Nutritional supplements like Chrysin have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Chrysin supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Chrysin supplements can benefit Richter syndrome patients on Prednisone cancer treatment. But avoid Chrysin supplements if on Prednisone cancer treatment for Rosai-Dorfman disease. Similarly, taking nutritional supplement Chrysin can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene CDK4. But avoid taking nutritional supplement Chrysin when at genetic risk of cancer due to mutation of gene BRCA1.
The takeaway being – your individual context will influence your decision if nutritional supplement Chrysin is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Chrysin based on individual context and conditions.
So the question is should you take the supplement Chrysin? Should you take it when at genetic risk of cancer for mutation of gene BRCA1? Should you take it when at genetic risk of cancer for mutation of gene CDK4? Should you take it when diagnosed with Rosai-Dorfman disease? Should you take Chrysin supplement when diagnosed with Richter syndrome? Should you take it when on Prednisone treatment? Should you continue taking it if you change your treatment from Prednisone to Prednisone? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Chrysin.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Rosai-Dorfman disease or Richter syndrome, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Chrysin.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Chrysin? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene BRCA1 the same as due to mutation of gene CDK4? Are the implications of Rosai-Dorfman disease the same as Richter syndrome? Is it one and the same if you are on treatment Prednisone or Prednisone?
Chrysin – A Nutritional Supplement
Chrysin is a flavonoid found in a variety of plants. It is widely used in herbal medicines in Asia. It is considered to have antioxidant, anti-inflammatory and cytotoxic effects. (Saima Naz et al, Life Sci., 2019) Following are some of the purported uses/benefits of Chrysin:
- May help reduce depression
- May help reduce inflammation
- May help normalize blood sugar levels
- May have protective effects on heart, liver and kidneys
- May improve athletic performance
However, chrysin might increase bruising and bleeding in those with bleeding disorders.
Chrysin is an active ingredient found in various food items. Honey, Passion fruit, Cherry, Oyster Mushroom and Carrot contain Chrysin at different concentration levels along with other active ingredients. The molecular pathways which are regulated by Chrysin include MYC Signaling, Cell Cycle, Stem Cell Signaling, Cell Cycle Checkpoints and Apoptosis. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Chrysin individually or in combination is an important decision to be made. When making decisions on the use of supplement Chrysin for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Chrysin use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Chrysin Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Chrysin for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Chrysin may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Chrysin should be avoided or not and why.
1. Will Chrysin Supplements benefit Rosai-Dorfman disease Patients undergoing Prednisone Cancer treatment?
Rosai-Dorfman disease is characterized and driven by specific genetic mutations like KRAS and MAP2K1 leading to biochemical pathway changes in MYC Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling. A cancer treatment like Prednisone works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Chrysin should be avoided for Rosai-Dorfman disease along with treatment Prednisone. Chrysin impacts pathways MYC Signaling which either promote drivers of the disease and/or nullify the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Chrysin Supplements benefit Richter syndrome Patients undergoing Prednisone Cancer Treatment?
Richter syndrome is characterized and driven by specific genetic mutations like MYC and TRAF3 leading to biochemical pathway changes in Cell Cycle, Apoptosis, NFKB Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling. A cancer treatment like Prednisone works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Chrysin supplement should be considered for Richter syndrome along with treatment Prednisone. Chrysin supplement impacts pathways Cell Cycle and Apoptosis which either obstruct drivers of the disease (Richter syndrome) and/or improve the treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Chrysin Supplements Safe for Healthy Individuals with BRCA1 Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. BRCA1 is one of the genes generally available in panels for cancer risk testing.
BRCA1 mutation causes biochemical pathways Stem Cell Signaling, Estrogen Signaling, P53 Signaling, Angiogenesis and Growth Factor Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Chrysin should be avoided when the genetic panel identifies mutation of BRCA1 for Breast Cancer and Ovarian Cancer. Chrysin impacts pathways Stem Cell Signaling and Estrogen Signaling and creates adverse effects with BRCA1 and related conditions.
4. Are Chrysin Supplements Safe for Healthy Individuals with CDK4 Mutation Associated Genetic Risk?
CDK4 is one of the genes available in panels for cancer risk testing. CDK4 mutation causes biochemical pathways Cell Cycle Checkpoints, Cell Cycle, Growth Factor Signaling, DNA Repair and MAPK Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Chrysin supplements when the genetic panel identifies mutation in CDK4 for Skin Cancer. Chrysin impacts pathways/processes like Cell Cycle Checkpoints and Cell Cycle and creates a supportive effect in those with CDK4 and related conditions.
* Other Factors are also included like BMI, Lifestyle Habits, Treatments
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Chrysin, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Foods to Eat After Cancer Diagnosis!
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.