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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Anaplastic Large Cell Lymphoma!

Aug 6, 2023

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Introduction

Foods for Anaplastic Large Cell Lymphoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Anaplastic large cell lymphoma (ALCL) is a rare type of non-Hodgkin lymphoma characterized by the presence of large atypical cells in the lymph nodes. It can be associated with anaplastic lymphoma kinase (ALK) gene rearrangements. It affects T lymphocytes, a type of immune cell that help protect the body from gems and diseases. Various types of anaplastic large cell lymphoma are characterized by the location of the cancer in the body. Systemic ALCL can be either ALK gene positive or ALK negative ALCL. Other types of ALCL include primary cutaneous ALCL that affect the skin and cause bumps or rash on the skin; and breast implant associated ALCL that form around breast implant and usually diagnosed 10 years following a breast reconstruction procedure. ALK positive ALCL mostly affects pre-teens and adolescents and young adults in their 20s and 30s while the ALK-negative ALCL affects people over 60 years of age. The other ALCLs in the skin and breast affect adults over 40-50 years old. Symptoms vary depending on ALCL type. Fever, fatigue, night sweats, unexplained weight loss are some of the symptoms along with swollen lymph nodes, pain and lumps at the site where the cancer is growing. Prognosis and survival rates for ALCL vary depending on factors such as stage, ALK status, and the extent of the disease. Treatment options for ALCL may include combination chemotherapy regimens, targeted therapy, stem cell transplantation, and radiation therapy, based on individual characteristics and guidelines. Anaplastic large cell lymphoma is a serious cancer that requires careful monitoring and appropriate treatment, no matter the type. Prognosis of ALCL depends on age, spread of the cancer and number of affected lymph nodes. .



For Anaplastic Large Cell Lymphoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Anaplastic Large Cell Lymphoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Anaplastic Large Cell Lymphoma?

For example does it matter if vegetable Red Bell Pepper is consumed more compared to Rapini? Does it make any difference if fruit Longan is preferred over Evergreen Blackberry? Also if similar choices are made for nuts/seeds like Pistachio over Acorn and for pulses like Common Bean over {food_pulse1_nr1}. And if what I eat matters – then how does one identify foods which are recommended for Anaplastic Large Cell Lymphoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Anaplastic Large Cell Lymphoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Anaplastic Large Cell Lymphoma can be characterized by a unique set of biochemical pathways - the signature pathways of Anaplastic Large Cell Lymphoma. Biochemical pathways like Cell Cycle, Oncogenic Histone Methylation, Adherens junction, AGE-RAGE Signaling are part of the signature definition of Anaplastic Large Cell Lymphoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Longan contains active ingredients Apigenin, Geraniol, Daidzein, Lupeol, Luteolin. And Evergreen Blackberry contains active ingredients Geraniol, Eugenol, Ellagic Acid, Beta-ionone, Linalool and possibly others.

A common mistake made when deciding and choosing foods to eat for Anaplastic Large Cell Lymphoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Anaplastic Large Cell Lymphoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Anaplastic Large Cell Lymphoma?

Personalized nutrition for cancers like Anaplastic Large Cell Lymphoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Anaplastic Large Cell Lymphoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Anaplastic Large Cell Lymphoma

All cancers like Anaplastic Large Cell Lymphoma can be characterized by a unique set of biochemical pathways – the signature pathways of Anaplastic Large Cell Lymphoma. Biochemical pathways like Cell Cycle, Oncogenic Histone Methylation, Adherens junction, AGE-RAGE Signaling are part of the signature definition of Anaplastic Large Cell Lymphoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Anaplastic Large Cell Lymphoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Anaplastic Large Cell Lymphoma when taking cancer treatment Cyclophosphamide, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

CCND1, SETD2 and SPEN are the top ranked reported genes for Anaplastic Large Cell Lymphoma. CCND1 is reported in 100.0 % of the representative patients across all clinical trials. And SETD2 is reported in 100.0 %. The combined population patient data cover ages from to . 100.0 % of the patient data are identified as men. The Anaplastic Large Cell Lymphoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Anaplastic Large Cell Lymphoma!

Food and Supplements for Anaplastic Large Cell Lymphoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable RED BELL PEPPER or RAPINI?

Vegetable Red Bell Pepper contains many active ingredients or bioactives such as Geraniol, Capsaicin, Lupeol, Daidzein, Beta-caryophyllene. These active ingredients manipulate various biochemical pathways like Cell Cycle and others. Red Bell Pepper is recommended for Anaplastic Large Cell Lymphoma when ongoing cancer treatment is Cyclophosphamide. This is because Red Bell Pepper modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cyclophosphamide.

