Nutritional supplements like Arugula have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Arugula supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Arugula supplements can benefit cancer patients with Juvenile Myelomonocytic Leukemia on Trametinib treatment. But avoid Arugula supplements if on Doxorubicin treatment for Desmoid Tumor. Similarly, taking nutritional supplement Arugula can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene CDKN2A. But avoid taking nutritional supplement Arugula when at genetic risk of cancer due to mutation of gene CDH1.
The takeaway being – your individual context will influence your decision if nutritional supplement Arugula is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Arugula based on individual context and conditions.
So the question is should you take supplement Arugula? Should you take it when at genetic risk of cancer for mutation of gene CDH1? Should you take it when at genetic risk of cancer for mutation of gene CDKN2A? Should you take it when diagnosed with Desmoid Tumor? Should you take Arugula supplement when diagnosed with Juvenile Myelomonocytic Leukemia? Should you take it when on Doxorubicin treatment? Should you continue taking it if you change your treatment from Doxorubicin to Trametinib? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Arugula.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Desmoid Tumor or Juvenile Myelomonocytic Leukemia, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Arugula.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Arugula? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene CDH1 the same as due to mutation of gene CDKN2A? Are the implications of Desmoid Tumor same as Juvenile Myelomonocytic Leukemia? Is it one and the same if you are on treatment with Doxorubicin or on Trametinib?
Arugula – A Nutritional Supplement
Arugula is a green leafy cruciferous vegetable which has a peppery taste. It is considered as a salad vegetable which is native of Mediterranean region. Some of the purported uses/potential health benefits of Arugula include:
- Reduces inflammation
- Promotes bone health
- Helps in weight management
- Promotes eye health
- Helps in maintaining blood pressure
Arugula consumption can lead to short-term side effects like abdominal discomfort and cramps.
Arugula supplements contain many active ingredients including Retinol, Kaempferol and Erysolin at different concentration levels. The molecular pathways which are regulated by Arugula include WNT Beta Catenin Signaling, Cell Cycle, Epithelial to Mesenchymal Transition, RAS-RAF Signaling, Stem Cell Signaling, MYC Signaling, MAPK Signaling and P53 Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Arugula individually or in combination is an important decision to be made. When making decisions on the use of supplement Arugula for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Arugula use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Arugula Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Arugula for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Arugula may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Arugula should be avoided or not and why.
1. Will Arugula Supplements benefit Cancer Patients with Desmoid Tumor Patients undergoing Doxorubicin treatment?
Desmoid Tumor is characterized and driven by specific genetic mutations like CTNNB1 and SOS2 leading to biochemical pathway changes in WNT Beta Catenin Signaling, MYC Signaling, Epithelial to Mesenchymal Transition and Adherens junction. A cancer treatment like Doxorubicin works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Arugula should be avoided for Desmoid Tumor along with treatment Doxorubicin. Arugula impacts pathways/processes like WNT Beta Catenin Signaling and Epithelial to Mesenchymal Transition which either promote drivers of the disease and/or nullify the treatment effect. Additionally, Arugula supplements contain active ingredients like Kaempferol which have CYP3A4 interaction with the Doxorubicin treatment, and hence should be avoided. (Pius S. Fasinu et al, Front Oncol., 2019; Ji-Won Park et al, Chin J Nat Med, 2019 ) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Arugula Supplements benefit Cancer Patients with Juvenile Myelomonocytic Leukemia Patients undergoing Trametinib Treatment?
Juvenile Myelomonocytic Leukemia is characterized and driven by specific genetic mutations like PTPN11 and NRAS leading to biochemical pathway changes in RAS-RAF Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling. A cancer treatment like Trametinib works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Arugula supplement should be considered for Juvenile Myelomonocytic Leukemia along with treatment Trametinib. Arugula supplement impacts pathways/processes like MAPK Signaling and MYC Signaling which either obstruct drivers of the Juvenile Myelomonocytic Leukemia and/or improve the treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Arugula Supplements Safe for Healthy Individuals with CDH1 Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. CDH1 is one of the genes generally available in panels for cancer risk testing.
CDH1 mutation causes biochemical pathways WNT Beta Catenin Signaling, Stem Cell Signaling, Adherens junction, Epithelial to Mesenchymal Transition and Estrogen Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Arugula should be avoided when the genetic panel identifies mutation of CDH1 for Breast Cancer and Gastric Cancer. Arugula impacts pathways/processes like WNT Beta Catenin Signaling and Epithelial to Mesenchymal Transition and creates adverse effects with CDH1 and related conditions.
4. Are Arugula Supplements Safe for Healthy Individuals with CDKN2A Mutation Associated Genetic Risk?
CDKN2A is one of the genes available in panels for cancer risk testing. CDKN2A mutation causes biochemical pathways like Stem Cell Signaling, P53 Signaling, MAPK Signaling and Cell Cycle to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Arugula supplements when the genetic panel identifies mutation in CDKN2A for Skin Cancer and Head And Neck Squamous Cell Carcinoma. Arugula impacts pathways/processes like Cell Cycle and P53 Signaling and creates an additive effect with CDKN2A and related conditions.
* Other Factors are also included like BMI, Lifestyle Habits, Treatments
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Arugula, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.