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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

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For Which Cancer Types Should I Avoid Rutin Supplement?

May 25, 2021

Estimated reading time: 9 minutes
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Highlights

Nutritional supplements like Rutin have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Rutin supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”. 

Taking nutritional Rutin supplements can benefit Diffuse Large B-Cell Lymphoma (DLBCL – Relapsed Refractory) cancer patients on Prednisone treatment. But avoid Rutin supplements if on Paclitaxel treatment for Adenoid Cystic Carcinoma. Similarly, taking nutritional supplement Rutin can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene MAX. But avoid taking nutritional supplement Rutin when at genetic risk of cancer due to mutation of gene MRE11.

The takeaway being – your individual context will influence your decision if nutritional supplement Rutin is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.



Brief Overview

Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements  are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose  the right combination of supplements like Rutin based on individual context and conditions. 

Rutin Supplements for Cancer Treatment and genetic Risk

So the question is should you take the supplement Rutin? Should you take it when at genetic risk of cancer for mutation of gene MRE11? Should you take it when at genetic risk of cancer for mutation of gene MAX? Should you take it when diagnosed with Adenoid Cystic Carcinoma? Should you take Rutin supplement when diagnosed with Diffuse Large B-Cell Lymphoma (DLBCL – Relapsed Refractory)? Should you take it when on Paclitaxel treatment? Should you continue taking it if you change your treatment from Paclitaxel to Prednisone? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Rutin. 

Cancer

Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Adenoid Cystic Carcinoma or Diffuse Large B-Cell Lymphoma (DLBCL – Relapsed Refractory), the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Rutin.

So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Rutin? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene MRE11 the same as due to mutation of gene MAX? Are the implications of Adenoid Cystic Carcinoma same as Diffuse Large B-Cell Lymphoma (DLBCL – Relapsed Refractory)? Is it one and the same if you are on treatment with Paclitaxel or on Prednisone? 

Rutin – A Nutritional Supplement

Rutin is a flavonoid that is abundantly found in different plants including certain vegetables and fruits. It is also known as rutoside, quercetin-3-rutinoside, and sophorin. It is considered to have antioxidant, neuroprotective and cardioprotective activities. Following are some of the potential health benefits of Rutin:

  • May strengthen blood vessels and improve circulation
  • May reduce swelling in the arms or legs due to damage to the lymph system
  • May reduce cholesterol
  • May reduce blood clots
  • May reduce osteoarthritis pain

However, Rutin supplement intake may lead to certain side-effects in some people such as:

  • Headache
  • Heaviness in legs
  • Skin Rashes
  • Stomach upset
  • Blurred vision
  • Muscle Stiffness
  • Flushed skin
  • Slow or fast heartbeats
  • Fluid accumulation in your knees, feet and ankles

Rutin is an active ingredient found in various food items. Black Tea, Green Tea and Buckwheat contain Rutin at different concentration levels along with other active ingredients. The molecular pathways which are regulated by Rutin include Focal Adhesion, Epithelial to Mesenchymal Transition, Estrogen Signaling, Cell Cycle and NFKB Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Rutin individually or in combination is an important decision to be made. When making decisions on the use of supplement Rutin for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Rutin use cannot be a one-size-fits-all decision for all types of cancers.

Choosing Rutin Supplements for Your Cancer

The reason there is no easy way to answer the question “When should I avoid Rutin for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Rutin may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Rutin should be avoided or not and why.

1. Will Rutin Supplements benefit Adenoid Cystic Carcinoma Patients undergoing Paclitaxel Cancer treatment?

Adenoid Cystic Carcinoma is characterized and driven by specific genetic mutations like NFIB and MYB leading to biochemical pathway changes in Focal Adhesion, PI3K-AKT-MTOR Signaling, Notch Signaling and Cholesterol Metabolism. A cancer treatment like Paclitaxel works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Rutin should be avoided for Adenoid Cystic Carcinoma along with treatment Paclitaxel. Rutin impacts pathways/processes like Focal Adhesion which either promote drivers of the disease and/or nullify the treatment effect. Additionally, Rutin supplements have CYP3A4 interactions with Paclitaxel treatment, and hence should be avoided by cancer patients undergoing this treatment. (Sedar Karakurt, Acta Pharm., 2016; Pius S Fasinu et al, Front Oncol., 2019) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).

2. Will Rutin Supplements benefit Diffuse Large B-Cell Lymphoma (DLBCL – Relapsed Refractory) Cancer Patients undergoing Prednisone Treatment?

Diffuse Large B-Cell Lymphoma (DLBCL – Relapsed Refractory) is characterized and driven by specific genetic mutations like CREBBP and KMT2D leading to biochemical pathway changes in Epithelial to Mesenchymal Transition, NFKB Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling. A cancer treatment like Prednisone works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Rutin supplements should be considered for Diffuse Large B-Cell Lymphoma (DLBCL – Relapsed Refractory) along with treatment Prednisone. Rutin supplements impact pathways/processes like Epithelial to Mesenchymal Transition and NFKB Signaling which either obstruct drivers of Diffuse Large B-Cell Lymphoma (DLBCL – Relapsed Refractory) disease and/or improve the treatment effect. 

For Which Cancer to Avoid taking Supplement Rutin

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Are Rutin Supplements Safe for Healthy Individuals with MRE11 Mutation Associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. MRE11 is one of the genes generally available in panels for cancer risk testing.

MRE11 mutation causes biochemical pathways Estrogen Signaling, DNA Repair, Stem Cell Signaling, Angiogenesis and Growth Factor Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Rutin should be avoided when the genetic panel identifies mutation of MRE11 for Breast Cancer. Rutin impacts pathways/processes like Estrogen Signaling and DNA Repair and creates adverse effects with MRE11 and related conditions.

4. Are Rutin Supplements Safe for Healthy Individuals with MAX Mutation Associated Genetic Risk?

MAX is one of the genes available in panels for cancer risk testing. MAX mutation causes biochemical pathways/processes like Cell Cycle, Angiogenesis, Stem Cell Signaling, MAPK Signaling and MYC Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Rutin supplements when the genetic panel identifies mutation in MAX for Neuroendocrine Cancer. Rutin impacts pathways/processes like Cell Cycle and Angiogenesis and creates a supportive effect in those with MAX and related conditions. 

Which Cancer Types to Avoid Rutin Supplement

* Other Factors are also included like BMI, Lifestyle Habits, Treatments

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Rutin, is an effective tool which can be controlled by you, while facing cancer.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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