No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Paget Disease of the Breast needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Cranberry and Evening Primrose should be eaten when undergoing Letrozole treatment for Paget Disease of the Breast. On the same lines, avoid foods like Caraway and Custard Apple while taking Letrozole treatment for Paget Disease of the Breast. Also, Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Letrozole treatment and hence should be avoided.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers/disease conditions like Paget Disease of the Breast.
What is Paget Disease of the Breast?
Paget disease of the breast, also known as Paget’s disease of the nipple, is a rare health condition associated with breast cancer that develops an eczema-like change to the skin of the nipple. The incidence rate of this health condition is only 1.31 per 1 lakh people per year. Paget disease of the breast is commonly diagnosed in people who are about 50-60 years of age, however, it can occur in people of any age. This condition is more commonly found in Caucasian women as compared to other ethnic groups.
Paget disease of the breast has prevalence of certain genetic changes. Some of the genes such as TTN, MUC22, CCDC168, and KMT2C are known to have genetic abnormalities in this disorder resulting in a change of function.
The genetic abnormalities found in this condition can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Paget Disease of the Breast. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Paget Disease of the Breast genomics, planned or ongoing therapies (such as Letrozole) and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer may have to be redesigned.
Why Eating Right Matters for Paget Disease of the Breast?
In this disease condition, activation or inhibition of some of the biochemical pathways including P53 Signaling, Cell Cycle Checkpoints, MAPK Signaling, Growth Factor Signaling, Myc Signaling, PI3K-AKT-MTOR Signaling and Cancer Epigenetics plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Paget Disease of the Breast, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the disease progression.
Example Foods to “Not Eat” and Eat with Letrozole treatment for Paget Disease of the Breast
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Paget Disease of the Breast considering only one specific treatment.
Foods to Avoid with Letrozole treatment
Caraway : Caraway contains active ingredients such as Folic Acid, Myristicin, Retinol and others. Folic Acid interferes with the impact of Letrozole in Paget Disease of the Breast by activating a specific biochemical pathway called PI3K/AKT/MTOR Signaling. Hence, avoid taking foods like Caraway with Letrozole treatment for Paget Disease of the Breast.
Custard Apple : Custard Apple contains active ingredients such as Folic Acid, Linoleic Acid, Liriodenine and others. Folic Acid interferes with the impact of Letrozole in Paget Disease of the Breast by activating a specific biochemical pathway called PI3K/AKT/MTOR Signaling. Hence, avoid taking foods like Custard Apple with Letrozole treatment for Paget Disease of the Breast.
Foods to Eat with Letrozole treatment
Cranberry : Cranberry contains active ingredients like Hyperoside, Delphinidin and Sinapic Acid. Intake of Hyperoside along with Letrozole treatment for Paget Disease of the Breast causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Cranberry hence should be eaten with Letrozole treatment for this condition.
Evening Primrose : Evening Primrose contains active ingredients like Lupeol, Gamma-linolenic Acid and Linoleic Acid. Intake of Lupeol along with Letrozole treatment for this cancer causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Evening Primrose hence should be eaten with Letrozole treatment for this condition.
Should I take this Nutritional Supplement with Letrozole treatment?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Letrozole treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Letrozole treatment efficacy in this disease. Hence, avoid taking Black seed supplements with Letrozole treatment for this condition.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
How is Paget Disease of the Breast Diagnosed?
One or more of the following tests are usually done to diagnose Paget Disease of the Breast.
- Biopsy of the skin around the nipple
- Ultrasound scan of the breast
- In case of lump – biopsy of the breast tissue
- MRI of the breast
What are the Symptoms of Paget Disease of the Breast?
In the initial stages of Paget Disease of the Breast, skin changes around the nipple may appear and go off with topical treatment. However, as the disease progresses, it may start showing persistent symptoms.
Following are some of the signs and symptoms of Paget disease of the nipple.
- Tingling, itching or burning sensation in the nipple
- Scaly/Flaky skin around the nipple
- Flattened or inverted inpple
- Lump or thickening skin on the breast
- Yellowish or bloody coloured discharge from the nipple
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Paget Disease of the Breast.
What are the Treatment Options for this Cancer?
The treatment for Paget Disease of the Breast may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for this condition include:
- Radiation therapy
- Hormone therapy
Surgery or surgery followed by radiation is the most common treatment regimen for this condition. Radiotherapy helps to shrink the tumor. The primary role of chemotherapy is in the treatment of metastatic disease. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Paget Disease of the Breast.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Paget Disease of the Breast.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.