Nutritional supplements like Citrus Bioflavonoid have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Citrus Bioflavonoid supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Citrus Bioflavonoid supplements can benefit Diffuse Large B-Cell Lymphoma (Relapsed Refractory DLBCL) cancer patients on Prednisone treatment. But avoid Citrus Bioflavonoid supplements if on Pazopanib treatment for Desmoid Tumor. Similarly, taking nutritional supplement Citrus Bioflavonoid can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene TP53. But avoid taking nutritional supplement Citrus Bioflavonoid when at genetic risk of cancer due to mutation of gene CDH1.
The takeaway being – your individual context will influence your decision if nutritional supplement Citrus Bioflavonoid is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Citrus Bioflavonoid based on individual context and conditions.
So the question is should you take the supplement Citrus Bioflavonoid? Should you take it when at genetic risk of cancer for mutation of gene CDH1? Should you take it when at genetic risk of cancer for mutation of gene TP53? Should you take it when diagnosed with Desmoid Tumor? Should you take Citrus Bioflavonoid supplement when diagnosed with Diffuse Large B-Cell Lymphoma (Relapsed Refractory DLBCL)? Should you take it when on Pazopanib treatment? Should you continue taking it if you change your treatment from Pazopanib to Prednisone? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Citrus Bioflavonoid.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Desmoid Tumor or Diffuse Large B-Cell Lymphoma (Relapsed Refractory DLBCL), the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Citrus Bioflavonoid.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Citrus Bioflavonoid? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene CDH1 the same as due to mutation of gene TP53? Are the implications of Desmoid Tumor same as Diffuse Large B-Cell Lymphoma (Relapsed Refractory DLBCL)? Is it one and the same if you are on treatment Pazopanib or Prednisone?
Citrus Bioflavonoid – A Nutritional Supplement
Citrus Bioflavonoids are natural compounds found in citrus fruits like oranges, tangerines, lemons, grapefruits, pomelos, and limes. Citrus bioflavonoids have strong antioxidant properties and are considered to have many health-promoting benefits. Following are some of the potential health benefits of citrus bioflavonoids:
- May help improve blood circulation
- May help support a healthy immune system
- May help reduce swelling
- May help reduce blood pressure
Citrus Bioflavonoid supplements contain many active ingredients including Obacunone at different concentration levels. The molecular pathways which are regulated by Citrus Bioflavonoid include WNT Beta-catenin Signaling, MAPK Signaling, P53 Signaling and NFKB Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Citrus Bioflavonoid individually or in combination is an important decision to be made. When making decisions on the use of supplement Citrus Bioflavonoid for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Citrus Bioflavonoid use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Citrus Bioflavonoid Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Citrus Bioflavonoid for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Citrus Bioflavonoid may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Citrus Bioflavonoid should be avoided or not and why.
1. Will Citrus Bioflavonoid Supplements benefit Desmoid Tumor Patients undergoing Pazopanib Cancer treatment?
Desmoid Tumor is characterized and driven by specific genetic mutations like CTNNB1 and SOS2 leading to biochemical pathway changes in WNT Beta-catenin Signaling, Adherens junction and Epithelial to Mesenchymal Transition. A cancer treatment like Pazopanib works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Citrus Bioflavonoid should be avoided for Desmoid Tumor along with treatment Pazopanib. Citrus Bioflavonoid impacts pathways WNT Beta-catenin Signaling which either promote drivers of the disease and/or nullify the treatment effect. Additionally, Citrus Bioflavonoids contain key ingredients like Obacunone which have CYP3A4 interactions with Pazopanib treatment, and hence should be avoided by cancer patients undergoing this treatment. (Fan, Y. et al,Chinese Herbal Medicines, 9(3), 295–298, 2017; Caroline F Thorn et al, Pharmacogenet Genomics.,2017) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Citrus Bioflavonoid Supplements benefit Diffuse Large B-Cell Lymphoma (Relapsed Refractory DLBCL) Cancer Patients undergoing Prednisone Treatment?
Diffuse Large B-Cell Lymphoma (Relapsed Refractory DLBCL) is characterized and driven by specific genetic mutations like CREBBP and KMT2D leading to biochemical pathway changes in MAPK Signaling, NFKB Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling and MYC Signaling. A cancer treatment like Prednisone works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Citrus Bioflavonoid supplement should be considered for Diffuse Large B-Cell Lymphoma (Relapsed Refractory DLBCL) along with treatment Prednisone. Citrus Bioflavonoid supplement impacts pathways MAPK Signaling and NFKB Signaling which either obstruct drivers of the disease (DLBCL) and/or improve the treatment effect.
3. Are Citrus Bioflavonoid Supplements Safe for Healthy Individuals with CDH1 Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. CDH1 is one of the genes generally available in panels for cancer risk testing.
CDH1 mutation causes biochemical pathways WNT Beta-catenin Signaling, Adherens junction, Epithelial to Mesenchymal Transition, Growth Factor Signaling and Estrogen Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Citrus Bioflavonoids should be avoided when the genetic panel identifies mutation of CDH1 for Breast Cancer and Gastric Cancer. Citrus Bioflavonoid impacts pathways WNT Beta-catenin Signaling and Adherens junction and creates adverse effects with CDH1 and related conditions.
4. Are Citrus Bioflavonoid Supplements Safe for Healthy Individuals with TP53 Mutation Associated Genetic Risk?
TP53 is one of the genes available in panels for cancer risk testing. TP53 mutation causes biochemical pathways P53 Signaling, MAPK Signaling, Sirtuin Signaling, Growth Factor Signaling and DNA Repair to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Citrus Bioflavonoid supplements when the genetic panel identifies mutation in TP53 for Breast Cancer and Lung Cancer. Citrus Bioflavonoid impacts pathways P53 Signaling and MAPK Signaling and creates a supportive effect in those with TP53 and related conditions.
* Other Factors are also included like Bmi, Lifestyle Habits, Treatments
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Citrus Bioflavonoid, is an effective tool which can be controlled by you, while facing cancer.
“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
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