Nutritional supplements like Chitrak have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Chitrak supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Chitrak supplements can benefit Bladder Urothelial Carcinoma patients on Vinblastine cancer treatment. But avoid Chitrak supplements if on Prednisone treatment for Rosai-Dorfman disease. Similarly, taking nutritional supplement Chitrak can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene TERT. But avoid taking nutritional supplement Chitrak when at genetic risk of cancer due to mutation of the gene SMAD4.
The takeaway being – your individual context will influence your decision if nutritional supplement Chitrak is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Chitrak based on individual context and conditions.
So the question is should you take the supplement Chitrak? Should you take it when at genetic risk of cancer for mutation of the gene SMAD4? Should you take it when at genetic risk of cancer for mutation of gene TERT? Should you take it when diagnosed with Rosai-Dorfman disease? Should you take Chitrak when diagnosed with Bladder Urothelial Carcinoma? Should you take chitrak supplement when on Prednisone cancer treatment? Should you continue taking it if you change your treatment from Prednisone to Vinblastine? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Chitrak.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Rosai-Dorfman disease or Bladder Urothelial Carcinoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Chitrak.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Chitrak? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene SMAD4 the same as due to mutation of gene TERT? Are the implications of Rosai-Dorfman disease same as Bladder Urothelial Carcinoma? Is it one and the same if you are on treatment Prednisone or Vinblastine?
Chitrak – A Nutritional Supplement
Chitrak or Plumbago zeylanica is a shrub with antioxidant properties which grows in tropical and subtropical climates in places like Australia and India. It is also known as Ceylon leadwort, doctorbush or wild leadwort. It is widely used in Ayurveda for various health conditions due to its antioxidant, antibacterial, anti-inflammatory, antifungal and neuroprotective effects. (Arpita Roy and Navneeta Bharadvaja, Curr Pharm Biotechnol., 2018) Chitrak/Plumbago zeylanica is considered to be a good gastrointestinal flora normaliser. Some of the purported uses/benefits of Chitrak/Plumbago zeylanica includes:
- May help improve digestion problems
- May help reduce pain in muscles and joints
- May help improve cough and cold
- May help improve inflammatory disorders like rheumatoid arthritis
- May help reduce blood sugar levels
- May help improve liver health
- May help remove natural toxins from the body
- May help boost metabolism
Chitrak supplements contain many active ingredients including Plumbagin at different concentration levels. The molecular pathways which are regulated by Chitrak include MAPK Signaling, Cell Survival, Growth Factor Signaling, TGFB Signaling and MYC Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Chitrak/Plumbago zeylanica individually or in combination is an important decision to be made. When making decisions on the use of supplement Chitrak for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Chitrak/Plumbago zeylanica use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Chitrak Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Chitrak for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Chitrak may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Chitrak should be avoided or not and why.
1. Will Chitrak Supplements benefit Rosai-Dorfman disease Patients undergoing Prednisone Cancer treatment?
Rosai-Dorfman disease is characterized and driven by specific genetic mutations like KRAS and MAP2K1 leading to biochemical pathway changes in MAPK Signaling, MYC Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling. A cancer treatment like Prednisone works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Chitrak should be avoided for Rosai-Dorfman disease along with treatment Prednisone. Chitrak impacts pathways like MAPK Signaling and MYC Signaling which either promote drivers of the disease and/or nullify the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Chitrak Supplements benefit Bladder Urothelial Carcinoma/Cancer Patients undergoing Vinblastine Treatment?
Bladder Urothelial Carcinoma is characterized and driven by specific genetic mutations like TP53 and MUC16 leading to biochemical pathway changes in Cell Survival, Microtubule Dynamics, Carbohydrate Metabolism, PI3K-AKT-MTOR Signaling and MAPK Signaling. A cancer treatment like Vinblastine works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Chitrak should be considered for Bladder Urothelial Carcinoma along with treatment Vinblastine. Chitrak impacts pathways/processes like Cell Survival and Microtubule Dynamics which either obstruct drivers of the disease(Bladder Urothelial Carcinoma) and/or improve the treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Chitrak Supplements Safe for Healthy Individuals with SMAD4 Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. SMAD4 is one of the genes generally available in panels for cancer risk testing.
SMAD4 mutation causes biochemical pathways Growth Factor Signaling, MAPK Signaling, Lipid Metabolism, Inflammation and Cell Cycle to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Chitrak should be avoided when the genetic panel identifies mutation of SMAD4 for Colon Cancer and Gastric Cancer. Chitrak impacts pathways like Growth Factor Signaling and MAPK Signaling and creates adverse effects with SMAD4 and related conditions.
4. Are Chitrak Supplements Safe for Healthy Individuals with TERT Mutation Associated Genetic Risk?
TERT is one of the genes available in panels for cancer risk testing. TERT mutation causes biochemical pathways TGFB Signaling, MAPK Signaling, Cytokine Signaling, Hypoxia and RUNX Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Chitrak supplements when the genetic panel identifies mutation in TERT for Hematological Cancer. Chitrak impacts pathways like TGFB Signaling and MAPK Signaling and a supportive effect in those with TERT and related conditions.
* Other Factors are also included like BMI, Lifestyle Habits, Treatments
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Chitrak, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.