Nutritional supplements like Persimmon have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Persimmon supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Persimmon supplements can benefit Early T Cell Precursor Acute Lymphoblastic Leukemia patients on Nelarabine cancer treatment. But avoid Persimmon supplements if on Cytarabine treatment for Myeloproliferative Neoplasms. Similarly, taking nutritional supplement Persimmon can benefit healthy individuals who are at genetic risk of cancer due to mutation of the gene CDKN1B. But avoid taking nutritional supplement Persimmon when at genetic risk of cancer due to mutation of gene BLM.
The takeaway being – your individual context will influence your decision if nutritional supplement Persimmon is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Persimmon based on individual context and conditions.
So the question is should you take the supplement Persimmon? Should you take it when at genetic risk of cancer for mutation of gene BLM? Should you take it when at genetic risk of cancer for mutation of gene CDKN1B? Should you take it when diagnosed with Myeloproliferative Neoplasms? Should you take it when diagnosed with Early T Cell Precursor Acute Lymphoblastic Leukemia? Should you take it when on Cytarabine treatment? Should you continue taking Persimmon supplement if you change your treatment from Cytarabine to Nelarabine? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Persimmon.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Myeloproliferative Neoplasms or Early T Cell Precursor Acute Lymphoblastic Leukemia, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Persimmon.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Persimmon? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene BLM the same as due to mutation of gene CDKN1B? Are the implications of Myeloproliferative Neoplasms same as Early T Cell Precursor Acute Lymphoblastic Leukemia? Is it one and the same if you are on treatment with Cytarabine or on Nelarabine?
Persimmon – A Nutritional Supplement
Persimmon is a delicious, globular, orange colored fruit with strong antioxidant properties, and native to China, Northeast India and Northern Indochina. Persimmon fruits are usually low in calories and high in fiber. Being packed with powerful antioxidants like vitamins, minerals and fiber, persimmon intake may :
- Help in optimizing eye health
- Help in boosting immunity
- Help in reducing the risk of diseases like stroke and cardiovascular diseases
- help in reducing inflammation
- Help in managing diabetes
Persimmon supplements contain many active ingredients including Fisetin, Folic Acid, Lycopene and Quercetin at different concentration levels. The molecular pathways which are regulated by Persimmon include MYC Signaling, PI3K-AKT-MTOR Signaling, Stem Cell Signaling, MAPK Signaling and Estrogen Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Persimmon individually or in combination is an important decision to be made. When making decisions on the use of supplement Persimmon for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Persimmon use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Persimmon Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Persimmon for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Persimmon may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Persimmon should be avoided or not and why.
1. Will Persimmon Supplements benefit Cancer Patients with Myeloproliferative Neoplasms undergoing Cytarabine treatment?
Myeloproliferative Neoplasms is characterized and driven by specific genetic mutations like JAK2 and CALR leading to biochemical pathway changes in MYC Signaling, MAPK Signaling, JAK-STAT Signaling, Cytokine Signaling and Hematopoiesis. A cancer treatment like Cytarabine works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Persimmon should be avoided for Myeloproliferative Neoplasms along with treatment Cytarabine. Persimmon impacts pathways/processes like MYC Signaling and MAPK Signaling which either promote drivers of the disease and/or nullify the treatment effect. Additionally, Persimmon supplements contain key active ingredients like Fisetin and Quercetin which have CYP3A4 interactions with Cytarabine treatment and hence should be avoided by cancer patients undergoing this treatment. (Mаhmoud Youns and Wael Abdel Halim Hegazy et al, PLoS One., 2017; Fang-fang Zhang et al, Zhejiang Da Xue Xue Bao Yi Xue Ban., 2006; Dawn E Colburn et al, Hematology., 2004) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Persimmon Supplements benefit Cancer Patients with Early T Cell Precursor Acute Lymphoblastic Leukemia undergoing Nelarabine Treatment?
Early T Cell Precursor Acute Lymphoblastic Leukemia is characterized and driven by specific genetic mutations like CDKN2A and JAK3 leading to biochemical pathway changes in PI3K-AKT-MTOR Signaling, MAPK Signaling, JAK-STAT Signaling, Cell Cycle and RAS-RAF Signaling. A cancer treatment like Nelarabine works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Persimmon supplement should be considered for Early T Cell Precursor Acute Lymphoblastic Leukemia along with treatment Nelarabine. Persimmon supplement impacts pathways/processes like PI3K-AKT-MTOR Signaling and MAPK Signaling which either obstruct drivers of the disease and/or improve Nelarabine treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Persimmon Supplements Safe for Healthy Individuals with BLM Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. BLM is one of the genes generally available in panels for cancer risk testing.
BLM mutation causes biochemical pathways Stem Cell Signaling, Estrogen Signaling, DNA Repair, Angiogenesis and Post Translational Modification to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Persimmon should be avoided when the genetic panel identifies mutation of BLM for Breast Cancer. Persimmon impacts pathways/processes like Stem Cell Signaling and Estrogen Signaling and creates adverse effects with BLM and related conditions.
4. Are Persimmon Supplements Safe for Healthy Individuals with CDKN1B Mutation Associated Genetic Risk?
CDKN1B is one of the genes available in panels for cancer risk testing. CDKN1B mutation causes biochemical pathways/processes like Stem Cell Signaling, FOXO Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Persimmon supplements when the genetic panel identifies mutation in CDKN1B for Neuroendocrine Cancer. Persimmon impacts pathways/processes like Stem Cell Signaling and FOXO Signaling and creates a supportive effect in those with CDKN1B mutation and related conditions.
* Other Factors are also included like BMI, Lifestyle Habits, Treatments
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Persimmon, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.