Nutritional supplements like Rosmarinic Acid have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Rosmarinic Acid supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Rosmarinic Acid supplements can benefit Renal Non-Clear Cell Carcinoma patients on Bevacizumab cancer treatment. But avoid Rosmarinic Acid supplements if on Palbociclib treatment for ER PR +ve HER2 -ve Breast Carcinoma . Similarly, taking nutritional supplement Rosmarinic Acid can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene PTEN. But avoid taking nutritional supplement Rosmarinic Acid when at genetic risk of cancer due to mutation of gene MEN1.
The takeaway being – your individual context will influence your decision if nutritional supplement Rosmarinic Acid is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Rosmarinic Acid based on individual context and conditions.
So the question is should you take the supplement Rosmarinic Acid? Should you take it when at genetic risk of cancer for mutation of gene MEN1? Should you take it when at genetic risk of cancer for mutation of gene PTEN? Should you take it when diagnosed with ER PR +ve HER2 -ve Breast Carcinoma ? Should you take Rosmarinic Acid supplement when diagnosed with Renal Non-Clear Cell Carcinoma/Cancer? Should you take it when on Palbociclib treatment? Should you continue taking it if you change your treatment from Palbociclib to Bevacizumab? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Rosmarinic Acid.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as ER PR +ve HER2 -ve Breast Carcinoma or Renal Non-Clear Cell Carcinoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Rosmarinic Acid.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Rosmarinic Acid? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene MEN1 the same as due to mutation of gene PTEN? Are the implications of ER PR +ve HER2 -ve Breast Carcinoma same as Renal Non-Clear Cell Carcinoma? Is it one and the same if you are on treatment with Palbociclib or on Bevacizumab?
Rosmarinic Acid – A Nutritional Supplement
Rosmarinic acid is polyphenol found in high levels in plants like Rosemary. Rosmarinic acid is known to have antiviral, antibacterial, anti inflammatory and antioxidant properties.(Maike Petersen and Monique S J Simmonds, Phytochemistry., 2003) It is also used in the food industry as a preservative in meat as it prevents oxidation. Some of the purported uses of rosmarinic acid include:
- May reduce pain
- May reduce inflammation
- May improve blood vessel health
Rosmarinic Acid is an active ingredient found in various food items. Rosemary, Basil, Cornmint and Hyssop contain Rosmarinic Acid at different concentration levels along with other active ingredients. The molecular pathways which are regulated by Rosmarinic Acid include Estrogen Signaling, Oxidative Stress, MAPK Signaling, Autophagy and Angiogenesis. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Rosmarinic Acid individually or in combination is an important decision to be made. When making decisions on the use of the supplement Rosmarinic Acid for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Rosmarinic Acid use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Rosmarinic Acid Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Rosmarinic Acid for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Rosmarinic Acid may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Rosmarinic Acid should be avoided or not and why.
1. Will Rosmarinic Acid Supplements benefit ER PR +ve HER2 -ve Breast Carcinoma Patients undergoing Palbociclib cancer treatment?
ER PR +ve HER2 -ve Breast Carcinoma is characterized and driven by specific genetic mutations like ESR1 and NR3C3 leading to biochemical pathway changes in Estrogen Signaling, PI3K-AKT-MTOR Signaling and Inositol Phosphate Signaling. A cancer treatment like Palbociclib works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Rosmarinic Acid should be avoided for ER PR +ve HER2 -ve Breast Carcinoma along with treatment Palbociclib. Rosmarinic Acid impacts pathways/processes like Estrogen Signaling which either promote drivers of the disease and/or nullify the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Rosmarinic Acid Supplements benefit Renal Non-Clear Cell Carcinoma Patients undergoing Bevacizumab Cancer Treatment?
Renal Non-Clear Cell Carcinoma is characterized and driven by specific genetic mutations like MUC16 and TP53 leading to biochemical pathway changes in Oxidative Stress, MAPK Signaling, Extracellular Matrix Remodelling, Small Molecule Transport and PI3K-AKT-MTOR Signaling. A cancer treatment like Bevacizumab works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Rosmarinic Acid should be considered for Renal Non-Clear Cell Carcinoma/Cancer along with treatment Bevacizumab. Rosmarinic Acid impacts pathways/processes like Oxidative Stress and MAPK Signaling which either obstruct drivers of the disease (Renal Non-Clear Cell Carcinoma/Cancer) and/or improve the treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Rosmarinic Acid Supplements Safe for Healthy Individuals with MEN1 Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. MEN1 is one of the genes generally available in panels for cancer risk testing.
MEN1 mutation causes biochemical pathways MAPK Signaling, Stem Cell Signaling, NFKB Signaling, Cell Cycle and WNT Betacatenin Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Rosmarinic Acid should be avoided when the genetic panel identifies mutation of MEN1 for Thyroid Cancer and Neuroendocrine Cancer. Rosmarinic Acid impacts pathways/processes like MAPK Signaling and Stem Cell Signaling and creates adverse effects with MEN1 and related conditions.
4. Are Rosmarinic Acid Supplements Safe for Healthy Individuals with PTEN Mutation Associated Genetic Risk?
PTEN is one of the genes available in panels for cancer risk testing. PTEN mutation causes biochemical pathways/processes like Autophagy, Estrogen Signaling, Insulin Signaling, Stem Cell Signaling and Endoplasmic Reticulum Stress to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Rosmarinic Acid Supplements when the genetic panel identifies mutation in PTEN for Breast Cancer and Kidney Cancer. Rosmarinic Acid impacts pathways/processes like Autophagy and Estrogen Signaling and creates a supportive effect in those with PTEN and related conditions.
* Other Factors are also included like BMI, Lifestyle Habits, Treatments
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Rosmarinic Acid, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Foods to Eat After Cancer Diagnosis!
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.