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What Foods are Recommended for Cancer?
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Foods for Early T Cell Precursor Acute Lymphoblastic Leukemia!

Aug 4, 2023

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Introduction

Foods for Early T Cell Precursor Acute Lymphoblastic Leukemia should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.



For Early T Cell Precursor Acute Lymphoblastic Leukemia does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Early T Cell Precursor Acute Lymphoblastic Leukemia does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Early T Cell Precursor Acute Lymphoblastic Leukemia?

For example does it matter if vegetable New Zealand Spinach is consumed more compared to Chayote? Does it make any difference if fruit Pitanga is preferred over French Plantain? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Broad Bean over Yellow Wax Bean. And if what I eat matters – then how does one identify foods which are recommended for Early T Cell Precursor Acute Lymphoblastic Leukemia and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Early T Cell Precursor Acute Lymphoblastic Leukemia!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Early T Cell Precursor Acute Lymphoblastic Leukemia can be characterized by a unique set of biochemical pathways - the signature pathways of Early T Cell Precursor Acute Lymphoblastic Leukemia. Biochemical pathways like Apoptosis, RAS-RAF Signaling, JAK-STAT Signaling, Notch Signaling are part of the signature definition of Early T Cell Precursor Acute Lymphoblastic Leukemia.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pitanga contains active ingredients Myricetin, Apigenin, Isoliquiritigenin, Quercetin, Luteolin. And French Plantain contains active ingredients Myricetin, Apigenin, Isoliquiritigenin, Kaempferol, Quercetin and possibly others.

A common mistake made when deciding and choosing foods to eat for Early T Cell Precursor Acute Lymphoblastic Leukemia – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Early T Cell Precursor Acute Lymphoblastic Leukemia.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Early T Cell Precursor Acute Lymphoblastic Leukemia?

Personalized nutrition for cancers like Early T Cell Precursor Acute Lymphoblastic Leukemia consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Early T Cell Precursor Acute Lymphoblastic Leukemia biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Early T Cell Precursor Acute Lymphoblastic Leukemia

All cancers like Early T Cell Precursor Acute Lymphoblastic Leukemia can be characterized by a unique set of biochemical pathways – the signature pathways of Early T Cell Precursor Acute Lymphoblastic Leukemia. Biochemical pathways like Apoptosis, RAS-RAF Signaling, JAK-STAT Signaling, Notch Signaling are part of the signature definition of Early T Cell Precursor Acute Lymphoblastic Leukemia. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Early T Cell Precursor Acute Lymphoblastic Leukemia need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Early T Cell Precursor Acute Lymphoblastic Leukemia when taking cancer treatment Nelarabine, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

NOTCH1, JAK1, CDK12, MMP24 and TCF7L2 are the top ranked reported genes for Early T Cell Precursor Acute Lymphoblastic Leukemia. NOTCH1 is reported in 83.3 % of the representative patients across all clinical trials. And JAK1 is reported in 50.0 %. The combined population patient data cover ages from 3 to 20. 83.3 % of the patient data are identified as men. The Early T Cell Precursor Acute Lymphoblastic Leukemia biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Early T Cell Precursor Acute Lymphoblastic Leukemia!

Food and Supplements for Early T Cell Precursor Acute Lymphoblastic Leukemia

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable NEW ZEALAND SPINACH or CHAYOTE?

Vegetable New Zealand Spinach contains many active ingredients or bioactives such as Myricetin, Apigenin, Isoliquiritigenin, Kaempferol, Quercetin. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling and others. New Zealand Spinach is recommended for Early T Cell Precursor Acute Lymphoblastic Leukemia when ongoing cancer treatment is Nelarabine. This is because New Zealand Spinach modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Nelarabine.

Some of the active ingredients or bioactives in vegetable Chayote are Myricetin, Apigenin, Isoliquiritigenin, Kaempferol, Luteolin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and Suppressive Histone Methylation and others. Chayote is not recommended for Early T Cell Precursor Acute Lymphoblastic Leukemia when ongoing cancer treatment is Nelarabine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE NEW ZEALAND SPINACH IS RECOMMENDED OVER CHAYOTE FOR Early T Cell Precursor Acute Lymphoblastic Leukemia AND TREATMENT Nelarabine.

Choose Fruit FRENCH PLANTAIN or PITANGA?

Fruit French Plantain contains many active ingredients or bioactives such as Myricetin, Apigenin, Isoliquiritigenin, Kaempferol, Quercetin. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling and others. French Plantain is recommended for Early T Cell Precursor Acute Lymphoblastic Leukemia when ongoing cancer treatment is Nelarabine. This is because French Plantain modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Nelarabine.

