Nutritional supplements like Luteolin have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Luteolin supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Luteolin supplements can benefit Primary Central Nervous System Lymphoma patients on Epirubicin cancer treatment. But avoid Luteolin supplements if on Dexamethasone treatment for Aggressive Natural Killer Cell Leukemia. Similarly, taking nutritional supplement Luteolin can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene CDK4. But avoid taking nutritional supplement Luteolin when at genetic risk of cancer due to mutation of gene POLE.
The takeaway being – your individual context will influence your decision if nutritional supplement Luteolin is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Luteolin based on individual context and conditions.
So the question is should you take the supplement Luteolin? Should you take it when at genetic risk of cancer for mutation of gene POLE? Should you take it when at genetic risk of cancer for mutation of gene CDK4? Should you take it when diagnosed with Aggressive Natural Killer Cell Leukemia? Should you take it when diagnosed with Primary Central Nervous System Lymphoma? Should you take it when on Dexamethasone treatment? Should you continue taking Luteolin supplement if you change your treatment from Dexamethasone to Epirubicin? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Luteolin.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available.
After diagnosis with cancer such as Aggressive Natural Killer Cell Leukemia or Primary Central Nervous System Lymphoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Luteolin.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Luteolin? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene POLE the same as due to mutation of gene CDK4? Are the implications of Aggressive Natural Killer Cell Leukemia same as Primary Central Nervous System Lymphoma? Is it one and the same if you are on treatment with Dexamethasone or on Epirubicin?
Luteolin – A Nutritional Supplement
Luteolin is a flavonoid, with strong antioxidant and anti-inflammatory properties. Luteolin – containing plants have been commonly used in Chinese Traditional Medicine for treating various health conditions such as hypertension and inflammatory disorders. Following are some of the potential health benefits of Luteolin:
- May support memory
- May support nervous system
- May improve heart health
- May reduce inflammation and allergies
Luteolin supplements should be avoided by autistic children, people with colitis, and pregnant women.
Luteolin is an active ingredient found in various food items. Angelica, Anise and Common Verbena contain Luteolin at different concentration levels along with other active ingredients. The molecular pathways which are regulated by Luteolin include MYC Signaling, Cell Cycle, Stem Cell Signaling, MAPK Signaling and Apoptosis. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Luteolin individually or in combination is an important decision to be made. When making decisions on the use of supplement Luteolin for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Luteolin use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Luteolin Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Luteolin for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Luteolin may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Luteolin should be avoided or not and why.
1. Will Luteolin Supplements benefit Cancer Patients with Aggressive Natural Killer Cell Leukemia undergoing Dexamethasone treatment?
Aggressive Natural Killer Cell Leukemia is characterized and driven by specific genetic mutations like DDX3X and STAT3 leading to biochemical pathway changes in MYC Signaling, Interferon Signaling, JAK-STAT Signaling and MAPK Signaling. A cancer treatment like Dexamethasone works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Luteolin should be avoided for Aggressive Natural Killer Cell Leukemia along with treatment Dexamethasone. Luteolin impacts pathways/processes like MYC Signaling which either promote drivers of the disease and/or nullify the treatment effect. Additionally, Luteolin supplements have CYP3A4 interactions with Dexamethasone treatment, and hence should be avoided by cancer patients . (Luigi Quintieri et al, Biochem Pharmacol., 2008) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Luteolin Supplements benefit Cancer Patients with Primary Central Nervous System Lymphoma undergoing Epirubicin Treatment?
Primary Central Nervous System Lymphoma is characterized and driven by specific genetic mutations like MYD88 and CD79B leading to biochemical pathway changes in Cell Cycle, NFKB Signaling, Apoptosis, B Cell Receptor Signaling and RAS-RAF Signaling. A cancer treatment like Epirubicin works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Luteolin supplements should be considered for Primary Central Nervous System Lymphoma along with treatment Epirubicin. Luteolin supplement impacts pathways/processes like Cell Cycle and NFKB Signaling which either obstruct drivers of the disease and/or improve the Epirubicin treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Luteolin Supplements Safe for Healthy Individuals with POLE Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives.
POLE is one of the genes generally available in panels for cancer risk testing. POLE mutation causes biochemical pathways Stem Cell Signaling, MYC Signaling, Nucleotide metabolism, Lipid Metabolism and DNA Repair to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Luteolin should be avoided when the genetic panel identifies mutation of POLE for Colon Cancer. Luteolin impacts pathways/processes like Stem Cell Signaling and MYC Signaling and creates adverse effects with POLE and related conditions.
4. Are Luteolin Supplements Safe for Healthy Individuals with CDK4 Mutation Associated Genetic Risk?
CDK4 is one of the genes available in panels for cancer risk testing. CDK4 mutation causes biochemical pathways/processes like MAPK Signaling, Cell Cycle, Stem Cell Signaling, Cell Cycle Checkpoints and DNA Repair to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Luteolin supplements when the genetic panel identifies mutations in CDK4 for Skin Cancer. Luteolin impacts pathways/processes like MAPK Signaling and Cell Cycle and creates a supportive effect in those with CDK4 mutation and related conditions.
* Other Factors are also included like BMI, Lifestyle Habits, Treatments
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Luteolin, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.