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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

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For Which Cancer Types Should I Avoid Lemon Supplement?

May 21, 2021

Estimated reading time: 8 minutes
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Highlights

Nutritional supplements like Lemon have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Lemon supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”. 

Taking nutritional Lemon supplements can benefit Juvenile Myelomonocytic Leukemia patients on Trametinib cancer treatment. But avoid Lemon supplements if on Paclitaxel treatment for Adenoid Cystic Carcinoma. Similarly, taking nutritional supplement Lemon can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene MAX. But avoid taking nutritional supplement Lemon when at genetic risk of cancer due to mutation of gene SDHA.

The takeaway being – your individual context will influence your decision if nutritional supplement Lemon is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context. 



Brief Overview

Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements  are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose  the right combination of supplements like Lemon based on individual context and conditions. 

Lemon Supplements for Cancer Treatment and genetic Risk

So the question is should you take the supplement Lemon? Should you take it when at genetic risk of cancer for mutation of the gene SDHA? Should you take it when at genetic risk of cancer for mutation of gene MAX? Should you take it when diagnosed with Adenoid Cystic Carcinoma? Should you take Lemon supplement when diagnosed with Juvenile Myelomonocytic Leukemia? Should you continue taking it if you change your treatment from Paclitaxel to Trametinib? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Lemon. 

Cancer

Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Adenoid Cystic Carcinoma or Juvenile Myelomonocytic Leukemia, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Lemon.

So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Lemon? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene SDHA the same as due to mutation of gene MAX? Are the implications of Adenoid Cystic Carcinoma same as Juvenile Myelomonocytic Leukemia? Is it one and the same if you are on treatment Paclitaxel or on Trametinib? 

Lemon – A Nutritional Supplement

Lemon is a very popular citrus fruit loaded with antioxidants like Vitamin C and bioflavonoids. Due to its antioxidant and antimicrobial properties, Lemon intake may help prevent diseases, boost health and offer several health benefits. Following are some of the potential health benefits of lemon.

  • Prevent scurvy (Vitamin C deficiency)
  • Boost immunity 
  • Improve heart health
  • Help in weight loss
  • Reduce kidney stones
  • Improve skin health
  • Reduce morning sickness

Lemon supplements contain many active ingredients including Vitamin C, Citric Acid, Modified Citrus Pectin, Hesperetin, Hesperidin, D-Limonene, P-coumaric Acid, Geraniin, Retinol and Eriodictyol at different concentration levels. The molecular pathways which are regulated by Lemon include Focal Adhesion, RAS-RAF Signaling, Carbohydrate Metabolism, Stem Cell Signaling and MAPK Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Lemon individually or in combination is an important decision to be made. When making decisions on the use of supplement Lemon for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Lemon use cannot be a one-size-fits-all decision for all types of cancers.

Choosing Lemon Supplements for Your Cancer

The reason there is no easy way to answer the question “When should I avoid Lemon for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Lemon may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Lemon should be avoided or not and why.

1. Will Lemon Supplements benefit Adenoid Cystic Carcinoma Patients undergoing Paclitaxel Cancer treatment?

Adenoid Cystic Carcinoma is characterized and driven by specific genetic mutations like NFIB and MYB leading to biochemical pathway changes in Focal Adhesion, Carbohydrate Metabolism, PI3K-AKT-MTOR Signaling, Notch Signaling and Cholesterol Metabolism. A cancer treatment like Paclitaxel works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Lemon should be avoided for Adenoid Cystic Carcinoma along with treatment Paclitaxel. Lemon impacts pathways/processes like Focal Adhesion and Carbohydrate Metabolism which either promote drivers of the disease and/or nullify the treatment effect. Additionally, Lemon has many key ingredients like Caffeine, Hesperetin, Hesperidin and Retinol which have CYP3A4 interactions with Paclitaxel treatment and hence should be avoided by cancer patients undergoing this treatment. (Pius S Fasinu et al, Front Oncol., 2019; V Sridhar et al, Phytother Res., 2014; Melanie Z Sakatis et al, Chem Res Toxicol., 2012) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).

2. Will Lemon Supplements benefit Juvenile Myelomonocytic Leukemia Patients undergoing Trametinib Cancer Treatment?

Juvenile Myelomonocytic Leukemia is characterized and driven by specific genetic mutations like PTPN11 and NRAS leading to biochemical pathway changes in RAS-RAF Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling. A cancer treatment like Trametinib works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Lemon supplements should be considered for Juvenile Myelomonocytic Leukemia along with treatment Trametinib. Lemon supplements impact pathways like RAS-RAF Signaling and MAPK Signaling which either obstruct drivers of the disease (Juvenile Myelomonocytic Leukemia) and/or improve the treatment effect. 

For Which Cancer to Avoid taking Supplement Lemon

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Are Lemon Supplements Safe for Healthy Individuals with SDHA Mutation Associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. SDHA is one of the genes generally available in panels for cancer risk testing.

SDHA mutation causes biochemical pathways Carbohydrate Metabolism, Energy Metabolism, Stem Cell Signaling, Hypoxia and MAPK Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Lemon should be avoided when the genetic panel identifies mutation of SDHA for Thyroid Cancer and Neuroendocrine Cancer. Lemon impacts pathways like Carbohydrate Metabolism and Energy Metabolism and creates adverse effects with SDHA and related conditions.

4. Are Lemon Supplements Safe for Healthy Individuals with MAX Mutation Associated Genetic Risk?

MAX is one of the genes available in panels for cancer risk testing. MAX mutation causes biochemical pathways Stem Cell Signaling, MAPK Signaling, Cell Cycle, MYC Signaling and Angiogenesis to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Lemon supplements when the genetic panel identifies mutation in MAX for Neuroendocrine Cancer. Lemon impacts pathways like Stem Cell Signaling and MAPK Signaling and creates a supportive effect in those with MAX mutation and related conditions. 

Which Cancer Types to Avoid Lemon Supplement

* Other Factors are also included like BMI, Lifestyle Habits, Treatments

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Lemon, is an effective tool which can be controlled by you, while facing cancer.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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