Nutritional supplements like Osha Root have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Osha Root supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Osha Root supplements can benefit Renal Non-Clear Cell Carcinoma patients on Bevacizumab cancer treatment. But avoid Osha Root supplements if on Cisplatin treatment for Adenoid Cystic Carcinoma. Similarly, taking nutritional supplement Osha Root can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene LZTR1. But avoid taking nutritional supplement Osha Root when at genetic risk of cancer due to mutation of gene TSC1.
The takeaway being – your individual context will influence your decision if nutritional supplement Osha Root is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Osha Root based on individual context and conditions.
So the question is should you take the supplement Osha Root? Should you take it when at genetic risk of cancer for mutation of gene TSC1? Should you take it when at genetic risk of cancer for mutation of gene LZTR1? Should you take it when diagnosed with Adenoid Cystic Carcinoma? Should you take Osha Root supplement when diagnosed with Renal Non-Clear Cell Carcinoma/Cancer? Should you take it when on Cisplatin treatment? Should you continue taking it if you change your treatment from Cisplatin to Bevacizumab? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Osha Root.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Adenoid Cystic Carcinoma or Renal Non-Clear Cell Carcinoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Osha Root.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Osha Root? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene TSC1 the same as due to mutation of gene LZTR1? Are the implications of Adenoid Cystic Carcinoma same as Renal Non-Clear Cell Carcinoma? Is it one and the same if you are on treatment with Cisplatin or on Bevacizumab?
Osha Root – A Nutritional Supplement
Osha is a perennial herb which grows at higher elevations in the Western US and is considered to have medicinal properties. Its root is known to have antiviral, anti-bacterial, anti-fungal and anti-inflammatory activities. It has been traditionally used for the treatment of different respiratory conditions.
Osha Root supplements contain many active ingredients including Ligustilide at different concentration levels. The molecular pathways which are regulated by Osha Root include Oxidative Stress, Cytoskeletal Dynamics, Autophagy, Hypoxia and Endoplasmic Reticulum Stress. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Osha Root individually or in combination is an important decision to be made. When making decisions on the use of supplement Osha Root for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Osha Root use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Osha Root Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Osha Root for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Osha Root may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Osha Root should be avoided or not and why.
1. Will Osha Root Supplements benefit Adenoid Cystic Carcinoma Patients undergoing Cisplatin Cancer treatment?
Adenoid Cystic Carcinoma is characterized and driven by specific genetic mutations like NFIB and MYB leading to biochemical pathway changes in Oxidative Stress, PI3K-AKT-MTOR Signaling, Notch Signaling and Cholesterol Metabolism. A cancer treatment like Cisplatin works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Osha Root should be avoided for Adenoid Cystic Carcinoma along with treatment Cisplatin. Osha Root impacts pathways/processes like Oxidative Stress which either promote drivers of the disease and/or nullify the treatment effect. Additionally, Osha Root contains active ingredients like Ligustilide which have CYP3A4 (drug metabolizing enzyme) interactions with Cisplatin treatment, and hence should be avoided by cancer patients undergoing this treatment. (Chunna Yu et al, J Ethnopharmacol., 2011; Pius S Fasinu et al, Front Oncol., 2019) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Osha Root Supplements benefit Renal Non-Clear Cell Carcinoma/Cancer Patients undergoing Bevacizumab Treatment?
Renal Non-Clear Cell Carcinoma is characterized and driven by specific genetic mutations like MUC16 and TP53 leading to biochemical pathway changes in Cytoskeletal Dynamics, Hypoxia, Oxidative Stress, Small Molecule Transport and PI3K-AKT-MTOR Signaling. A cancer treatment like Bevacizumab works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Osha Root should be considered for Renal Non-Clear Cell Carcinoma/Cancer along with treatment Bevacizumab. Osha Root impacts pathways/processes like Cytoskeletal Dynamics and Hypoxia which either obstruct drivers of the disease (Renal Non-Clear Cell Carcinoma/Cancer) and/or improve the treatment effect.
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3. Are Osha Root Supplements Safe for Healthy Individuals with TSC1 Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. TSC1 is one of the genes generally available in panels for cancer risk testing.
TSC1 mutation causes biochemical pathways Autophagy, Endoplasmic Reticulum Stress, Stem Cell Signaling, PI3K-AKT-MTOR Signaling and Nutrient sensing to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Osha Root should be avoided when the genetic panel identifies mutation of TSC1 for Kidney Cancer. Osha Root impacts pathways/processes like Autophagy and Endoplasmic Reticulum Stress and creates adverse effects with TSC1 and related conditions.
4. Are Osha Root Supplements Safe for Healthy Individuals with LZTR1 Mutation Associated Genetic Risk?
LZTR1 is one of the genes available in panels for cancer risk testing. LZTR1 mutation causes biochemical pathways Hypoxia, Angiogenesis, Nucleotide metabolism, Stem Cell Signaling and RAS-RAF Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Osha Root supplements when the genetic panel identifies mutation in LZTR1 for Central Nervous System and Hematological Cancer. Osha Root impacts pathways/processes like Hypoxia and Angiogenesis and creates a supportive effect on those with LZTR1 and related conditions.
* Other Factors are also included like BMI, Lifestyle Habits, Treatments
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Osha Root, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.