Nutritional supplements like Eggplant have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Eggplant supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Eggplant supplements can benefit cancer patients with Juvenile Myelomonocytic Leukemia on Trametinib treatment. But avoid Eggplant supplements if on Pazopanib treatment for Chronic myeloid leukaemia. Similarly, taking nutritional supplement Eggplant can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene SDHA. But avoid taking nutritional supplement Eggplant when at genetic risk of cancer due to mutation of gene CDC73.
The takeaway being – your individual context will influence your decision if nutritional supplement Eggplant is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Eggplant based on individual context and conditions.
So the question is should you take supplement Eggplant? Should you take it when at genetic risk of cancer for mutation of gene CDC73? Should you take it when at genetic risk of cancer for mutation of gene SDHA? Should you take it when diagnosed with Chronic myeloid leukaemia? Should you take Eggplant supplement when diagnosed with Juvenile Myelomonocytic Leukemia? Should you take it when on Pazopanib treatment? Should you continue taking it if you change your treatment from Pazopanib to Trametinib? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Eggplant.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Chronic myeloid leukaemia or Juvenile Myelomonocytic Leukemia, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Eggplant.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Eggplant? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene CDC73 the same as due to mutation of gene SDHA? Are the implications of Chronic myeloid leukaemia same as Juvenile Myelomonocytic Leukemia? Is it one and the same if you are on treatment with Pazopanib or on Trametinib?
Eggplant – A Nutritional Supplement
Eggplant is often referred to as the king of vegetables. It is also called brinjal which belongs to members of nightshade. It is rich in antioxidants and has multiple health benefits. Some of the purported/potential benefits of consuming eggplants are :
- Maintenance of healthy bones
- Reduce the risk of heart disease
- Help in controlling blood sugar
- Help in treatment of anemia
- Aids in digestion
- Helps in weight loss
- Possesses anticancer properties (Monruedee Sukprasansap et al, Mutat Res. 2019; Bill Elliot Cham et al, Planta Med. 2012)
Over consumption of eggplant may lead to kidney stones.
Eggplant supplements contain many active ingredients including Delphinidin, Linoleic Acid, Salicylic Acid and Solasodine at different concentration levels. The molecular pathways which are regulated by Eggplant include Oxidative Stress, RAS-RAF Signaling, WNT Beta Catenin Signaling, Stem Cell Signaling and TGFB Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Eggplant individually or in combination is an important decision to be made. When making decisions on the use of supplement Eggplant for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Eggplant use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Eggplant Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Eggplant for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Eggplant may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Eggplant should be avoided or not and why.
1. Will Eggplant Supplements benefit Cancer Patients with Chronic myeloid leukaemia undergoing Pazopanib treatment?
Chronic myeloid leukaemia is characterized and driven by specific genetic mutations like BCR-ABL1 and RUNX1 leading to biochemical pathway changes in Oxidative Stress, TGFB Signaling, PI3K-AKT-MTOR Signaling, Growth Factor Signaling and Cancer Epigenetics. A cancer treatment like Pazopanib works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Eggplant supplement should be avoided for Chronic myeloid leukaemia along with Pazopanib treatment. Eggplant supplement impacts pathways/processes like Oxidative Stress and TGFB Signaling which either promote drivers of the disease and/or nullify the treatment effect. Additionally, Eggplant supplements contain active ingredients like Linoleic Acid which has CYP3A4 interactions with Pazopanib treatment, and hence should be avoided. (Pius S. Fasinu et al, Front Oncol., 2019; Camille Azam et al, Eur J Clin Pharmacol., 2020; Hsien-Tsung Yao et al, Life Sci. 2006) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Eggplant Supplements benefit Cancer Patients with Juvenile Myelomonocytic Leukemia undergoing Trametinib Treatment?
Juvenile Myelomonocytic Leukemia is characterized and driven by specific genetic mutations like PTPN11 and NRAS leading to biochemical pathway changes in RAS-RAF Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling. A cancer treatment like Trametinib works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Eggplant supplement should be considered for Juvenile Myelomonocytic Leukemia along with treatment Trametinib. Eggplant supplement impacts pathways/processes like MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling which either obstruct drivers of the Juvenile Myelomonocytic Leukemia and/or improve the treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Eggplant Supplements Safe for Healthy Individuals with CDC73 Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. CDC73 is one of the genes generally available in panels for cancer risk testing.
CDC73 mutation causes biochemical pathways WNT Beta Catenin Signaling, Angiogenesis and Stem Cell Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Eggplant should be avoided when the genetic panel identifies mutation of CDC73 for Neuroendocrine Cancer. Eggplant impacts pathways/processes like WNT Beta Catenin Signaling and Angiogenesis and creates adverse effects with CDC73 and related conditions.
4. Are Eggplant Supplements Safe for Healthy Individuals with SDHA Mutation Associated Genetic Risk?
SDHA is one of the genes available in panels for cancer risk testing. SDHA mutation causes biochemical pathways Stem Cell Signaling, Hypoxia, Carbohydrate Metabolism, MAPK Signaling and Energy Metabolism to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Eggplant supplements when the genetic panel identifies mutations in SDHA for Thyroid Cancer and Neuroendocrine Cancer. Eggplant impacts pathways/processes like Stem Cell Signaling and Hypoxia and create an protective effect in those with SDHA mutations and related conditions.
* Other Factors are also included like BMI, Lifestyle Habits, Treatments
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Eggplant, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.