Some of the active ingredients or bioactives in vegetable Rapini are Apigenin, Geraniol, Lupeol, Daidzein, Luteolin. These active ingredients manipulate various biochemical pathways like Cell Cycle and others. Rapini is not recommended for Anaplastic Large Cell Lymphoma when ongoing cancer treatment is Cyclophosphamide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE RED BELL PEPPER IS RECOMMENDED OVER RAPINI FOR Anaplastic Large Cell Lymphoma AND TREATMENT Cyclophosphamide.

Choose Fruit EVERGREEN BLACKBERRY or LONGAN?

Fruit Evergreen Blackberry contains many active ingredients or bioactives such as Geraniol, Eugenol, Ellagic Acid, Beta-ionone, Linalool. These active ingredients manipulate various biochemical pathways like Cell Cycle and others. Evergreen Blackberry is recommended for Anaplastic Large Cell Lymphoma when ongoing cancer treatment is Cyclophosphamide. This is because Evergreen Blackberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cyclophosphamide.

Some of the active ingredients or bioactives in fruit Longan are Apigenin, Geraniol, Daidzein, Lupeol, Luteolin. These active ingredients manipulate various biochemical pathways like Cell Cycle and others. Longan is not recommended for Anaplastic Large Cell Lymphoma when ongoing cancer treatment is Cyclophosphamide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT EVERGREEN BLACKBERRY IS RECOMMENDED OVER LONGAN FOR Anaplastic Large Cell Lymphoma AND TREATMENT Cyclophosphamide.

Choose Nut PISTACHIO or ACORN?

Pistachio contains many active ingredients or bioactives such as Geraniol, Lupeol, Daidzein, Phloretin, Bergapten. These active ingredients manipulate various biochemical pathways like Cell Cycle and others. Pistachio is recommended for Anaplastic Large Cell Lymphoma when ongoing cancer treatment is Cyclophosphamide. This is because Pistachio modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cyclophosphamide.

Some of the active ingredients or bioactives in Acorn are Apigenin, Geraniol, Daidzein, Lupeol, Luteolin. These active ingredients manipulate various biochemical pathways like Cell Cycle and others. Acorn is not recommended for Anaplastic Large Cell Lymphoma when ongoing cancer treatment is Cyclophosphamide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

PISTACHIO IS RECOMMENDED OVER ACORN FOR Anaplastic Large Cell Lymphoma AND TREATMENT Cyclophosphamide.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Anaplastic Large Cell Lymphoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable WILD CARROT or OSTRICH FERN?

Vegetable Wild Carrot contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Vitamin D3. These active ingredients manipulate various biochemical pathways like MYC Signaling, Apoptosis, Cell Cycle and Growth Factor Signaling and others. Wild Carrot is recommended for risk of Anaplastic Large Cell Lymphoma when associated genetic risk is CCND1. This is because Wild Carrot increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Ostrich Fern are Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and Cell Cycle Checkpoints and others. Ostrich Fern is not recommended when risk of Anaplastic Large Cell Lymphoma when associated genetic risk is CCND1 because it increases the signature pathways of it.

VEGETABLE WILD CARROT IS RECOMMENDED OVER OSTRICH FERN FOR CCND1 GENETIC RISK OF CANCER.

Choose Fruit NANCE or FIG?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like MYC Signaling, Apoptosis, Cell Cycle and Growth Factor Signaling and others. Nance is recommended for risk of Anaplastic Large Cell Lymphoma when associated genetic risk is CCND1. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Fig are Curcumin, Lupeol, Daidzein, Formononetin, Phloretin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, WNT Beta Catenin Signaling and MYC Signaling and others. Fig is not recommended when risk of Anaplastic Large Cell Lymphoma when associated genetic risk is CCND1 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER FIG FOR CCND1 GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or CHESTNUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Growth Factor Signaling, WNT Beta Catenin Signaling, Cell Cycle and P53 Signaling and others. Butternut is recommended for risk of Anaplastic Large Cell Lymphoma when associated genetic risk is CCND1. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Apigenin, Curcumin, Lupeol, Ellagic Acid, Daidzein. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and Cell Cycle Checkpoints and others. Chestnut is not recommended when risk of Anaplastic Large Cell Lymphoma when associated genetic risk is CCND1 because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER CHESTNUT FOR CCND1 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Anaplastic Large Cell Lymphoma. Anaplastic Large Cell Lymphoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Anaplastic Large Cell Lymphoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Red Bell Pepper contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Anaplastic Large Cell Lymphoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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