addonfinal2

What should I Eat?

is the most common question asked by cancer patients.
Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

is the most common question asked by cancer patients. Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

Get your personalized nutrition plan for cancer at 

Get your personalized nutrition plan for cancer at

5
(1)

Which 3 Foods to Avoid for Early T Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL)?

Apr 21, 2021

Home » Blogs » Which 3 Foods to Avoid for Early T Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL)?

Highlights

No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Early T Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.

Foods like Apple and Cabbage should be eaten when undergoing Nelarabine treatment for Early T Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL). On the other hand, avoid foods like Chili Pepper and Lard with treatment of Nelarabine for ETP-ALL.

You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Early T Cell Precursor Acute Lymphoblastic Leukemia.



What is Early T Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL)?

Early T Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL), a rare cancer, is an aggressive T-lymphoblastic leukemia subgroup with poor prognosis. The incidence rate of this cancer is only 1.7 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 39 years of age, however, it can occur in people of any age. 

Early T Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) - Symptoms, Treatment, Diet, Foods

Early T Cell Precursor Acute Lymphoblastic Leukemia has prevalence of certain genetic changes. Some of the genes such as CDKN2A, JAK3, NRAS, and RUNX1 are known to have genetic abnormalities in this cancer resulting in a change of function. 

The genetic abnormalities found in Early T Cell Precursor Acute Lymphoblastic Leukemia can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment.  In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Early T Cell Precursor Acute Lymphoblastic Leukemia. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of ETP-ALL genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Early T Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) nutrition may have to be redesigned.

Why Eating Right Matters for Early T Cell Precursor Acute Lymphoblastic Leukemia?

In ETP-ALL, activation or inhibition of some of the biochemical pathways including Cancer Epigenetics, Cell Cycle, RAS-RAF Signaling, MAPK Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of ETP-ALL, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.

Example Foods to “Not Eat” and Eat with Nelarabine treatment for ETP-ALL

The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Early T Cell Precursor Acute Lymphoblastic Leukemia considering only one specific treatment.

Foods to Avoid

Chili Pepper : Chili Pepper contains active ingredients such as Capsaicin, Dihydrocapsaicin, Oleic Acid and others. Capsaicin interferes with the impact of Nelarabine in Early T Cell Precursor Acute Lymphoblastic Leukemia by activating a specific biochemical pathway called MAPK Signaling. Hence, avoid foods like Chili Pepper with Nelarabine treatment for ETP-ALL. (Sophie Malagarie-Cazenave et al, FEBS Lett., 2009; Annalisa Lonetti et al, J Hematol Oncol., 2016; Bruno Fattizzo et al, Front Oncol., 2020; Ashley McEwan et al, Hemasphere., 2020)

Lard : Lard contains active ingredients such as Myristic Acid, Palmitic Acid and others. Myristic Acid interferes with the impact of Nelarabine in Early T Cell Precursor Acute Lymphoblastic Leukemia by activating a specific biochemical pathway called MAPK Signaling. Hence, avoid foods like Lard with Nelarabine treatment for ETP-ALL. (Sungjin Kim et al, J Biol Chem., 2017; Annalisa Lonetti et al, J Hematol Oncol., 2016; Bruno Fattizzo et al, Front Oncol., 2020; Ashley McEwan et al, Hemasphere., 2020)

Foods to Eat

Apple :  Apple contains active ingredients like Fisetin, Caffeic Acid and Cianidanol. Intake of Fisetin along with Nelarabine treatment for Early T Cell Precursor Acute Lymphoblastic Leukemia causes a decrease in a specific biochemical pathway which is called MAPK Signaling, and this is a very positive effect. Apple hence should be eaten with Nelarabine treatment for ETP-ALL. (Ruey-Hwang Chou et al, PLoS One., 2013; Anna Klimaszewska-Wiśniewska et al, Int J Oncol., 2019; Annalisa Lonetti et al, J Hematol Oncol., 2016; Bruno Fattizzo et al, Front Oncol., 2020; Ashley McEwan et al, Hemasphere., 2020)

Cabbage :  Cabbage contains active ingredients like Delphinidin, Isorhamnetin and Vitamin B3. Intake of Delphinidin along with Nelarabine treatment for Early T Cell Precursor Acute Lymphoblastic Leukemia causes a decrease in a specific biochemical pathway which is called  MAPK Signaling, and this is a very positive effect. Cabbage hence should be eaten with Nelarabine treatment for ETP-ALL. (Whasun Lim and Gwonhwa Song; Oncol Lett., 2017; Annalisa Lonetti et al, J Hematol Oncol., 2016; Bruno Fattizzo et al, Front Oncol., 2020; Ashley McEwan et al, Hemasphere., 2020)

Should I take this Nutritional Supplement for ETP-ALL?

Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Nelarabine treatment. Black Seed supports the Nelarabine treatment for ETP-ALL by decreasing the biochemical pathways like MAPK Signaling and PI3K-AKT-MTOR Signaling. (Jiuxia Pang et al, Oncotarget., 2017; Annalisa Lonetti et al, J Hematol Oncol., 2016; Bruno Fattizzo et al, Front Oncol., 2020; Ashley McEwan et al, Hemasphere., 2020)

India to New York for Cancer Treatment | Need for Personalized Nutrition-specific to Cancer

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.

What are the Symptoms of ETP-ALL?

In the initial stages, most cancers including ETP-ALL may not cause any signs or symptoms. However, as the disease progresses, ETP-ALL may start showing symptoms. 

Following are some of the signs and symptoms that may be caused by ETP-ALL.

  • Increase in superficial lymph nodes
  • Fatigue
  • Petechial hemorrhages
  • Nose bleeds
  • Dizziness
  • Chest Pain
  • Cough

Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of ETP-ALL.

What are the Treatment Options for ETP-ALL?

The treatment for ETP-ALL may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. 

The treatment options for ETP-ALL include a combination of many of the following regimens:

  • Chemotherapy
  • Medications like Steroids
  • Cranial Irradiation (in case of metastasis to brain)
  • Targeted Therapy

As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for ETP-ALL.

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as ETP-ALL.

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

Get started NOW with answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


How useful was this post?

Click on a star to rate it!

Average rating 5 / 5. Vote count: 1

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?