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What should I Eat?

is the most common question asked by cancer patients.
Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

is the most common question asked by cancer patients. Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

Get your personalized nutrition plan for cancer at 

Get your personalized nutrition plan for cancer at

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Which 3 Foods to Avoid for Anaplastic Pleomorphic Xanthoastrocytoma?

Apr 20, 2021

Home » Blogs » Which 3 Foods to Avoid for Anaplastic Pleomorphic Xanthoastrocytoma?

Highlights

No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Anaplastic Pleomorphic Xanthoastrocytoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.

Foods like Beetroot and Blueberry should be eaten when undergoing Temozolomide treatment for Anaplastic Pleomorphic Xanthoastrocytoma. On the other hand, for Anaplastic Pleomorphic Xanthoastrocytoma, Cowpea should be eaten with treatment of Radiation. On the same lines, foods like Buttermilk and Carob should be avoided with treatment of Temozolomide for Anaplastic Pleomorphic Xanthoastrocytoma. If the treatment is Radiation, then avoid Amaranth and Beetroot.

You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Anaplastic Pleomorphic Xanthoastrocytoma.



What is Anaplastic Pleomorphic Xanthoastrocytoma?

Anaplastic Pleomorphic Xanthoastrocytoma is a rare and more aggressive variant of pleomorphic xanthoastrocytoma, classified under WHO grade III astrocytoma, that develops from astrocytes, the cells in the nervous system which make up the supportive network for the brain. Unlike pleomorphic xanthoastrocytoma, it is fast growing. This cancer is commonly diagnosed in young adulthood, however, it can occur in people of any age. It is more commonly found in people of African descent as compared to other ethnic groups.

Anaplastic Pleomorphic Xanthoastrocytoma  - Symptoms, treatment, diet, foods

Anaplastic Pleomorphic Xanthoastrocytoma has prevalence of certain genetic changes. Some of the genes such as BRAF, TERT, TP53, and ZFHX3 are known to have genetic abnormalities in this cancer resulting in a change of function. 

The genetic abnormalities found in Anaplastic Pleomorphic Xanthoastrocytoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment.  In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Anaplastic Pleomorphic Xanthoastrocytoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Anaplastic Pleomorphic Xanthoastrocytoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Anaplastic Pleomorphic Xanthoastrocytoma nutrition may have to be redesigned.

Why Eating Right Matters for Anaplastic Pleomorphic Xanthoastrocytoma?

In Anaplastic Pleomorphic Xanthoastrocytoma, activation or inhibition of some of the biochemical pathways including PI3K-AKT-MTOR Signaling, MYC Signaling, Cell Cycle, Epithelial To Mesenchymal Transition, RAS-RAF Signaling, MAPK Signaling and Notch Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Anaplastic Pleomorphic Xanthoastrocytoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.

Example Foods to “Not Eat” and Eat with Temozolomide treatment for Anaplastic Pleomorphic Xanthoastrocytoma

The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Anaplastic Pleomorphic Xanthoastrocytoma considering only the treatment changes.

Foods to Avoid

Buttermilk : Buttermilk contains active ingredients such as Lauric Acid, Myristic Acid, Vitamin D3 and others. Lauric Acid interferes with the impact of Temozolomide in Anaplastic Pleomorphic Xanthoastrocytoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not eat Buttermilk with Temozolomide treatment for Anaplastic Pleomorphic Xanthoastrocytoma. (Joo Y Lee et al, J Biol Chem., 2003; Ronald P Mensink et al, m J Clin Nutr., 2003; D M Rocha et al, Atherosclerosis., 2016; Yingying Meng et al, J Agric Food Chem., 2017; Rosamaria Lappano et al, Cell Death Discov., 2017; Soumen Khatua et al, Childs Nerv Syst., 2015; Xiaoman Li et al, Oncotarget., 2016)

Carob : Carob contains active ingredients such as Folic Acid, Quercetin, Gallic Acid and others. Folic Acid interferes with the impact of Temozolomide in Anaplastic Pleomorphic Xanthoastrocytoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not eat Carob with Temozolomide treatment for Anaplastic Pleomorphic Xanthoastrocytoma. (Elena Silva et al, J Nutr., 2017; Soumen Khatua et al, Childs Nerv Syst., 2015; Xiaoman Li et al, Oncotarget., 2016)

Foods to Eat

Beetroot :  Beetroot contains active ingredients like Vitamin E, Retinol and Linolenic Acid. Intake of Vitamin E along with Temozolomide treatment for Anaplastic Pleomorphic Xanthoastrocytoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Beetroot hence should be eaten with Temozolomide treatment for this cancer. (Paul W Sylvester et al, Anticancer Agents Med Chem., 2013; Soumen Khatua et al, Childs Nerv Syst., 2015; Xiaoman Li et al, Oncotarget., 2016)

Blueberry :  Blueberry contains active ingredients like Vitamin E, Resveratrol and Hyperoside. Intake of Vitamin E along with Temozolomide treatment for Anaplastic Pleomorphic Xanthoastrocytoma causes a decrease in a specific biochemical pathway which is called  PI3K-AKT-MTOR Signaling, and this is a very positive effect. Blueberry hence should be eaten with Temozolomide treatment for Anaplastic Pleomorphic Xanthoastrocytoma. (Paul W Sylvester et al, Anticancer Agents Med Chem., 2013; Soumen Khatua et al, Childs Nerv Syst., 2015; Xiaoman Li et al, Oncotarget., 2016)

Should I take this Nutritional Supplement for Anaplastic Pleomorphic Xanthoastrocytoma?

Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Temozolomide treatment. Black Seed supports the Temozolomide treatment for Anaplastic Pleomorphic Xanthoastrocytoma by decreasing the biochemical pathways like MAPK Signaling, MYC Signaling, Notch Signaling and PI3K-AKT-MTOR Signaling, and increasing pathways like RUNX Signaling. (Mona Pazhouhi et al, Iran J Basic Med Sci., 2016; Fabliha Ahmed Chowdhury et al, Biomed Res Int., 2018; Soumen Khatua et al, Childs Nerv Syst., 2015; Xiaoman Li et al, Oncotarget., 2016)

Example Foods to “Not Eat” and Eat with Radiation treatment for Anaplastic Pleomorphic Xanthoastrocytoma

Foods to Avoid

Amaranth : Amaranth contains active ingredients such as Folic Acid, Lutein, Stigmasterol and others. Folic Acid interferes with the impact of Radiation in Anaplastic Pleomorphic Xanthoastrocytoma by activating a specific biochemical pathway called RAS-RAF Signaling. Hence, avoid foods like Amaranth with Radiation treatment for Anaplastic Pleomorphic Xanthoastrocytoma. (B D Cowley Jr et al, J Biol Chem., 1989; Joanna J Phillips et al, Acta Neuropathol., 2016; Mahmoud Toulany et al, Breast Cancer Res., 2011)

Beetroot : Beetroot contains active ingredients such as Folic Acid, Vitamin E, Retinol and others. Folic Acid interferes with the impact of Radiation in Anaplastic Pleomorphic Xanthoastrocytoma by activating a specific biochemical pathway called RAS-RAF Signaling. Hence, avoid foods like Beetroot with Radiation treatment for Anaplastic Pleomorphic Xanthoastrocytoma. (B D Cowley Jr et al, J Biol Chem., 1989; Joanna J Phillips et al, Acta Neuropathol., 2016; Mahmoud Toulany et al, Breast Cancer Res., 2011)

Foods to Eat

Cowpea :  Cowpea contains active ingredients like Quercetin, Retinol and Folic Acid. Intake of Quercetin along with Radiation treatment for Anaplastic Pleomorphic Xanthoastrocytoma causes a decrease  in a specific biochemical pathway which is called RAS-RAF Signaling, and this is a very positive effect. Cowpea hence should be eaten with Radiation treatment for this cancer. (Chenghe Lin et al, Radiother Oncol., 2012; Ki Won Lee et al, Cancer Res., 2008; Joanna J Phillips et al, Acta Neuropathol., 2016; Mahmoud Toulany et al, Breast Cancer Res., 2011)

Should I take this Nutritional Supplement for Anaplastic Pleomorphic Xanthoastrocytoma?

Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Radiation treatment. Black Seed supports the Radiation treatment for Anaplastic Pleomorphic Xanthoastrocytoma by decreasing the biochemical pathways/processes called Epithelial to Mesenchymal Transition, MYC Signaling, Notch Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle, RAS-RAF Signaling. (Fabliha Ahmed Chowdhury et al, Biomed Res Int., 2018; Lida Zhang et al, Oncol Lett., 2016)

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What are the Symptoms of Anaplastic Pleomorphic Xanthoastrocytoma?

In the initial stages, most cancers including Anaplastic Pleomorphic Xanthoastrocytoma may not cause any signs or symptoms. However, as the disease progresses, Anaplastic Pleomorphic Xanthoastrocytoma may start showing symptoms. 

Following are some of the signs and symptoms that may be caused by Anaplastic Pleomorphic Xanthoastrocytoma.

  • Seizures
  • Speech problems
  • Weakness
  • Numbness

Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Anaplastic Pleomorphic Xanthoastrocytoma.

What are the Treatment Options for Anaplastic Pleomorphic Xanthoastrocytoma?

The treatment for Anaplastic Pleomorphic Xanthoastrocytoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for this cancer include:

  • Surgery
  • Radiation
  • Chemotherapy
  • Targeted therapy

As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Anaplastic Pleomorphic Xanthoastrocytoma.

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Anaplastic Pleomorphic Xanthoastrocytoma.

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

Get started NOW with answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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