addonfinal2

What should I Eat?

is the most common question asked by cancer patients.
Choose food and nutritional supplements which avoids bad interactions with your cancer treatment and is good for you.

is the most common question asked by cancer patients. Choose food and nutritional supplements which avoids bad interactions with your cancer treatment and is good for you.

Start Personalized Nutrition Planning for  and answer these questions.

Start Personalized Nutrition Planning for and answer these questions.

0
(0)

For Which Cancer Types Should I Avoid Ashitaba Supplement?

May 18, 2021

Home » Blogs » For Which Cancer Types Should I Avoid Ashitaba Supplement?
You can also read this in

Highlights

Nutritional supplements like Ashitaba have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Ashitaba supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.

Taking nutritional Ashitaba supplements can benefit Rhabdomyosarcoma cancer patients on Radiation treatment. But avoid Ashitaba supplements if on Lanreotide treatment for Pancreatic Neuroendocrine Tumor. Similarly, taking nutritional supplement Ashitaba can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene APC. But avoid taking nutritional supplement Ashitaba when at genetic risk of cancer due to mutation of gene TSC1.

The takeaway being – your individual context will influence your decision if nutritional supplement Ashitaba is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.



Brief Overview

Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements  are high concentrations of active ingredients which are also found in different foods. Difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose  the right combination of supplements like Ashitaba based on individual context and conditions.

Ashitaba Supplements for Cancer Treatment and genetic Risk

So the question is should you take the supplement Ashitaba? Should you take it when at genetic risk of cancer for mutation of gene TSC1? Should you take it when at genetic risk of cancer for mutation of gene APC? Should you take it when diagnosed with Pancreatic Neuroendocrine Tumor? Should you take Ashitaba supplements when diagnosed with Rhabdomyosarcoma? Should you take it when on Lanreotide treatment? Should you continue taking it if you change your treatment from Lanreotide to Radiation? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Ashitaba.

Cancer

Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available.  After diagnosis with cancer such as Pancreatic Neuroendocrine Tumor or Rhabdomyosarcoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Ashitaba.  

So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Ashitaba? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene TSC1 the same as due to mutation of gene APC? Are the implications of Pancreatic Neuroendocrine Tumor the same as Rhabdomyosarcoma? Is it one and the same if you are on treatment with Lanreotide or Radiation?

Ashitaba – A Nutritional Supplement

Ashitaba, also known as Angelica keiskei, is a herb that mostly grows in Japan. Ashitaba is considered to have antidiabetic, antioxidative, anti-inflammatory, antihypertensive, and antimicrobial properties. (Lindsay K Caesar et al, Planta Med., 2016) Their roots, leaves, and stems are consumed for their medicinal properties. Following are some of the purported uses/benefits of Ashitaba:

  • May help reduce heartburn
  • May help reduce blood pressure
  • May help reduce constipation

Ashitaba supplements contain many active ingredients including Isobavachalcone at different concentration levels. The molecular pathways which are regulated by Ashitaba include PI3K-AKT-MTOR Signaling, RAS-RAF Signaling, Autophagy, Lipid Metabolism and Angiogenesis. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Ashitaba individually or in combination is an important decision to be made. When making decisions on the use of supplement Ashitaba for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Ashitaba use cannot be a one-size-fits-all decision for all types of cancers.

Choosing Ashitaba Supplements for Your Cancer 

The reason there is no easy way to answer the question “When should I avoid Ashitaba for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Ashitaba may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Ashitaba should be avoided or not and why. 

1. Will Ashitaba Supplements benefit Pancreatic Neuroendocrine Tumor Patients undergoing Lanreotide treatment?  

Pancreatic Neuroendocrine Tumor is characterized and driven by specific genetic mutations like MEN1 and DAXX leading to biochemical pathway changes in PI3K-AKT-MTOR Signaling, Cancer Epigenetics, Cell Cycle and DNA Repair. A cancer treatment like Lanreotide works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Ashitaba should be avoided for Pancreatic Neuroendocrine Tumor along with treatment Lanreotide. Ashitaba impacts pathways like PI3K-AKT-MTOR Signaling which either promote drivers of the disease and/or nullify the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).

2. Will Ashitaba Supplements benefit Rhabdomyosarcoma Cancer Patients undergoing Radiation Treatment?

Rhabdomyosarcoma is characterized and driven by specific genetic mutations like NRAS and FGFR4 leading to biochemical pathway changes in RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, Epithelial to Mesenchymal Transition and MAPK Signaling. A cancer treatment like Radiation works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Ashitaba supplements should be considered for Rhabdomyosarcoma along with treatment Radiation. Ashitaba supplements impact pathways RAS-RAF Signaling and PI3K-AKT-MTOR Signaling which either obstruct drivers of the disease (Rhabdomyosarcoma) and/or improve the treatment effect.

What is Personalized Nutrition for Cancer? | What foods/supplements are recommended?

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.

3. Are Ashitaba Supplements Safe for Healthy Individuals with TSC1 Mutation Associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. TSC1 is one of the genes generally available in panels for cancer risk testing.

TSC1 mutation causes biochemical pathways Autophagy, PI3K-AKT-MTOR Signaling, Endoplasmic Reticulum Stress, Stem Cell Signaling and Angiogenesis to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Ashitaba should be avoided when the genetic panel identifies mutation of TSC1 for Kidney Cancer. Ashitaba impacts pathways like Autophagy and PI3K-AKT-MTOR Signaling and creates adverse effects with TSC1 and related conditions.

4. Are Ashitaba Supplements Safe for Healthy Individuals with APC Mutation Associated Genetic Risk? 

APC is one of the genes available in panels for cancer risk testing. APC mutation causes biochemical pathways Lipid Metabolism, WNT Beta-catenin Signaling, Stem Cell Signaling, Angiogenesis and Growth Factor Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Ashitaba supplements when the genetic panel identifies mutation in APC for Colon Cancer. Ashitaba impacts pathways like Lipid Metabolism and WNT Beta-catenin Signaling and creates a supportive effect in those with APC and related conditions.

Which Cancer Types to Avoid Ashitaba Supplement

* Other Factors are also included like BMI, Lifestyle Habits, Treatments

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Ashitaba, is an effective tool which can be controlled by you, while facing cancer.

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

Get started NOW with answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


How useful was this post?

Click on a star to rate it!

Average rating 0 / 5. Vote count: 0

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?