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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

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For Which Cancer Types Should I Avoid Epicatechin Supplement?

May 20, 2021

Estimated reading time: 8 minutes
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Highlights

Nutritional supplements like Epicatechin have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Epicatechin supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”. 

Taking nutritional Epicatechin supplements can benefit Oropharyngeal Cancer patients on Cisplatin treatment. But avoid Epicatechin supplements if on Tamoxifen treatment for Paget disease of the breast. Similarly, taking nutritional supplement Epicatechin can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene TP53. But avoid taking nutritional supplement Epicatechin when at genetic risk of cancer due to mutation of gene FANCC.

The takeaway being – your individual context will influence your decision if nutritional supplement Epicatechin is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context. 



Brief Overview

Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements  are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose  the right combination of supplements like Epicatechin based on individual context and conditions. 

Epicatechin Supplements for Cancer Treatment and genetic Risk

So the question is should you take the supplement Epicatechin? Should you take it when at genetic risk of cancer for mutation of gene FANCC? Should you take it when at genetic risk of cancer for mutation of gene TP53? Should you take it when diagnosed with Paget disease of the breast? Should you take Epicatechin supplements when diagnosed with Oropharyngeal Cancer? Should you take it when on Tamoxifen treatment? Should you continue taking it if you change your treatment from Tamoxifen to Cisplatin? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Epicatechin. 

Cancer

Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Paget disease of the breast or Oropharyngeal Cancer, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Epicatechin.

So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Epicatechin? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene FANCC the same as due to mutation of gene TP53? Are the implications of Paget disease of the breast same as Oropharyngeal Cancer? Is it one and the same if you are on treatment with Tamoxifen or on Cisplatin? 

Epicatechin – A Nutritional Supplement

Epicatechin is a flavonoid, a bioactive compound, found in fruits, dark chocolates and beverages. It has strong antioxidant properties with different health benefits. (Layth Abdulmajeed Abdulkhaleq et al, Vet World., 2017) Some of the potential health benefits of Epicatechin include: 

  • May help in reducing blood glucose levels
  • May help reduce blood pressure
  • May help improve heart health
  • May have anti-cancer properties

Green Tea, Oolong Tea and Apple contain Epicatechin at different concentration levels along with other active ingredients. The molecular pathways which are regulated by Epicatechin include Angiogenesis, P53 Signaling, DNA Repair, Estrogen Signaling and MAPK Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Epicatechin individually or in combination is an important decision to be made. When making decisions on the use of supplement Epicatechin for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Epicatechin use cannot be a one-size-fits-all decision for all types of cancers.

Choosing Epicatechin Supplements for Your Cancer

The reason there is no easy way to answer the question “When should I avoid Epicatechin for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Epicatechin may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Epicatechin should be avoided or not and why.

1. Will Epicatechin Supplements benefit Patients with Paget disease of the Breast undergoing Tamoxifen Cancer treatment?

Paget disease of the breast is characterized and driven by specific genetic mutations like TTN and MUC22 leading to biochemical pathway changes in Angiogenesis, PI3K-AKT-MTOR Signaling, MAPK Signaling and Cancer Epigenetics. A cancer treatment like Tamoxifen works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Epicatechin should be avoided for Paget disease of the breast along with treatment Tamoxifen. Epicatechin impacts pathways/processes like Angiogenesis which either promote drivers of the disease and/or nullify the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).

2. Will Epicatechin Supplements benefit Oropharyngeal Cancer Patients undergoing Cisplatin Treatment?

Oropharyngeal Cancer is characterized and driven by specific genetic mutations like TP53 and PIK3CA leading to biochemical pathway changes in P53 Signaling, DNA Repair, PI3K-AKT-MTOR Signaling and TGFB Signaling. A cancer treatment like Cisplatin works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Epicatechin supplements should be considered for Oropharyngeal Cancer along with treatment Cisplatin. Epicatechin supplements impact pathways like P53 Signaling and DNA Repair which either obstruct drivers of the disease (Oropharyngeal Cancer) and/or improve the treatment effect. 

For Which Cancer to Avoid taking Supplement Epicatechin

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Are Epicatechin Supplements Safe for Healthy Individuals with FANCC Mutation Associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. FANCC is one of the genes generally available in panels for cancer risk testing.

FANCC mutation causes biochemical pathways Angiogenesis, Estrogen Signaling, Growth Factor Signaling, DNA Repair and Stem Cell Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Epicatechin should be avoided when the genetic panel identifies mutation of FANCC for Breast Cancer. Epicatechin impacts pathways like Angiogenesis and Estrogen Signaling and creates adverse effects with FANCC and related conditions.

4. Are Epicatechin Supplements Safe for Healthy Individuals with TP53 Mutation Associated Genetic Risk?

TP53 is one of the genes available in panels for cancer risk testing. TP53 mutation causes biochemical pathways P53 Signaling, MAPK Signaling, Sirtuin Signaling, Growth Factor Signaling and DNA Repair to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Epicatechin supplements when the genetic panel identifies mutation in TP53 for Breast Cancer and Lung Cancer. Epicatechin impacts pathways like P53 Signaling and MAPK Signaling and creates a supportive effect in those with TP53 mutation and related conditions.

Which Cancer Types to Avoid Epicatechin Supplement

* Other Factors are also include like BMI, Lifestyle Habits, Treatments

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Epicatechin, is an effective tool which can be controlled by you, while facing cancer.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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