No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Angioimmunoblastic T-cell Lymphoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Barley and Brussels Sprout should be eaten when undergoing Azacitidine treatment for Angioimmunoblastic T-cell Lymphoma. On the same lines, avoid foods like Anise and Blackberry with treatment of Azacitidine for Angioimmunoblastic T-cell Lymphoma.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Angioimmunoblastic T-cell Lymphoma.
What is Angioimmunoblastic T-cell Lymphoma?
Angioimmunoblastic T-cell Lymphoma is a rare type of non-Hodgkin lymphoma that develops from white blood cells called T-cells/lymphocytes that become abnormal. The incidence rate of this cancer is only 0.05 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 50-70 years of age, however, it can occur in people of any age. It is more commonly found in Asians/Pacific Islanders as compared to non-Hispanic white and black population.
Angioimmunoblastic T-cell Lymphoma has prevalence of certain genetic changes. Some of the genes such as TET2, RHOA, DNMT3A, and IDH2 are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Angioimmunoblastic T-cell Lymphoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Angioimmunoblastic T-cell Lymphoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Angioimmunoblastic T-cell Lymphoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer may have to be redesigned.
Why Eating Right Matters for Angioimmunoblastic T-cell Lymphoma?
In this cancer, activation or inhibition of some of the biochemical pathways including Apoptosis, Cell Cycle, MAPK Signaling, Cytoskeletal Dynamics, Notch Signaling, Axon Guidance, MYC Signaling, Wnt Beta-catenin Signaling, Cancer Epigenetics, Epithelial To Mesenchymal Transition and PI3K-AKT-MTOR Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Angioimmunoblastic T-cell Lymphoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Azacitidine treatment for Angioimmunoblastic T-cell Lymphoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Angioimmunoblastic T-cell Lymphoma considering only one specific treatment.
Foods to Avoid with Azacitidine treatment
Anise : Anise contains active ingredients such as Apigenin, Oleic Acid, Bergapten and others. Apigenin interferes with the impact of Azacitidine in Angioimmunoblastic T cell Lymphoma by activating a specific biological process called Epithelial to Mesenchymal Transition. Hence, do not eat Anise with Azacitidine treatment for this cancer.
Blackberry : Blackberry contains active ingredients such as Ellagic Acid, Hyperoside, Quercetin and others. Ellagic Acid interferes with the impact of Azacitidine in Angioimmunoblastic T cell Lymphoma by activating a specific biochemical pathway called WNT Beta-catenin Signaling. Hence, avoid foods like Blackberry with Azacitidine treatment for Angioimmunoblastic T-cell Lymphoma.
Foods to Eat with Azacitidine treatment
Barley : Barley contains active ingredients like Beta-sitosterol, Folic Acid, Oleic Acid. Intake of Beta-sitosterol along with Azacitidine treatment for Angioimmunoblastic T cell Lymphoma causes a decrease in a specific biological process which is called Cancer Epigenetics, and this is a very positive effect. Barley hence should be eaten with Azacitidine treatment for this cancer.(Nibedita Pradhan et al, Biochim Biophys Acta Mol Basis Dis., 2019; T B Nguyen et al, Blood Cancer J., 2017; R Itzykson et al, Leukemia., 2011)
Brussels Sprout : Brussels Sprout contains active ingredients like Sulforaphane, Folic Acid, Sinapic Acid. Intake of Sulforaphane along with Azacitidine treatment for Angioimmunoblastic T cell Lymphoma causes a decrease in a specific biological process which is called Cancer Epigenetics, and this is a very positive effect. Brussels Sprout hence should be eaten with Azacitidine treatment for this cancer. (Tae Kyung Hyun et al, EXCLI J., 2020; T B Nguyen et al, Blood Cancer J., 2017; R Itzykson et al, Leukemia., 2011)
Should I take this Nutritional Supplement with Azacitidine treatment?
Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Azacitidine treatment. Black Seed supports the Azacitidine treatment for Angioimmunoblastic T cell Lymphoma by decreasing the biochemical pathways/processes like Epithelial to Mesenchymal Transition, MAPK Signaling, Cell Cycle, MYC Signaling, Notch Signaling, PI3K-AKT-MTOR Signaling, WNT Beta-catenin Signaling and increasing pathways like Apoptosis. (Lida Zhang et al, Oncol Lett., 2016; Jiuxia Pang et al, Oncotarget., 2017; Rebeca Manso et al, Haematologica., 2016; Kimberly M Sutton et al, Nutr Cancer., 2014; David Vallois et al, Blood., 2016)
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Angioimmunoblastic T-cell Lymphoma?
In the initial stages, most cancers including Angioimmunoblastic T-cell Lymphoma may not cause any signs or symptoms. However, as the disease progresses, Angioimmunoblastic T-cell Lymphoma may start showing symptoms.
Following are some of the signs and symptoms that may be caused by this cancer.
- Enlargement of lymph nodes in the neck, armpit and groin
- Swollen liver and spleen
- Skin Rash/Itchy skin
- Night sweats
- High fever
- Unexplained weight loss
- Shortness of breath
- Swollen abdomen
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Angioimmunoblastic T-cell Lymphoma.
What are the Treatment Options for Angioimmunoblastic T-cell Lymphoma?
The treatment for Angioimmunoblastic T-cell Lymphoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for this cancer include:
- Active Monitoring
- Medications like steroids
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Angioimmunoblastic T-cell Lymphoma.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Angioimmunoblastic T-cell Lymphoma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.