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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Primary Central Nervous System Lymphoma!

Jul 28, 2023

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Introduction

Foods for Primary Central Nervous System Lymphoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Primary central nervous system lymphoma (PCNSL) is a type of non-Hodgkin lymphoma that specifically affects the central nervous system. Accurate diagnosis and determining the prognosis of PCNSL are essential for developing a treatment plan. The survival rate for PCNSL varies depending on various factors, such as the stage and subtype of the lymphoma. The appropriate ICD-10 code ensures proper medical coding and documentation. PCNSL is different from systemic lymphomas as it primarily involves the central nervous system. Various imaging techniques, such as magnetic resonance imaging (MRI), play a crucial role in diagnosing PCNSL and identifying its characteristics. HIV infection can predispose individuals to PCNSL. The diagnosis of PCNSL requires a comprehensive evaluation, including a biopsy and histopathological analysis. The National Comprehensive Cancer Network (NCCN) provides guidelines for the management of PCNSL. Imaging features of PCNSL can be observed in radiological studies. Understanding the epidemiology and clinical presentation of PCNSL is essential for early detection and appropriate management. By staying informed and working closely with healthcare professionals, individuals with PCNSL can improve their overall outcomes and receive appropriate treatment.



For Primary Central Nervous System Lymphoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Primary Central Nervous System Lymphoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Primary Central Nervous System Lymphoma?

For example does it matter if vegetable Common Mushroom is consumed more compared to Swede? Does it make any difference if fruit Pummelo is preferred over European Cranberry? Also if similar choices are made for nuts/seeds like Butternut over Cashew Nut and for pulses like Broad Bean over Lentils. And if what I eat matters – then how does one identify foods which are recommended for Primary Central Nervous System Lymphoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Primary Central Nervous System Lymphoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Primary Central Nervous System Lymphoma can be characterized by a unique set of biochemical pathways - the signature pathways of Primary Central Nervous System Lymphoma. Biochemical pathways like Apoptosis, MAPK Signaling, NFKB Signaling, Focal Adhesion are part of the signature definition of Primary Central Nervous System Lymphoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Apigenin, Curcumin, Quercetin, Lycopene, Naringin. And European Cranberry contains active ingredients Apigenin, Curcumin, Quercetin, Lycopene, Ellagic Acid and possibly others.

A common mistake made when deciding and choosing foods to eat for Primary Central Nervous System Lymphoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Primary Central Nervous System Lymphoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Primary Central Nervous System Lymphoma?

Personalized nutrition for cancers like Primary Central Nervous System Lymphoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Primary Central Nervous System Lymphoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Primary Central Nervous System Lymphoma

All cancers like Primary Central Nervous System Lymphoma can be characterized by a unique set of biochemical pathways – the signature pathways of Primary Central Nervous System Lymphoma. Biochemical pathways like Apoptosis, MAPK Signaling, NFKB Signaling, Focal Adhesion are part of the signature definition of Primary Central Nervous System Lymphoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Primary Central Nervous System Lymphoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Primary Central Nervous System Lymphoma when taking cancer treatment Epirubicin, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

MYD88, PIM1, CD79B, FAT4 and TCL1A are the top ranked reported genes for Primary Central Nervous System Lymphoma. MYD88 is reported in 70.0 % of the representative patients across all clinical trials. And PIM1 is reported in 40.0 %. The combined population patient data cover ages from 54 to 83. 44.4 % of the patient data are identified as men. The Primary Central Nervous System Lymphoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Primary Central Nervous System Lymphoma!

Food and Supplements for Primary Central Nervous System Lymphoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable COMMON MUSHROOM or SWEDE?

Vegetable Common Mushroom contains many active ingredients or bioactives such as Apigenin, Curcumin, Luteolin, Daidzein, Phloretin. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle, MAPK Signaling and Cell Survival and others. Common Mushroom is recommended for Primary Central Nervous System Lymphoma when ongoing cancer treatment is Epirubicin. This is because Common Mushroom modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Epirubicin.

Some of the active ingredients or bioactives in vegetable Swede are Apigenin, Curcumin, Daidzein, Phloretin, Cinnamaldehyde. These active ingredients manipulate various biochemical pathways like DNA Repair and Oxidative Stress and others. Swede is not recommended for Primary Central Nervous System Lymphoma when ongoing cancer treatment is Epirubicin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE COMMON MUSHROOM IS RECOMMENDED OVER SWEDE FOR Primary Central Nervous System Lymphoma AND TREATMENT Epirubicin.

