obstruct drivers of the disease and/or improve Epirubicin treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Pineapple Supplements Safe for Healthy Individuals with POLH Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. POLH is one of the genes generally available in panels for cancer risk testing.
POLH mutation causes biochemical pathways/processes like Angiogenesis, MAPK Signaling, Stem Cell Signaling and DNA Repair to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Pineapple should be avoided when the genetic panel identifies a mutation of POLH for Skin Cancer. Pineapple impacts pathways/processes like Angiogenesis and MAPK Signaling and creates adverse effects with POLH and related conditions.
4. Are Pineapple Supplements Safe for Healthy Individuals with CDKN1B Mutation Associated Genetic Risk?
CDKN1B is one of the genes available in panels for cancer risk testing. CDKN1B mutation causes biochemical pathways/processes like FOXO Signaling, Cell Cycle, Stem Cell Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Pineapple supplements when the genetic panel identifies mutation in CDKN1B for Neuroendocrine Cancer. Pineapple impacts pathways/processes like FOXO Signaling and Cell Cycle and creates a supportive effect in those with CDKN1B mutation and related conditions.
* Other Factors are also included like BMI, Lifestyle Habits, Treatments
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Pineapple, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.