No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Mantle Cell Lymphoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Bamboo and Bottle Gourd should be eaten when undergoing Doxorubicin treatment for Mantle Cell Lymphoma. On the same lines, avoid foods like Cucumber and Mung Bean avoided with treatment of Doxorubicin for Mantle Cell Lymphoma. Also, Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Doxorubicin treatment and hence should be avoided.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Mantle Cell Lymphoma.
What is Mantle Cell Lymphoma?
Mantle Cell Lymphoma is a rare type of Non-Hodgkin Lymphoma that develops from B cells. The incidence rate of this cancer is only 0.5 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 60 to 70 years years of age, however, it can occur in people of any age. It is more commonly found in men as compared to women.
Mantle Cell Lymphoma has prevalence of certain genetic changes. Some of the genes such as ATM, KMT2D, UBR5, and TP53 are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in this cancer can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Mantle Cell Lymphoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Mantle Cell Lymphoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer may have to be redesigned.
Why Eating Right Matters for Mantle Cell Lymphoma?
In Mantle Cell Lymphoma, activation or inhibition of some of the biochemical pathways including Apoptosis, MAPK Signaling, P53 Signaling, Cell Cycle Checkpoints, DNA Repair, Amino Acid Metabolism, Vitamin D Signaling, Angiogenesis, MYC Signaling, Cancer Epigenetics and PI3K-AKT-MTOR Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Mantle Cell Lymphoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Doxorubicin treatment for Mantle Cell Lymphoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Mantle Cell Lymphoma considering only the treatment changes.
Foods to Avoid with Doxorubicin treatment
Cucumber : Cucumber contains active ingredients such as Caffeic Acid, Oleic Acid, Linolenic Acid and others. Caffeic Acid interferes with the impact of Doxorubicin in Mantle Cell Lymphoma by blocking a specific biochemical pathway called Vitamin D Signaling. Hence, do not eat Cucumber with Doxorubicin treatment for this cancer.
Mung Bean : Mung Bean contains active ingredients such as Folic Acid, Oleic Acid, Linolenic Acid and others. Folic Acid interferes with the impact of Doxorubicin in Mantle Cell Lymphoma by blocking a specific biochemical pathway called Vitamin D Signaling. Hence, do not eat Mung Bean with Doxorubicin treatment for this cancer.
Foods to Eat with Doxorubicin treatment
Bamboo : Bamboo contains active ingredients like Beta-sitosterol, Oleic Acid, Linolenic Acid. Intake of Beta-sitosterol along with Doxorubicin treatment for Mantle Cell Lymphoma causes an increase in a specific biochemical pathway which is called P53 Signaling, and this is a very positive effect. Bamboo hence should be eaten with Doxorubicin treatment for this cancer.
Bottle Gourd : Bottle Gourd contains active ingredients like Beta-sitosterol, Oleic Acid, Linolenic Acid. Intake of Beta-sitosterol along with Doxorubicin treatment for Mantle Cell Lymphoma causes an increase in a specific biochemical pathway which is called P53 Signaling, and this is a very positive effect. Bottle Gourd hence should be eaten with Doxorubicin treatment for this cancer.
Should I take this Nutritional Supplement with Doxorubicin treatment?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Doxorubicin treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Doxorubicin treatment efficacy in Mantle Cell Lymphoma. Hence, avoid taking Black seed supplements with Doxorubicin treatment for this Cancer.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of this Cancer?
In the initial stages, most cancers including Mantle Cell Lymphoma may not cause any signs or symptoms. However, as the disease progresses, it may start showing symptoms.
Following are some of the signs and symptoms that may be caused by this cancer.
- Swelling of the lymph nodes
- Discomfort due to enlarged tonsil, liver, or spleen
- High fever
- Loss of appetite
- Night sweats
- Unexplained weight loss
- Lower back pain
- Bloating in the stomach
- Indigestion or stomach pain
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Mantle Cell Lymphoma.
What are the Treatment Options for this Cancer?
The treatment for Mantle Cell Lymphoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history. The treatment options for this cancer include:
- Targeted therapy
- Stem cell transplantation
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Mantle Cell Lymphoma.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Mantle Cell Lymphoma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.