Nutritional supplements like Cabbage have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Cabbage supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Cabbage supplements can benefit Rosai-Dorfman disease patients on Methotrexate cancer treatment. But avoid Cabbage supplements if on Ifosfamide cancer treatment for Testicular Germ Cell Tumors. Similarly, taking nutritional supplement Cabbage can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene KIT. But avoid taking nutritional supplement Cabbage when at genetic risk of cancer due to mutation of gene MRE11.
The takeaway being – your individual context will influence your decision if nutritional supplement Cabbage is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Cabbage based on individual context and conditions.
So the question is should you take supplement Cabbage? Should you take it when at genetic risk of cancer for mutation of gene MRE11? Should you take it when at genetic risk of cancer for mutation of gene KIT? Should you take it when diagnosed with Testicular Germ Cell Tumors? Should you take Cabbage supplements when diagnosed with Rosai-Dorfman disease? Should you take Cabbage supplement when on Ifosfamide cancer treatment? Should you continue taking Cabbage supplement if you change your cancer treatment from Ifosfamide to Methotrexate? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Cabbage.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Testicular Germ Cell Tumor or Rosai Dorfman disease, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Cabbage.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Cabbage? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene MRE11 the same as due to mutation of gene KIT? Are the implications of Testicular Germ Cell Tumors same as Rosai-Dorfman disease? Is it one and the same if you are on treatment with Ifosfamide or Methotrexate?
Cabbage – A Nutritional Supplement
Cabbage is a green leafy vegetable that belongs to the cruciferous family of vegetables which includes other vegetables like kale, broccoli, cauliflower, Brussels sprouts, bok choy, and turnips. Cabbage is highly nutritious and is known to have many health benefits. Following are some of the general health benefits of cabbage/cabbage supplements:
- May improve heart health
- May help reduce inflammation
- May reduce blood pressure
- May help reduce bad cholesterol levels
- May help improve digestion and prevent constipation
- May help improve immunity
Cabbage is also available in the form of dietary nutritional supplements.
Cabbage supplements contain many active ingredients including Benzyl Isothiocyanate, Brassinin, Indole-3-carbinol, Vitamin C, Quercetin, Sulforaphane and Crocetin at different concentration levels. The molecular pathways which are regulated by Cabbage include Cell Cycle, RAS-RAF Signaling, DNA Repair, Oxidative Stress and MAPK Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Cabbage individually or in combination is an important decision to be made. When making decisions on the use of supplement Cabbage for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Cabbage use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Cabbage Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Cabbage for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Cabbage may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Cabbage should be avoided or not and why.
1. Will Cabbage Supplements benefit Testicular Germ Cell Tumor/Cancer Patients undergoing Ifosfamide treatment?
Testicular Germ Cell Tumors is characterized and driven by specific genetic mutations like KIT and KRAS leading to biochemical pathway changes in Cell Cycle, Oxidative Stress, DNA Repair, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling. A cancer treatment like Ifosfamide works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Cabbage should be avoided for Testicular Germ Cell Tumors along with the treatment Ifosfamide. Cabbage impacts pathways Cell Cycle and Oxidative Stress which either promote drivers of the disease and/or nullify the treatment effect. Additionally, Cabbage contains key active ingredients like Benzyl Isothiocyanate which have CYP3A4 and CYP2A6 (drug metabolizing enzymes) interactions with Ifosfamide treatment, and hence should be avoided by cancer patients undergoing this treatment. (Pius S Fasinu et al, Front Oncol., 2019; Linda B von Weymarn et al, Carcinogenesis., 2006) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Cabbage Supplements benefit Rosai-Dorfman disease Patients undergoing Methotrexate Cancer Treatment?
Rosai-Dorfman disease is characterized and driven by specific genetic mutations like KRAS and MAP2K1 leading to biochemical pathway changes in RAS-RAF Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. A cancer treatment like Methotrexate works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Cabbage supplements should be considered for Rosai-Dorfman disease along with treatment Methotrexate. Cabbage supplement impacts pathways RAS-RAF Signaling and MAPK Signaling which either obstruct drivers of the Rosai-Dorfman disease and/or improve the treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Cabbage Supplements Safe for Healthy Individuals with MRE11 Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. MRE11 is one of the genes generally available in panels for cancer risk testing.
MRE11 mutation causes biochemical pathways DNA Repair, Estrogen Signaling, Stem Cell Signaling, Angiogenesis and Growth Factor Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Cabbage should be avoided when the genetic panel identifies the mutation of MRE11 for Breast Cancer. Cabbage impacts pathways DNA Repair and Estrogen Signaling and creates adverse effects with MRE11 and related conditions.
4. Are Cabbage Supplements Safe for Healthy Individuals with KIT Mutation Associated Genetic Risk?
KIT is one of the genes available in panels for cancer risk testing. KIT mutation causes biochemical pathways RAS-RAF Signaling, Hypoxia, Cancer Epigenetics, PI3K-AKT-MTOR Signaling and Stem Cell Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Cabbage when the genetic panel identifies mutation in KIT for Gastric Cancer and Hematological Cancer. Cabbage impacts pathways RAS-RAF Signaling and Hypoxia and creates a supportive effect in those with KIT and related conditions.
* Other Factors are also included like BMI, Lifestyle Habits, Treatments
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Cabbage, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.