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What should I Eat?

is the most common question asked by cancer patients.
Choose food and nutritional supplements which avoids bad interactions with your cancer treatment and is good for you.

is the most common question asked by cancer patients. Choose food and nutritional supplements which avoids bad interactions with your cancer treatment and is good for you.

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For Which Cancer Types Should I Avoid Cardamom Supplements?

Jun 1, 2021

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Highlights

Nutritional supplements like Cardamom have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Cardamom supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”. 

Taking nutritional Cardamom supplements can benefit cancer patients with Juvenile Myelomonocytic Leukemia on Trametinib treatment. But avoid Cardamom supplements if on Pazopanib treatment for Chronic myeloid leukaemia. Similarly, taking nutritional supplement Cardamom can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene CDKN2A. But avoid taking nutritional supplement Cardamom when at genetic risk of cancer due to mutation of gene BRIP1.

The takeaway being – your individual context will influence your decision if nutritional supplement Cardamom is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.



Brief Overview

Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements  are high concentrations of active ingredients which are also found in different foods. Difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose  the right combination of supplements like Cardamom based on individual context and conditions.

Cardamom Supplements for Cancer Treatment and Genetic Risk

So the question is should you take supplement Cardamom? Should you take it when at genetic risk of cancer for mutation of gene BRIP1? Should you take it when at genetic risk of cancer for mutation of gene CDKN2A? Should you take it when diagnosed with Chronic myeloid leukaemia? Should you take cardamom supplement when diagnosed with Juvenile Myelomonocytic Leukemia? Should you take it when on Pazopanib treatment? Should you continue taking it if you change your treatment from Pazopanib to Trametinib? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Cardamom. 

Cancer

Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Chronic myeloid leukaemia or Juvenile Myelomonocytic Leukemia, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Cardamom.

So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Cardamom? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene BRIP1 the same as due to mutation of gene CDKN2A? Are the implications of Chronic myeloid leukaemia same as Juvenile Myelomonocytic Leukemia? Is it one and the same if you are on treatment with Pazopanib or on Trametinib? 

Cardamom – A Nutritional Supplement

Cardamom is called the queen of spices and is native of Indian subcontinent. It has aromatic flavour and is used in a variety of cuisines to enhance the flavour. The health benefits of consuming cardamom are :

Cardamom supplements contain many active ingredients including Eucalyptol, Linalool, Linoleic Acid and Myrcene at different concentration levels. The molecular pathways which are regulated by Cardamom include Oxidative Stress, RAS-RAF Signaling, NFKB Signaling, P53 Signaling and TGFB Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Cardamom individually or in combination is an important decision to be made. When making decisions on the use of supplement Cardamom for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Cardamom use cannot be a one-size-fits-all decision for all types of cancers.

Choosing Cardamom Supplements for Your Cancer

The reason there is no easy way to answer the question “When should I avoid Cardamom for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Cardamom may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Cardamom should be avoided or not and why.

1. Will Cardamom Supplements benefit Cancer Patients with Chronic myeloid leukaemia undergoing Pazopanib treatment?

Chronic myeloid leukaemia is characterized and driven by specific genetic mutations like BCR-ABL1 and RUNX1 leading to biochemical pathway changes in Oxidative Stress, TGFB Signaling, PI3K-AKT-MTOR Signaling, Growth Factor Signaling and Cancer Epigenetics. A cancer treatment like Pazopanib works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Cardamom should be avoided for Chronic myeloid leukaemia along with treatment Pazopanib. Cardamom supplement impacts pathways/processes like Oxidative Stress and TGFB Signaling which either promote drivers of the Chronic myeloid leukaemia and/or nullify the treatment effect. Additionally, Cardamom supplements contain active ingredients like Myrcene which has CYP3A4 interaction with the Pazopanib treatment, and hence should be avoided. (Pius S. Fasinu et al, Front Oncol., 2019; Camille Azam, Eur J Clin Pharmacol.,  2020; Oliver Yoa-Pu Hu et al, Patent, 2002) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).

2. Will Cardamom Supplements benefit Cancer Patients with Juvenile Myelomonocytic Leukemia undergoing Trametinib Treatment?

Juvenile Myelomonocytic Leukemia is characterized and driven by specific genetic mutations like PTPN11 and NRAS leading to biochemical pathway changes in RAS-RAF Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling. A cancer treatment like Trametinib works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Cardamom supplement should be considered for Juvenile Myelomonocytic Leukemia along with treatment Trametinib. Cardamom supplement impacts pathways/processes like MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling which either obstruct drivers of the Juvenile Myelomonocytic Leukemia and/or improve the treatment effect.

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3. Are Cardamom Supplements Safe for Healthy Individuals with BRIP1 Mutation Associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. BRIP1 is one of the genes generally available in panels for cancer risk testing.

BRIP1 mutation causes biochemical pathways NFKB Signaling, Estrogen Signaling, Stem Cell Signaling, P53 Signaling and DNA Repair to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Cardamom should be avoided when the genetic panel identifies mutation of BRIP1 for Ovarian Cancer. Cardamom impacts pathways/processes like Estrogen Signaling and creates adverse effects with BRIP1 and related conditions.

4. Are Cardamom Supplements Safe for Healthy Individuals with CDKN2A Mutation Associated Genetic Risk?

CDKN2A is one of the genes available in panels for cancer risk testing. CDKN2A mutation causes biochemical pathways P53 Signaling, MAPK Signaling, Stem Cell Signaling and Cell Cycle to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Cardamom supplements when the genetic panel identifies mutation in CDKN2A for Skin Cancer and Head And Neck Squamous Cell Carcinoma. Cardamom impacts pathways/processes like Cell Cycle, P53 Signaling and MAPK Signaling and creates a supportive effect in those with CDKN2A mutations and related conditions.

For Which Cancer Types to Avoid Cardamom Supplement

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Cardamom, is an effective tool which can be controlled by you, while facing cancer.

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

Get started NOW with answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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