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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

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For Which Cancer Types Should I Avoid Green Tea Supplement?

May 21, 2021

Estimated reading time: 9 minutes
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Highlights

Nutritional supplements like Green Tea have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Green Tea supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”. 

Taking nutritional Green Tea supplements can benefit ALK +ve Non-Small Cell Lung Cancer patients on Alectinib treatment. But avoid Green Tea supplements if on Paclitaxel treatment for Adenoid Cystic Carcinoma. Similarly, taking the nutritional supplement Green Tea can benefit healthy individuals who are at genetic risk of cancer due to mutation of the gene CDKN1B. But avoid taking nutritional supplement Green Tea when at genetic risk of cancer due to mutation of the gene RAD50.

The takeaway being – your individual context will influence your decision if the nutritional supplement Green Tea is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.



Brief Overview

Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements  are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose  the right combination of supplements like Green Tea based on individual context and conditions. 

Green Tea Supplements for Cancer Treatment and genetic Risk

So the question is should you take Green tea supplement? Should you take it when at genetic risk of cancer for mutation of gene RAD50? Should you take it when at genetic risk of cancer for mutation of gene CDKN1B? Should you take it when diagnosed with Adenoid Cystic Carcinoma? Should you take Green tea supplement when diagnosed with ALK +ve Non-Small Cell Lung Cancer? Should you take it when on Paclitaxel treatment? Should you continue taking it if you change your treatment from Paclitaxel to Alectinib? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Green Tea. 

Cancer

Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Adenoid Cystic Carcinoma or ALK +ve Non-Small Cell Lung Cancer , the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Green Tea.

So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Green Tea? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene RAD50 the same as due to mutation of gene CDKN1B? Are the implications of Adenoid Cystic Carcinoma same as ALK +ve Non-Small Cell Lung Cancer? Is it one and the same if you are on treatment with Paclitaxel or on Alectinib?

Green Tea – A Nutritional Supplement

Green tea, made from the Camellia sinensis plant, is packed with antioxidants and beneficial polyphenols. Green tea also has strong anti-inflammatory properties. Following are some of the health benefits of Green tea:

  • May help improve cardiovascular health
  • May help in weight loss
  • May help reduce blood sugar levels
  • May help reduce bad cholesterol 
  • May help improve brain functions

Green Tea supplements contain many active ingredients including 3-hydroxyflavone, Glabridin, Rutin, Epicatechin, Epicatechin gallate, Epigallocatechin, Epigallocatechin gallate, Caffeine, Apiole and Beta-ionone at different concentration levels. The molecular pathways which are regulated by Green Tea include Focal Adhesion, Epithelial to Mesenchymal Transition, Angiogenesis, Stem Cell Signaling and RAS-RAF Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Green Tea individually or in combination is an important decision to be made. When making decisions on the use of supplement Green Tea for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Green Tea use cannot be a one-size-fits-all decision for all types of cancers.

Choosing Green Tea Supplements for Your Cancer

The reason there is no easy way to answer the question “When should I avoid Green Tea for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Green Tea may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Green Tea should be avoided or not and why.

1. Will Green Tea Supplements benefit Adenoid Cystic Carcinoma Patients undergoing Paclitaxel Cancer treatment?

Adenoid Cystic Carcinoma is characterized and driven by specific genetic mutations like NFIB and MYB leading to biochemical pathway changes in Focal Adhesion, PI3K-AKT-MTOR Signaling, Notch Signaling and Cholesterol Metabolism. A cancer treatment like Paclitaxel works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Green Tea should be avoided for Adenoid Cystic Carcinoma along with treatment Paclitaxel. Green Tea impacts pathways/processes like Focal Adhesion which either promote drivers of the disease and/or nullify the treatment effect. Additionally, Green Tea supplements contain active ingredients like 3-hydroxyflavone, Caffeine, Glabridin and Rutin which have CYP3A4 (drug metabolizing enzymes) interactions with Paclitaxel treatment, and hence should be avoided by cancer patients undergoing this treatment. (Pius S Fasinu et al, Front Oncol., 2019; Sedar Karakurt et al, Acta Pharm., 2016; Melanie Z Sakatis et al, Chem Res Toxicol., 2012) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).

2. Will Green Tea Supplements benefit ALK +ve Non-Small Cell Lung Cancer Patients undergoing Alectinib Treatment?

ALK +ve Non-Small Cell Lung Cancer is characterized and driven by specific genetic mutations like ALK and TP53 leading to biochemical pathway changes in Epithelial to Mesenchymal Transition, RAS-RAF Signaling, Inositol Phosphate Signaling, Small Molecule Transport and PI3K-AKT-MTOR Signaling. A cancer treatment like Alectinib works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Green Tea should be considered for ALK +ve Non-Small Cell Lung Cancer along with treatment Alectinib. Green Tea impacts pathways/processes like Epithelial to Mesenchymal Transition and RAS-RAF Signaling which either obstruct drivers of the disease (ALK +ve Non-Small Cell Lung Cancer) and/or improve the treatment effect. 

For Which Cancer to Avoid taking Supplement Green Tea

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Are Green Tea Supplements Safe for Healthy Individuals with RAD50 Mutation Associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. RAD50 is one of the genes generally available in panels for cancer risk testing.

RAD50 mutation causes biochemical pathways Angiogenesis, Estrogen Signaling, Stem Cell Signaling, DNA Repair and Growth Factor Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Green Tea should be avoided when the genetic panel identifies mutation of RAD50 for Breast Cancer. Green Tea impacts pathways like Angiogenesis and Estrogen Signaling and creates adverse effects with RAD50 and related conditions.

4. Are Green Tea Supplements Safe for Healthy Individuals with CDKN1B Mutation Associated Genetic Risk?

CDKN1B is one of the genes available in panels for cancer risk testing. CDKN1B mutation causes biochemical pathways Stem Cell Signaling, FOXO Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Green Tea supplements when the genetic panel identifies mutation in CDKN1B for Neuroendocrine Cancer. Green Tea impacts pathways like Stem Cell Signaling and FOXO Signaling and creates a supportive effect in those with CDKN1B and related conditions.

Which Cancer Types to Avoid Green Tea Supplement

* Other Factors are also included like BMI, Lifestyle Habits, Treatments

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Green Tea, is an effective tool which can be controlled by you, while facing cancer.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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