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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

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Which 3 Foods to Avoid for Splenic Marginal Zone Lymphoma (SMZL Cancer)?

Apr 21, 2021

Estimated reading time: 8 minutes
Home » Blogs » Which 3 Foods to Avoid for Splenic Marginal Zone Lymphoma (SMZL Cancer)?

Highlights

No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Splenic Marginal Zone Lymphoma (SMZL Cancer) needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.

Foods like Caraway and Common Pea should be eaten when undergoing Methotrexate treatment for Splenic Marginal Zone Lymphoma (SMZL Cancer). On the other hand, for this cancer, Ajwain should be eaten with treatment of Cytarabine. On the same lines, avoid foods like Common Bean and Grape with treatment of Methotrexate for Splenic Marginal Zone Lymphoma. If the treatment is Cytarabine, then avoid Amaranth and Anise.

Similarly, Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Cytarabine treatment and hence should be avoided. However, Black seed supplements do not have any known CYP interactions with Methotrexate treatment.

You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Splenic Marginal Zone Lymphoma (SMZL Cancer).



What is Splenic Marginal Zone Lymphoma?

Splenic Marginal Zone Lymphoma (SMZL Cancer) is a rare, slow-growing type of B-cell non-Hodgkin’s lymphoma that develops when B cells (the white blood cells that protect from infection) become abnormal. The incidence rate of this cancer is only 0.13 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 69 years of age, however, it can occur in people of any age. It is more commonly found in white males as compared to other ethnic groups.

Splenic Marginal Zone Lymphoma - Symptoms, Treatment, Diet, Foods

SMZL cancer has prevalence of certain genetic changes. Some of the genes such as NOTCH2, KLF2, TP53, and TNFAIP3 are known to have genetic abnormalities in this cancer resulting in a change of function. 

The genetic abnormalities found in this cancer can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment.  In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for SMZL cancer. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Splenic Marginal Zone Lymphoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer may have to be redesigned.

Why Eating Right Matters for Splenic Marginal Zone Lymphoma?

In this cancer type, activation or inhibition of some of the biochemical pathways including MAPK Signaling, DNA Repair, Microtubule Dynamics, Notch Signaling, MYC Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Splenic Marginal Zone Lymphoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.

Example Foods to “Not Eat” and Eat with Methotrexate treatment for Splenic Marginal Zone Lymphoma

The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Splenic Marginal Zone Lymphoma considering only the treatment changes.

Foods to Avoid

Common Bean : Common Bean contains active ingredients such as Apigenin, Oleic Acid, Gamma-linolenic Acid and others. Apigenin interferes with the impact of Methotrexate in SMZL cancer by activating a specific biological process called DNA Repair. Hence, avoid foods like Common Bean with Methotrexate treatment for Splenic Marginal Zone Lymphoma.

Grape : Grape contains active ingredients such as Berberine, Oleic Acid, Resveratrol and others. Berberine interferes with the impact of Methotrexate in SMZL cancer by blocking a specific biological process called DNA Repair. Hence, do not eat Grape with Methotrexate treatment for this cancer.

Foods to Eat

Caraway :  Caraway contains active ingredients like Linalool, Folic Acid, D-limonene. Intake of Linalool along with Methotrexate treatment for Splenic Marginal Zone Lymphoma causes a decrease  in a specific biochemical pathway which is called  MAPK Signaling, and this is a very positive effect. Caraway hence should be eaten with Methotrexate treatment for this cancer.

Common Pea :  Common Pea contains active ingredients like Lupeol, Oleic Acid, Sinapic Acid. Intake of Lupeol along with Methotrexate treatment for Splenic Marginal Zone Lymphoma causes a decrease  in a specific biochemical pathway which is called  MAPK Signaling, and this is a very positive effect.  Common Pea hence should be eaten with Methotrexate treatment for this cancer.

Should I take this Nutritional Supplement for Splenic Marginal Zone Lymphoma?

Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Methotrexate treatment. Black Seed supports the Methotrexate treatment for Splenic Marginal Zone Lymphoma by decreasing the biochemical pathways called MAPK Signaling, MYC Signaling, Notch Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle, Cancer Epigenetics and RAS-RAF Signaling.

Example Foods to “Not Eat” and Eat with Cytarabine treatment for Splenic Marginal Zone Lymphoma

Foods to Avoid

Amaranth : Amaranth contains active ingredients such as Folic Acid, Oleic Acid and Linolenic Acid and others. Folic Acid interferes with the impact of Cytarabine in Splenic Marginal Zone Lymphoma by activating a specific biochemical pathway called MYC Signaling. Hence, do not eat Amaranth with Cytarabine treatment for this cancer.

Anise : Anise contains active ingredients such as Apigenin, Oleic Acid and Bergapten and others. Apigenin interferes with the impact of Cytarabine in Splenic Marginal Zone Lymphoma by activating a specific biochemical pathway called Microtubule Dynamics. Hence, do not eat Anise with Cytarabine treatment for this cancer.

Foods to Eat

Ajwain :  Ajwain contains active ingredients like Chlorogenic Acid, Methoxsalen and Oleic Acid. Intake of Chlorogenic Acid along with Cytarabine treatment for Splenic Marginal Zone Lymphoma causes a decrease  in a specific biochemical pathway which is called NFKB Signaling, and this is a very positive effect. Ajwain hence should be eaten with Cytarabine treatment for this cancer.

Foods to eat and avoid for Splenic Marginal Zone Lymphoma

Should I take this Nutritional Supplement for Splenic Marginal Zone Lymphoma?

Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Cytarabine treatment, and hence should not be used. Black Seed supplement does not show benefit on other biochemical pathways that could improve the Cytarabine treatment efficacy in SMZL cancer. Hence, avoid taking Black seed supplements with Cytarabine treatment for this cancer.

Which 3 Foods to Avoid for Splenic Marginal Zone Lymphoma (SMZL Cancer)?

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

What are the Symptoms of this Cancer?

In the initial stages, most cancers including Splenic Marginal Zone Lymphoma (SMZL Cancer) may not cause any signs or symptoms. However, as the disease progresses, it may start showing symptoms. 

Following are some of the signs and symptoms that may be caused by this cancer.

  • Enlarged spleen
  • Unexplained weight loss 
  • Night sweats
  • Fever

Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Splenic Marginal Zone Lymphoma.

What are the Treatment Options for this Cancer?

The treatment for Splenic Marginal Zone Lymphoma (SMZL Cancer) may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history. The treatment options for this cancer include:

  • Surgical removal of the spleen
  • Radiation
  • Chemotherapy
  • Antiviral therapy (if associated with HCV infection)

As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Splenic Marginal Zone Lymphoma (SMZL Cancer).

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as SMZL cancer.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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