Some of the active ingredients or bioactives in fruit Pitanga are Myricetin, Apigenin, Isoliquiritigenin, Quercetin, Luteolin. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics, Suppressive Histone Methylation and Apoptosis and others. Pitanga is not recommended for Early T Cell Precursor Acute Lymphoblastic Leukemia when ongoing cancer treatment is Nelarabine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT FRENCH PLANTAIN IS RECOMMENDED OVER PITANGA FOR Early T Cell Precursor Acute Lymphoblastic Leukemia AND TREATMENT Nelarabine.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Myricetin, Apigenin, Isoliquiritigenin, Kaempferol, Luteolin. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling and others. Butternut is recommended for Early T Cell Precursor Acute Lymphoblastic Leukemia when ongoing cancer treatment is Nelarabine. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Nelarabine.

Some of the active ingredients or bioactives in European Chestnut are Myricetin, Apigenin, Isoliquiritigenin, Kaempferol, Quercetin. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics, Noncoding RNA Signaling and Apoptosis and others. European Chestnut is not recommended for Early T Cell Precursor Acute Lymphoblastic Leukemia when ongoing cancer treatment is Nelarabine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Early T Cell Precursor Acute Lymphoblastic Leukemia AND TREATMENT Nelarabine.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Early T Cell Precursor Acute Lymphoblastic Leukemia or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable COMMON MUSHROOM or JUTE?

Vegetable Common Mushroom contains many active ingredients or bioactives such as Curcumin, Apigenin, Formononetin, Lupeol, Eugenol. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling, JAK-STAT Signaling, Inflammation and Apoptosis and others. Common Mushroom is recommended for risk of Early T Cell Precursor Acute Lymphoblastic Leukemia when associated genetic risk is CDK12. This is because Common Mushroom increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Jute are Quercetin, Curcumin, Apigenin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Interferon Signaling and others. Jute is not recommended when risk of Early T Cell Precursor Acute Lymphoblastic Leukemia when associated genetic risk is CDK12 because it increases the signature pathways of it.

VEGETABLE COMMON MUSHROOM IS RECOMMENDED OVER JUTE FOR CDK12 GENETIC RISK OF CANCER.

Choose Fruit RABBITEYE BLUEBERRY or DATE?

Fruit Rabbiteye Blueberry contains many active ingredients or bioactives such as Quercetin, Eugenol, Linalool, Ferulic Acid, Epicatechin. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling, Apoptosis and MYC Signaling and others. Rabbiteye Blueberry is recommended for risk of Early T Cell Precursor Acute Lymphoblastic Leukemia when associated genetic risk is CDK12. This is because Rabbiteye Blueberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Date are Curcumin, Apigenin, Formononetin, Lupeol, Eugenol. These active ingredients manipulate various biochemical pathways like IL10 Signaling and Interferon Signaling and others. Date is not recommended when risk of Early T Cell Precursor Acute Lymphoblastic Leukemia when associated genetic risk is CDK12 because it increases the signature pathways of it.

FRUIT RABBITEYE BLUEBERRY IS RECOMMENDED OVER DATE FOR CDK12 GENETIC RISK OF CANCER.

Choose Nut PUMPKIN SEEDS or MACADAMIA NUT?

Pumpkin Seeds contains many active ingredients or bioactives such as Cucurbitacin I, Stigmasterol, Beta-sitosterol, Linolenic Acid, Salicylic Acid. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling, JAK-STAT Signaling, Notch Signaling and IL10 Signaling and others. Pumpkin Seeds is recommended for risk of Early T Cell Precursor Acute Lymphoblastic Leukemia when associated genetic risk is CDK12. This is because Pumpkin Seeds increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Macadamia Nut are Curcumin, Apigenin, Formononetin, Lupeol, Eugenol. These active ingredients manipulate various biochemical pathways like Interferon Signaling and MYC Signaling and others. Macadamia Nut is not recommended when risk of Early T Cell Precursor Acute Lymphoblastic Leukemia when associated genetic risk is CDK12 because it increases the signature pathways of it.

PUMPKIN SEEDS IS RECOMMENDED OVER MACADAMIA NUT FOR CDK12 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Early T Cell Precursor Acute Lymphoblastic Leukemia. Early T Cell Precursor Acute Lymphoblastic Leukemia patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Early T Cell Precursor Acute Lymphoblastic Leukemia, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like New Zealand Spinach contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Early T Cell Precursor Acute Lymphoblastic Leukemia?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.