No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Primary Central Nervous System Lymphoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Alfalfa and Apple should be eaten when undergoing Fluorouracil treatment for Primary CNS Lymphoma. On the same lines, avoid foods like Amaranth and Black Tea with treatment of Fluorouracil for Primary CNS Lymphoma. Also, Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Fluorouracil treatment and hence should be avoided.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Primary CNS Lymphoma.
What is Primary Central Nervous System Lymphoma?
Primary Central Nervous System Lymphoma (Primary CNS Lymphoma) is a rare cancer that starts in the lymph tissues of the brain or spinal cord (central nervous system). The incidence rate of this cancer is only 0.6 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 60 years of age, however, it can occur in people of any age. It is more commonly found in men as compared to women.
Primary Central Nervous System Lymphoma has prevalence of certain genetic changes. Some of the genes such as MYD88, CD79B, BTG2, and CARD11 are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Primary CNS Lymphoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Primary CNS Lymphoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Primary CNS Lymphoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer may have to be redesigned.
Why Eating Right Matters for Primary Central Nervous System Lymphoma?
In Primary CNS Lymphoma, activation or inhibition of some of the biochemical pathways including Apoptosis, B Cell Receptor Signaling, Cell Survival, NFKB Signaling and RAS-RAF Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Primary CNS Lymphoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Fluorouracil treatment for Primary Central Nervous System Lymphoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Primary Central Nervous System Lymphoma considering only one specific treatment.
Foods to Avoid with Fluorouracil treatment
Amaranth : Amaranth contains active ingredients such as Isoquercitrin, Folic Acid, Oleic Acid and others. Isoquercitrin interferes with the impact of Fluorouracil in Primary CNS Lymphoma by activating a specific biochemical pathway called NFKB Signaling. Hence, avoid foods like Amaranth with Fluorouracil treatment for Primary CNS Lymphoma.
Black Tea : Black Tea contains active ingredients such as Enoxolone, Theaflavin, 3-hydroxyflavone and others. Enoxolone interferes with the impact of Fluorouracil in Primary CNS Lymphoma by activating a specific biochemical pathway called NFKB Signaling. Hence, do not eat Black Tea with Fluorouracil treatment for Primary Central Nervous System Lymphoma.
Foods to Eat with Fluorouracil treatment
Alfalfa : Alfalfa contains active ingredients like Genistein, Oleic Acid, Linolenic Acid. Intake of Genistein along with Fluorouracil treatment for Primary CNS Lymphoma causes a decrease in a specific biochemical pathway which is called NFKB Signaling, and this is a very positive effect. Alfalfa hence should be eaten with Fluorouracil treatment for Primary Central Nervous System Lymphoma.
Apple : Apple contains active ingredients like Chlorogenic Acid, Uvaol, Cianidanol. Intake of Chlorogenic Acid along with Fluorouracil treatment for Primary CNS Lymphoma causes a decrease in a specific biochemical pathway which is called NFKB Signaling, and this is a very positive effect. Apple hence should be eaten with Fluorouracil treatment for Primary CNS Lymphoma.
Should I take this Nutritional Supplement with Fluorouracil treatment?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP1A2 interactions with Fluorouracil treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Fluorouracil treatment efficacy in Primary CNS Lymphoma. Hence avoid using Black seed supplements with Fluorouracil treatment for this cancer.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Primary Central Nervous System Lymphoma?
In the initial stages, most cancers including Primary CNS Lymphoma may not cause any signs or symptoms. However, as the disease progresses, it may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Primary CNS Lymphoma depending on where the lymphoma is :
- Memory problems
- Difficulty concentrating
- Personality changes
- Loss of balance
- Vision problems
- Back pain which may radiate down the legs
- Numbness in the legs
- Leg and arm weakness
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Primary CNS Lymphoma.
What are the Treatment Options for Primary Central Nervous System Lymphoma?
The treatment for Primary CNS Lymphoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Primary Central Nervous System Lymphoma include:
- Steroid therapy
- Chemotherapy with or without radiation therapy
- Targeted therapy alone
- Combination of Targeted therapy and Chemotherapy
- High-dose chemotherapy with stem cell transplant
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Primary CNS Lymphoma.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Primary CNS Lymphoma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.