Nutritional supplements like Cassia Fistula have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Cassia Fistula supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Cassia Fistula supplements can benefit Mycosis fungoides patients on Romidepsin cancer treatment. But avoid Cassia Fistula supplements if on Lenalidomide treatment for Myelodysplastic Syndrome. Similarly, taking nutritional supplement Cassia Fistula can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene MAX. But avoid taking nutritional supplement Cassia Fistula when at genetic risk of cancer due to mutation of gene MRE11.
The takeaway being – your individual context will influence your decision if nutritional supplement Cassia Fistula is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods.The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Cassia Fistula based on individual context and conditions.
So the question is should you take the supplement Cassia Fistula? Should you take it when at genetic risk of cancer for mutation of gene MRE11? Should you take it when at genetic risk of cancer for mutation of gene MAX? Should you take it when diagnosed with Myelodysplastic Syndrome? Should you take Cassia Fistula supplement when diagnosed with Mycosis fungoides? Should you take it when on Lenalidomide treatment? Should you continue taking it if you change your treatment from Lenalidomide to Romidepsin? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Cassia Fistula.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Myelodysplastic Syndrome or Mycosis fungoides, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Cassia Fistula.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Cassia Fistula? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene MRE11 the same as due to mutation of gene MAX? Are the implications of Myelodysplastic Syndrome same as Mycosis fungoides? Is it one and the same if you are on treatment with Lenalidomide or Romidepsin?
Cassia Fistula – A Nutritional Supplement
Cassia fistula, a flowering plant with golden yellow flowers, is considered to have medicinal properties due to its antioxidant and anti-inflammatory properties. It is also known as golden shower, purging cassia, Indian laburnum, or pudding-pipe tree. It is commonly seen in India and Southeast Asia and has been widely used in traditional medicines including Ayurveda, Unani and Chinese for various health conditions.(Arshad H Rahmani, Pharmacognosy Res., Jul-Sep 2015)
Cassia Fistula supplements contain many active ingredients including Sennoside B at different concentration levels. The molecular pathways which are regulated by Cassia Fistula include Cancer Epigenetics, RAS-RAF Signaling, DNA Repair, Cell Cycle and Amino Acid Metabolism. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Cassia Fistula individually or in combination is an important decision to be made. When making decisions on the use of supplement Cassia Fistula for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Cassia Fistula use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Cassia Fistula Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Cassia Fistula for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Cassia Fistula may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Cassia Fistula should be avoided or not and why.
1. Will Cassia Fistula Supplements benefit Myelodysplastic Syndrome Patients undergoing Lenalidomide Cancer treatment?
Myelodysplastic Syndrome is characterized and driven by specific genetic mutations like ASXL1 and TET2 leading to biochemical pathway changes in Cancer Epigenetics, mRNA Splicing and MYC Signaling. A cancer treatment like Lenalidomide works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Cassia Fistula should be avoided for Myelodysplastic Syndrome along with treatment Lenalidomide. Cassia Fistula impacts pathways/processes like Cancer Epigenetics which either promote drivers of the disease and/or nullify the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Cassia Fistula Supplements benefit Mycosis fungoides Patients undergoing Romidepsin Cancer Treatment?
Mycosis fungoides is characterized and driven by specific genetic mutations like FAT1 and MGAM leading to biochemical pathway changes in RAS-RAF Signaling, Amino Acid Metabolism, DNA Repair, PI3K-AKT-MTOR Signaling and MAPK Signaling. A cancer treatment like Romidepsin works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Cassia Fistula supplement should be considered for Mycosis fungoides along with treatment Romidepsin. Cassia Fistula supplement impacts pathways like RAS-RAF Signaling and Amino Acid Metabolism which either obstruct drivers of the disease (Mycosis fungoides) and/or improve the treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Cassia Fistula Supplements Safe for Healthy Individuals with MRE11 Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. MRE11 is one of the genes generally available in panels for cancer risk testing.
MRE11 mutation causes biochemical pathways DNA Repair, Stem Cell Signaling, Angiogenesis, Growth Factor Signaling and Estrogen Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Cassia Fistula should be avoided when the genetic panel identifies mutation of MRE11 for Breast Cancer. Cassia Fistula impacts pathways/processes like DNA Repair and Stem Cell Signaling and creates adverse effects with MRE11 and related conditions.
4. Are Cassia Fistula Supplements Safe for Healthy Individuals with MAX Mutation Associated Genetic Risk?
MAX is one of the genes available in panels for cancer risk testing. MAX mutation causes biochemical pathways Cell Cycle, MAPK Signaling, Cancer Epigenetics, Stem Cell Signaling and Angiogenesis to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Cassia Fistula supplements when the genetic panel identifies mutation in MAX for Neuroendocrine Cancer. Cassia Fistula impacts the pathways like Cell Cycle and MAPK Signaling and creates a supportive effect in those with MAX and related conditions.
* Other Factors are also included like BMI, Lifestyle Habits, Treatments
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Cassia Fistula, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.