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What should I Eat?

is the most common question asked by cancer patients.
Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

is the most common question asked by cancer patients. Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

Get your personalized nutrition plan for cancer at 

Get your personalized nutrition plan for cancer at

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Which 3 Foods to Avoid for Testicular Germ Cell Tumors?

Apr 16, 2021

Home » Blogs » Which 3 Foods to Avoid for Testicular Germ Cell Tumors?

Highlights

No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Testicular Germ Cell Tumors needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.

Foods like Black Tea and Carrot should be taken when undergoing Bleomycin treatment for Testicular Germ Cell Tumors. On the other hand, Bottle Gourd and Butter should be eaten with treatment of Cisplatin. On the same lines, avoid foods like Common Bean with treatment of Bleomycin for this Cancer. If the treatment is Cisplatin, then avoid Caraway and Cherry.

Similarly, Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Cisplatin treatment and hence should be avoided. However, Black Seed supplements do not have any known CYP interactions with Bleomycin treatment.

You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Testicular Germ Cell Tumors.



What is Testicular Germ Cell Tumors (TGCTs)?

Testicular Germ Cell Tumors is a rare cancer that develops in the testicles which starts in reproductive/germ cells that turn into sperm. The incidence rate of this cancer varies from 1.2 (in Non-Hispanic black men) to 6.57 (in non-Hispanic white men) per 1 lakh people per year in the United States. This cancer is commonly diagnosed in men who are between 15-49 years of age, however, it can occur in men aged above 49 too. It is more commonly found in non-Hispanic whites as compared to Hispanics, Asian/Pacific Islanders, and non-Hispanic blacks.

Testicular Germ Cell Tumors - Symptoms, Treatment, Diet, Foods

TGCTs have prevalence of certain genetic changes. Some of the genes such as KIT, KRAS, PTMA, and TTN are known to have genetic abnormalities in this cancer resulting in a change of function. 

The genetic abnormalities found in this cancer can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment.  In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Testicular Germ Cell Tumors. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of TGCTs genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer may have to be redesigned.

Why Eating Right Matters for Testicular Germ Cell Tumors?

In Testicular Germ Cell Tumors, activation or inhibition of some of the biochemical pathways including Oxidative Stress, Hypoxia, Cell Cycle, MAPK Signaling, Wnt Beta-catenin Signaling, Post Translational Modification, RAS-RAF Signaling, Heat Stress Response and PI3K-AKT-MTOR Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Testicular Germ Cell Tumors, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.

Example Foods to “Not Eat” and Eat with Bleomycin treatment for Testicular Germ Cell Tumors

The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Testicular Germ Cell Tumors considering only the treatment changes.

Foods to Avoid

Common Bean : Common Bean contains active ingredients such as Apigenin, Oleic Acid, Gamma-linolenic Acid and others. Apigenin interferes with the impact of Bleomycin in Testicular Germ Cell Tumors by activating a specific biological process called Heat Stress Response. Hence, do not eat Common Bean with Bleomycin treatment for this cancer.

Foods to Eat

Black Tea :  Black Tea contains active ingredients like Linalool, Theaflavin and 3-hydroxyflavone. Intake of Linalool along with Bleomycin treatment for TGCTs causes a decrease  in a specific biochemical pathway which is called RAS-RAF Signaling, and this is a very positive effect. Black Tea hence should be taken with Bleomycin treatment for this cancer.

Carrot :  Carrot contains active ingredients like Linalool, Gamma-linolenic Acid and Osthole. As mentioned above, the intake of Linalool along with Bleomycin treatment for Testicular Germ Cell Tumors causes a decrease  in a specific biochemical pathway which is called  RAS-RAF Signaling, and this is a very positive effect. Carrot hence should be eaten with Bleomycin treatment for this cancer.

Should I take this Nutritional Supplement for Testicular Germ Cell Tumors?

Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Bleomycin treatment. Black Seed supports the Bleomycin treatment for Testicular Germ Cell Tumors by decreasing the biochemical pathways/processes like MAPK Signaling, JAK-STAT Signaling, MYC Signaling, NFKB Signaling, Inflammation, PI3K-AKT-MTOR Signaling, Cell Cycle, DNA Repair, Cytoskeletal Dynamics, C-type Lectin Receptor Signaling and RAS-RAF Signaling and increasing pathways like Oxidative Stress.

Example Foods to “Not Eat” and Eat with Cisplatin treatment for Testicular Germ Cell Tumors

Foods to Avoid

Caraway : Caraway contains active ingredients such as Caffeic Acid, Folic Acid, D-limonene and others. Caffeic Acid interferes with the impact of Cisplatin in Testicular Germ Cell Tumors by blocking a specific biological process called Post Translation Modification. Hence, do not eat Caraway with Cisplatin treatment for this cancer.

Cherry : Cherry contains active ingredients such as Chlorogenic Acid, Oleic Acid, Isorhamnetin and others. Chlorogenic Acid interferes with the impact of Cisplatin in Testicular Germ Cell Tumors by blocking a specific biological process called Oxidative Stress. Hence, do not eat Cherry with Cisplatin treatment for this cancer.

Foods to Eat

Bottle Gourd :  Bottle Gourd contains active ingredients like Beta-sitosterol, Oleic Acid, Linolenic Acid. Intake of Beta-sitosterol along with Cisplatin treatment for Testicular Germ Cell Tumors causes a decrease  in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Bottle Gourd hence should be eaten with Cisplatin treatment for this cancer.

Butter :  Butter contains active ingredients like Daidzein, Oleic Acid, Linolenic Acid. Intake of Daidzein along with Cisplatin treatment for Testicular Germ Cell Tumors causes a decrease  in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Butter hence should be taken with Cisplatin treatment for this cancer.

Should I take this Nutritional Supplement for Testicular Germ Cell Tumors?

Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Cisplatin treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Cisplatin treatment efficacy in TGCTs. Hence, avoid taking Black seed supplements with Cisplatin treatment for this cancer.

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What are the Symptoms of this Cancer?

In the initial stages, most cancers including Testicular Germ Cell Tumors may not cause any signs or symptoms. However, as the disease progresses, Testicular Germ Cell Tumors may start showing symptoms. 

Following are some of the signs and symptoms that may be caused by this cancer.

  • A lump in the testicle.
  • Swelling
  • Heaviness in the scrotum
  • Pain in the testicle or scrotum
  • Stomach or groin pain

Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Testicular Germ Cell Tumors.

What are the Treatment Options for this Cancer?

The treatment for Testicular Germ Cell Tumors may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for this cancer include:

  • Surgery
  • Radiotherapy
  • Chemotherapy

Surgery or surgery followed by radiation is the most common treatment regimen for this cancer. Radiotherapy helps to shrink the tumor. This cancer is highly sensitive to chemotherapy. Chemo is also used when the cancer has spread or metastasized to other parts. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Testicular Germ Cell Tumors.

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Testicular Germ Cell Tumors.

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

Get started NOW with answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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