Choose Fruit EUROPEAN CRANBERRY or PUMMELO?

Fruit European Cranberry contains many active ingredients or bioactives such as Apigenin, Curcumin, Quercetin, Lycopene, Ellagic Acid. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle, MAPK Signaling and Cell Survival and others. European Cranberry is recommended for Primary Central Nervous System Lymphoma when ongoing cancer treatment is Epirubicin. This is because European Cranberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Epirubicin.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Quercetin, Lycopene, Naringin. These active ingredients manipulate various biochemical pathways like DNA Repair and Glutathione Metabolism and others. Pummelo is not recommended for Primary Central Nervous System Lymphoma when ongoing cancer treatment is Epirubicin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT EUROPEAN CRANBERRY IS RECOMMENDED OVER PUMMELO FOR Primary Central Nervous System Lymphoma AND TREATMENT Epirubicin.

Choose Nut BUTTERNUT or CASHEW NUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Lycopene, Luteolin, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle, MAPK Signaling and Cell Survival and others. Butternut is recommended for Primary Central Nervous System Lymphoma when ongoing cancer treatment is Epirubicin. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Epirubicin.

Some of the active ingredients or bioactives in Cashew Nut are Curcumin, Quercetin, Daidzein, Phloretin, Cinnamaldehyde. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Oxidative Stress and MYC Signaling and others. Cashew Nut is not recommended for Primary Central Nervous System Lymphoma when ongoing cancer treatment is Epirubicin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER CASHEW NUT FOR Primary Central Nervous System Lymphoma AND TREATMENT Epirubicin.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Primary Central Nervous System Lymphoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GARDEN ONION or GROUNDCHERRY?

Vegetable Garden Onion contains many active ingredients or bioactives such as Apigenin, Curcumin, Quercetin, Lycopene, Formononetin. These active ingredients manipulate various biochemical pathways like P53 Signaling, B Cell Receptor Signaling, Cell Cycle Checkpoints and MYC Signaling and others. Garden Onion is recommended for risk of Primary Central Nervous System Lymphoma when associated genetic risk is CD79B. This is because Garden Onion increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Groundcherry are Apigenin, Curcumin, Lycopene, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling and NFKB Signaling and others. Groundcherry is not recommended when risk of Primary Central Nervous System Lymphoma when associated genetic risk is CD79B because it increases the signature pathways of it.

VEGETABLE GARDEN ONION IS RECOMMENDED OVER GROUNDCHERRY FOR CD79B GENETIC RISK OF CANCER.

Choose Fruit BILBERRY or BREADNUT TREE SEED?

Fruit Bilberry contains many active ingredients or bioactives such as Apigenin, Curcumin, Quercetin, Lycopene, Resveratrol. These active ingredients manipulate various biochemical pathways like Apoptosis, P53 Signaling, NFKB Signaling and MYC Signaling and others. Bilberry is recommended for risk of Primary Central Nervous System Lymphoma when associated genetic risk is CD79B. This is because Bilberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Breadnut Tree Seed are Apigenin, Curcumin, Lycopene, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling and NFKB Signaling and others. Breadnut Tree Seed is not recommended when risk of Primary Central Nervous System Lymphoma when associated genetic risk is CD79B because it increases the signature pathways of it.

FRUIT BILBERRY IS RECOMMENDED OVER BREADNUT TREE SEED FOR CD79B GENETIC RISK OF CANCER.

Choose Nut COMMON WALNUT or JAPANESE WALNUT?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Formononetin, Beta-sitosterol, Psoralen. These active ingredients manipulate various biochemical pathways like NFKB Signaling, P53 Signaling, Cell Cycle Checkpoints and MYC Signaling and others. Common Walnut is recommended for risk of Primary Central Nervous System Lymphoma when associated genetic risk is CD79B. This is because Common Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Japanese Walnut are Apigenin, Curcumin, Lycopene, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling and NFKB Signaling and others. Japanese Walnut is not recommended when risk of Primary Central Nervous System Lymphoma when associated genetic risk is CD79B because it increases the signature pathways of it.

COMMON WALNUT IS RECOMMENDED OVER JAPANESE WALNUT FOR CD79B GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Primary Central Nervous System Lymphoma. Primary Central Nervous System Lymphoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Primary Central Nervous System Lymphoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Common Mushroom contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Primary Central Nervous System Lymphoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.