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What should I Eat?

is the most common question asked by cancer patients.
Choose food and nutritional supplements which avoids bad interactions with your cancer treatment and is good for you.

is the most common question asked by cancer patients. Choose food and nutritional supplements which avoids bad interactions with your cancer treatment and is good for you.

Start Personalized Nutrition Planning for  and answer these questions.

Start Personalized Nutrition Planning for and answer these questions.

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For Which Cancer Types Should I Avoid Boneset Supplement?

May 18, 2021

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Highlights 

Nutritional supplements like Boneset have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Boneset supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.

Taking nutritional Boneset supplements can benefit Hodgkin Lymphoma cancer patients on Doxorubicin treatment. But avoid Boneset supplements if on Fluorouracil treatment for Primary Central Nervous System Lymphoma. Similarly, taking nutritional supplement Boneset can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene TP53. But avoid taking nutritional supplement Boneset when at genetic risk of cancer due to mutation of gene CDC73.

The takeaway being – your individual context will influence your decision if nutritional supplement Boneset is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.



Brief Overview

Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements  are high concentrations of active ingredients which are also found in different foods. Difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose  the right combination of supplements like Boneset based on individual context and conditions. 

Boneset Supplements for Cancer Treatment and genetic Risk

So the question is should you take the supplement Boneset? Should you take it when at genetic risk of cancer for mutation of gene CDC73? Should you take it when at genetic risk of cancer for mutation of gene TP53? Should you take it when diagnosed with Primary Central Nervous System Lymphoma? Should you take Boneset supplement when diagnosed with Hodgkin Lymphoma? Should you take it when on Fluorouracil treatment? Should you continue taking it if you change your treatment from Fluorouracil to Doxorubicin? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Boneset.

Cancer 

Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Primary Central Nervous System Lymphoma or Hodgkin Lymphoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Boneset.

So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Boneset? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene CDC73 the same as due to mutation of gene TP53? Are the implications of Primary Central Nervous System Lymphoma same as Hodgkin Lymphoma? Is it one and the same if you are on treatment Fluorouracil or Doxorubicin?

Boneset – A Nutritional Supplement

Boneset is a plant which is commonly found in the damp areas in North America. The dried leaves and flowers of this plant are considered to have medicinal properties. Boneset has anti-inflammatory properties and has been used as a herbal remedy for various health conditions. (Mareike Maas et al, J Ethnopharmacol., 2011) Some of the purported uses/benefits of boneset supplements include its use to reduce fever, common cold and symptoms associated with lung infections.

Boneset supplements contain many active ingredients including Eupatorin at different concentration levels. The molecular pathways which are regulated by Boneset include NFKB Signaling, Apoptosis, WNT Beta-catenin Signaling and Angiogenesis. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Boneset individually or in combination is an important decision to be made. When making decisions on the use of supplement Boneset for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Boneset use cannot be a one-size-fits-all decision for all types of cancers.

Choosing Boneset Supplements for Your Cancer

The reason there is no easy way to answer the question “When should I avoid Boneset for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Boneset may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Boneset should be avoided or not and why.

1. Will Boneset Supplements benefit Primary Central Nervous System Lymphoma Cancer Patients undergoing Fluorouracil treatment?

Primary Central Nervous System Lymphoma is characterized and driven by specific genetic mutations like MYD88 and CD79B leading to biochemical pathway changes in NFKB Signaling, B Cell Receptor Signaling and RAS-RAF Signaling. A cancer treatment like Fluorouracil works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Boneset should be avoided for Primary Central Nervous System Lymphoma along with treatment Fluorouracil. Boneset impacts pathways like NFKB Signaling which either promote drivers of the disease and/or nullify the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).

2. Will Boneset Supplements benefit Hodgkin Lymphoma Cancer Patients undergoing Doxorubicin Treatment?

Hodgkin Lymphoma is characterized and driven by specific genetic mutations like TP53 and B2M leading to biochemical pathway changes in Apoptosis, WNT Beta-catenin Signaling, P53 Signaling, MYC Signaling and Cell Cycle Checkpoints. A cancer treatment like Doxorubicin works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Boneset supplement should be considered for Hodgkin Lymphoma along with treatment Doxorubicin. Boneset impacts pathways like Apoptosis and WNT Beta-catenin Signaling which either obstruct drivers of the disease and/or improve the treatment effect.

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3. Are Boneset Supplements Safe for Healthy Individuals with CDC73 Mutation Associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. CDC73 is one of the genes generally available in panels for cancer risk testing.

CDC73 mutation causes biochemical pathways WNT Beta-catenin Signaling, Angiogenesis and Stem Cell Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Boneset should be avoided when the genetic panel identifies mutation of CDC73 for Neuroendocrine Cancer. Boneset impacts pathways like WNT Beta-catenin Signaling and Angiogenesis and creates adverse effects with CDC73 and related conditions.

4. Are Boneset Supplements Safe for Healthy Individuals with TP53 Mutation Associated Genetic Risk?

TP53 is one of the genes available in panels for cancer risk testing. TP53 mutation causes biochemical pathways Apoptosis, Angiogenesis, DNA Repair, Cancer Epigenetics and PI3K-AKT-MTOR Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Boneset supplements when the genetic panel identifies mutation in TP53 for Breast Cancer and Lung Cancer. Boneset impacts pathways like Apoptosis and Angiogenesis and creates a supportive effect in those with TP53 and related conditions.

Which Cancer Types to Avoid Boneset Supplement

* Other Factors are also included like BMI, Lifestyle Habits, Treatments

In Conclusion 

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Boneset, is an effective tool which can be controlled by you, while facing cancer.

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

Get started NOW with answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.