No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Chondrosarcoma (Bone Cancer) needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Alfalfa and Allspice should be eaten when undergoing Pazopanib treatment for Chondrosarcoma. On the same lines, foods like Amaranth and Beetroot should be avoided with treatment of Pazopanib for Chondrosarcoma.
Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Pazopanib treatment and hence should be avoided. Also, an in vitro experimental study found that Curcumin, a key ingredient of Turmeric may have anti-cancer potential in chondrosarcomas. However, Curcumin has CYP (drug metabolizing enzyme) interactions with Pazopanib treatment and hence should be avoided while undergoing this treatment.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Chondrosarcoma.
What is Chondrosarcoma?
Chondrosarcoma – a soft tissue sarcoma, is a rare cancer that develops in the bones, but may also occur in the soft tissue near bones. This cancer mostly affects the pelvis, hip and shoulder regions, however, in some cases the base of the skull is also affected. The incidence rate of this cancer is only 0.05 per 1 lakh people per year. This cancer is commonly diagnosed in people who are over 50 years of age, however, it can occur in people of any age. It is more commonly found in men as compared to women.
Chondrosarcoma has prevalence of certain genetic changes. Some of the genes such as IDH1, COL2A1, TP53, and TTN are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Chondrosarcoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Chondrosarcoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Chondrosarcoma (Bone Cancer) genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Chondrosarcoma nutrition may have to be redesigned.
Why Eating Right Matters for Chondrosarcoma (Bone Cancer)?
In Chondrosarcoma, activation or inhibition of some of the biochemical pathways including Hypoxia, MAPK Signaling, Carbohydrate Metabolism, Cancer Epigenetics, RAS-RAF Signaling, Oxidative Stress, Angiogenesis and PI3K-AKT-MTOR Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Chondrosarcoma (Bone Cancer), eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Pazopanib treatment for Chondrosarcoma (Bone Cancer)
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Chondrosarcoma considering only one specific treatment – Pazopanib.
Foods to Avoid with Pazopanib treatment
Amaranth and Beetroot : Amaranth and Beetroot contains active ingredients such as Citric Acid, Folic Acid, Stigmasterol and others. Citric Acid interferes with the impact of Pazopanib in Chondrosarcoma by blocking a specific biological process called Oxidative Stress. Oxidative stress has been shown to induce apoptosis or cell death in different cancer cells. Hence, do not eat Amaranth and Beetroot with Pazopanib treatment for Chondrosarcoma. (Omar M E Abdel-Salam et al, J Med Food., 2014; Silvia Stacchiotti et al, Lancet Oncol., 2019)
Foods to Eat with Pazopanib treatment
Alfalfa : Alfalfa contains active ingredients like Vitamin C, Genistein, 7-4′-dihydroxyflavone. Intake of Vitamin C along with Pazopanib treatment for Chondrosarcoma causes a decrease in a specific biochemical pathway which is called Hypoxia, and this is a very positive effect. Tumor hypoxia leads to resistance to different anticancer chemotherapies. Alfalfa hence should be eaten with Pazopanib treatment for Chondrosarcoma. (Michela Codini et al, Int. J. Mol. Sci., 2020; Katerina Stamati et al, J Tissue Eng., 2020; J Martin Brown et al, Methods Enzymol., 2007; Silvia Stacchiotti et al, Lancet Oncol., 2019)
Allspice : Allspice contains active ingredients like Vitamin C, Eucalyptol, Gallic Acid. As mentioned above, the intake of Vitamin C along with Pazopanib treatment for Chondrosarcoma causes a decrease in a specific biochemical pathway which is called Hypoxia, and this is a very positive effect.Tumor hypoxia leads to resistance to different anticancer chemotherapies. Allspice hence should be eaten with Pazopanib treatment for Chondrosarcoma. (Michela Codini et al, Int. J. Mol. Sci., 2020; Katerina Stamati et al, J Tissue Eng., 2020; J Martin Brown et al, Methods Enzymol., 2007; Silvia Stacchiotti et al, Lancet Oncol., 2019)
Should I take this Nutritional Supplement with Pazopanib treatment?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Pazopanib treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Pazopanib treatment efficacy in Chondrosarcoma. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Caroline F Thorn et al, Pharmacogenet Genomics., 2017; Silvia Stacchiotti et al, Lancet Oncol., 2019)
Curcumin : In a study done by the researchers from the China Medical University Hospital, Taichung, Taiwan, they found that Curcumin, a key ingredient in Turmeric, could induce apoptosis (cell death) of human chondrosarcoma cell lines. (Hsiang-Ping Lee et al, Int Immunopharmacol., 2012) However, curcumin nutritional supplements have CYP3A4 interactions with Pazopanib treatment, and hence should not be used while on this treatment. (Yow-Wen Hsieh et al, Sci Rep., 2014; Caroline F Thorn et al, Pharmacogenet Genomics., 2017; Silvia Stacchiotti et al, Lancet Oncol., 2019)
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Chondrosarcoma?
Pain is the most common symptom of bone cancers such as chondrosarcoma. As the disease progresses, Chondrosarcoma may start showing more symptoms.
Following are some of the signs and symptoms that may be caused by Chondrosarcoma.
- A large swelling or palpable mass on the affected bone
- Increasing pain
- Bone fractures
- Feeling of pressure around the mass.
- Local swelling
- Increases in pain at night.
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Chondrosarcoma.
What are the Treatment Options for this Cancer?
The treatment for Chondrosarcoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Chondrosarcoma include:
Surgery or surgery followed by radiation is the most common treatment regimen for Chondrosarcoma. Radiotherapy helps to shrink the tumor. The primary role of chemotherapy is in the treatment of metastatic disease. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Chondrosarcoma (Bone Cancer).
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Chondrosarcoma (Bone Cancer).
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.