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is the most common question asked by cancer patients.
Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

is the most common question asked by cancer patients. Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

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Get your personalized nutrition plan for cancer at

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Use of Low Dose Salicylic Acid / Aspirin in Cancer Patients

May 27, 2021

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Highlights

Use of low-dose Aspirin/Salicylic acid in older individuals has been associated with lower risk of cancer incidence and has been proposed as a strategy for cancer prevention. A PLOC cancer screening trial analysis by the National Cancer Institute in the US has shown a strong association between use of low-dose Aspirin 3 or more times a week and reduced risk of cancer mortality and all-cause mortality in older individuals.



Aspirin/Salicylic Acid

Aspirin, extracted from the bark of Willow trees and first synthesized over 120 years ago, is a widely used drug for fever reduction and mild to moderate pain relief. Aspirin/Salicylic acid is widely used as a preventative adjuvant in individuals with a cardiovascular disease risk and has also been associated with a reduced risk of cancer.

Aspirin/Salicylic Acid Use & Cancer Risk

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Use of Aspirin/Salicylic Acid in Cancer

A long-term follow up of clinical studies of aspirin/salicylic acid in prevention of cardiovascular events showed that aspirin/salicylic acid use also reduced the risk of colorectal/colon cancer and several other cancers and risk of spread of cancer (metastasis) (Algra AM et al, The Lancet Oncol., 2012). Additionally, Professor Jack Cuzick, from the Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine in London, in an article in the Lancet Oncology in 2017, outlined various strategies for cancer prevention that included the use of low-dose Aspirin in older individuals along with weight control and physical activity. (Cuzick J, The Lancet Oncol, 2017)

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Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial


Another recently published analysis from a large clinical study – Prostate,Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, done by the Division of Cancer Prevention at the National Cancer Institute, United States, examined the association of Aspirin/salicylic acid use and risk of all-cause mortality, cancer related mortality and mortality linked to gastrointestinal and colorectal/colon cancers (Loomans-Kropp HA et al, JAMA Network Open, 2019). They examined 146,152 individuals in this study, with 51% women, aged more than 65 years. The results of the study are summarized below:

  • Use of low dose Aspirin 1-3 times a month was associated with reduced risk of death related to all causes as well as cancer.
  • Use of low dose Aspirin greater than 3 or more times per week was associated with reduced risk of all-cause mortality, cancer mortality, and mortality related to colorectal/colon cancers and gastrointestinal cancers.
  • Use of low-dose Aspirin 3 or more times a week in individuals with a body mass index (BMI – calculated as weight in kilograms divided by height in meters squared) of 20 to 24.9 was associated with reduced risk of all-cause and cancer mortality.
  • Among obese or overweight individuals with a BMI of 25 to 25.99, use of Aspirin more than 3 times a week also showed a reduced risk of cancer mortality.

Aspirin for Cancer Prevention

In summary, Aspirin is prescribed to older individuals who have a risk for cardiovascular disease. The data from this analysis and many others shows that use of low-dose Aspirin/Salicylic acid could also be used as a strategy for cancer prevention for older individuals who do not have a risk for cardiovascular or hypertension. The study also showed that use of low-dose Aspirin/Salicylic acid in individuals with gastric and colorectal/colon cancers is beneficial in lowering the risk of mortality with cancer.

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

Get started NOW with answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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