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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

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For Which Cancer Types Should I Avoid Aloe Vera Supplement?

May 26, 2021

Estimated reading time: 8 minutes
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Highlights

Nutritional supplements like Aloe Vera have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Aloe Vera supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”. 

Taking nutritional Aloe Vera supplements can benefit Urachal Adenocarcinoma patients on Cisplatin treatment. But avoid Aloe Vera supplements if on Etoposide treatment for Pineoblastoma. Similarly, taking nutritional supplement Aloe Vera can benefit healthy individuals who are at genetic risk of cancer due to mutation of the gene APC. But avoid taking nutritional supplement Aloe Vera when at genetic risk of cancer due to mutation of gene FANCC.

The takeaway being – your individual context will influence your decision if nutritional supplement Aloe Vera is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.



Brief Overview

Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements  are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose  the right combination of supplements like Aloe Vera based on individual context and conditions. 

Aloe vera supplements for Cancer Treatment and genetic Risk

So the question is should you take the supplement Aloe Vera? Should you take it when at genetic risk of cancer for mutation of gene FANCC? Should you take it when at genetic risk of cancer for mutation of the gene APC? Should you take it when diagnosed with Pineoblastoma? Should you take Aloe Vera supplement when diagnosed with Urachal Adenocarcinoma? Should you continue taking Aloe Vera supplement if you change your treatment from Etoposide to Cisplatin? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Aloe Vera. 

Cancer

Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Pineoblastoma or Urachal Adenocarcinoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Aloe Vera.

So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Aloe Vera? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene FANCC the same as due to mutation of gene APC? Are the implications of Pineoblastoma same as Urachal Adenocarcinoma? Is it one and the same if you are on treatment Etoposide or on Cisplatin? 

Aloe Vera – A Nutritional Supplement

Aloe Vera is a succulent medicinal plant with anti-inflammatory, anti-microbial, anti-viral, and antioxidant properties. Aloe vera is native to the Mediterranean region (North Africa), Southern Europe, and the Canary Islands though it grows in the dry and tropical climates worldwide. Oral intake of Aloe vera may help reduce blood sugar levels in diabetic people and may also help reduce cholesterol. However, oral aloe vera has a laxative effect and can lead to diarrhea. Additionally, aloe vera may interact with certain drugs and medications and may also stain the colon and should be avoided at least a month before colonoscopy.

Aloe Vera supplements contain many active ingredients including Acemannan, Barbaloin, Lupeol and Chrysophanol at different concentration levels. The molecular pathways which are regulated by Aloe Vera include PI3K-AKT-MTOR Signaling, Epithelial to Mesenchymal Transition, Estrogen Signaling, Nucleotide metabolism and DNA Repair. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Aloe Vera individually or in combination is an important decision to be made. When making decisions on the use of supplement Aloe Vera for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Aloe Vera use cannot be a one-size-fits-all decision for all types of cancers.

Choosing Aloe Vera Supplements for Your Cancer

The reason there is no easy way to answer the question “When should I avoid Aloe Vera for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Aloe Vera may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Aloe Vera should be avoided or not and why.

1. Will Aloe Vera Supplements benefit Pineoblastoma Patients undergoing Etoposide treatment?

Pineoblastoma is characterized and driven by specific genetic mutations like ATR and ATM leading to biochemical pathway changes in PI3K-AKT-MTOR Signaling, DNA Repair and EPHRIN Signaling. A cancer treatment like Etoposide works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Aloe Vera should be avoided for Pineoblastoma along with treatment Etoposide. Aloe Vera impacts pathways/processes like PI3K-AKT-MTOR Signaling and DNA Repair which either promote drivers of the disease and/or nullify the treatment effect. 

Additionally, Aloe Vera contains key active ingredients like Lupeol which have CYP1A2 interactions with Etoposide and hence should be avoided by cancer patients undergoing this treatment. (Xiuguo Li et al, Biopharm Drug Dispos., 2007; Madhav Seervi et al, Drug Metab Pers Ther., 2016) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).

2. Will Aloe Vera Supplements benefit Urachal Adenocarcinoma Patients undergoing Cisplatin Treatment?

Urachal Adenocarcinoma is characterized and driven by specific genetic mutations like TP53 and MTOR leading to biochemical pathway changes in Epithelial to Mesenchymal Transition, P53 Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling and Angiogenesis. A cancer treatment like Cisplatin works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Aloe Vera supplement should be considered for Urachal Adenocarcinoma along with treatment Cisplatin. Aloe Vera supplement impacts pathways/processes like Epithelial to Mesenchymal Transition and P53 Signaling which either obstruct drivers of the disease (Urachal Adenocarcinoma) and/or improve Cisplatin treatment effect. 

For Which Cancer to Avoid taking Supplement Aloe Vera

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Are Aloe Vera Supplements Safe for Healthy Individuals with FANCC Mutation Associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. FANCC is one of the genes generally available in panels for cancer risk testing.

FANCC mutation causes biochemical pathways Estrogen Signaling, Angiogenesis, Stem Cell Signaling, DNA Repair and Growth Factor Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Aloe Vera should be avoided when the genetic panel identifies mutation of FANCC for Breast Cancer. Aloe Vera impacts pathways/processes like Estrogen Signaling and Angiogenesis and creates adverse effects with FANCC and related conditions.

4. Are Aloe Vera Supplements Safe for Healthy Individuals with APC Mutation Associated Genetic Risk?

APC is one of the genes available in panels for cancer risk testing. APC mutation causes biochemical pathways Nucleotide metabolism, Stem Cell Signaling, WNT Beta-catenin Signaling, MYC Signaling and Angiogenesis to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Aloe Vera supplements when the genetic panel identifies mutation in APC for Colon Cancer. Aloe Vera impacts pathways/processes like Nucleotide metabolism and Stem Cell Signaling and creates a supportive effect with APC mutation and related conditions.

Which Cancer Types to Avoid Aloe Vera Supplement

* Other Factors are also included like BMI, Lifestyle Habits, Treatments

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Aloe Vera, is an effective tool which can be controlled by you, while facing cancer.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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