No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Anaplastic Large Cell Lymphoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Basil and Cucumber should be eaten when undergoing Doxorubicin treatment for Anaplastic Large Cell Lymphoma. On the same lines, avoid foods like Bell Pepper and Grape with treatment of Doxorubicin for Anaplastic Large Cell Lymphoma. Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Doxorubicin treatment and hence should be avoided.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Anaplastic Large Cell Lymphoma.
What is Anaplastic Large Cell Lymphoma (ALCL)?
Anaplastic Large Cell Lymphoma (ALCL) is a rare, aggressive form of Non-Hodgkin-Lymphoma that involves the abnormal growth of a type of white blood cells called T-cells or T-Lymphocytes. The incidence rate of this cancer is only 0.2 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 40-65 years of age, however, it can occur in people of any age. It is more commonly found in men as compared to women.
ALCL has prevalence of certain genetic changes. Some of the genes such as NPM1-ALK, NOTCH1, STAT3, and SF3B1 are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in ALCL can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for ALCL. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Anaplastic Large Cell Lymphoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer nutrition may have to be redesigned.
Why Eating Right Matters for Anaplastic Large Cell Lymphoma?
In ALCL, activation or inhibition of some of the biochemical pathways including Epithelial To Mesenchymal Transition, Apoptosis, P53 Signaling, RAS-RAF Signaling, Wnt Beta-catenin Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling, MYC Signaling, Cancer Epigenetics and Cell Cycle Checkpoints plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Anaplastic Large Cell Lymphoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Doxorubicin treatment for Anaplastic Large Cell Lymphoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Anaplastic Large Cell Lymphoma considering only one specific treatment.
Foods to Avoid with Doxorubicin treatment
Bell Pepper : Bell Pepper contains active ingredients such as Capsaicin, Vitamin C, Vitamin E and others. Capsaicin interferes with the impact of Doxorubicin in Anaplastic Large Cell Lymphoma by activating a specific biochemical pathway called MAPK Signaling. Hence, avoid foods like Bell Pepper with Doxorubicin treatment for Anaplastic Large Cell Lymphoma. (Cheol-Hee Choi et al, Mol Pharmacol., 2010; Sophie Malagarie-Cazenave et al, FEBS Lett., 2009; Consuelo Amantini et al, Oncotarget., 2016; Jennifer Choi et al, J Surg Res., 2008; Ryo Yamamoto et al, Cancer Sci., 2009)
Grape : Grape contains active ingredients such as Linoleic Acid, Pelargonidin, Epicatechin and others. Linoleic Acid interferes with the impact of Doxorubicin in Anaplastic Large Cell Lymphoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not eat Grape with Doxorubicin treatment for ALCL. (Katia Mariniello et al, Nutrition., 2019; Maria Carolina S Moraes et al, Cancer Lett., 2012; Fabrizio Tabbó et al, Front Oncol., 2012; Greg Hapgood et al, Blood., 2015)
Foods to Eat with Doxorubicin treatment
Basil : Basil contains active ingredients like Betulinic Acid, Trans-trans-farnesol, Quercetin. Intake of Betulinic Acid along with Doxorubicin treatment for Anaplastic Large Cell Lymphoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Basil hence should be eaten with Doxorubicin treatment for ALCL. (Tao Xu et al, Int J Mol Med., 2017; Maria Carolina S Moraes et al, Cancer Lett., 2012; Fabrizio Tabbó et al, Front Oncol., 2012; Greg Hapgood et al, Blood., 2015)
Cucumber : Cucumber contains active ingredients like Lupeol, Vitamin C, Salicylic Acid. Intake of Lupeol along with Doxorubicin treatment for Anaplastic Large Cell Lymphoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Cucumber hence should be eaten with Doxorubicin treatment for ALCL. (Mohammad Saleem et al, Oncogene., 2004; Maria Carolina S Moraes et al, Cancer Lett., 2012; Fabrizio Tabbó et al, Front Oncol., 2012; Greg Hapgood et al, Blood., 2015)
Should I take this Nutritional Supplement with Doxorubicin treatment?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Doxorubicin treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Doxorubicin treatment efficacy in ALCL. Hence avoid taking Black seed supplements with Doxorubicin treatment for this cancer type. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Pius S Fasinu et al, Front Oncol., 2019)
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Anaplastic Large Cell Lymphoma?
In the initial stages, most cancers including Anaplastic Large Cell Lymphoma may not cause any signs or symptoms. However, as the disease progresses, it may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Anaplastic Large Cell Lymphoma.
- Painless swelling in neck, armpit or groin
- Night sweats
- High fever
- Loss of appetite
- Unexplained weight less
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Anaplastic Large Cell Lymphoma.
What are the Treatment Options for Anaplastic Large Cell Lymphoma?
The treatment for Anaplastic Large Cell Lymphoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Anaplastic Large Cell Lymphoma include:
- Stem cell transplantation
Chemotherapy is the most common treatment regimen for ALCL. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Anaplastic Large Cell Lymphoma.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Anaplastic Large Cell Lymphoma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.