Foods for Mantle Cell Lymphoma!

Introduction

Foods for Mantle Cell Lymphoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Mantle cell lymphoma (MCL) is a type of cancer that affects the lymphatic system. Accurate medical coding using the ICD-10 code ensures proper documentation of Mantle cell lymphoma cases. Pathology outlines play an essential role in understanding the characteristic features of MCL. Treatment options for MCL may include various approaches such as targeted therapy, chemotherapy, immunotherapy, stem cell transplantation, and radiation therapy. Prognosis for MCL varies depending on several factors, including the stage and specific subtype of the disease. Survival rates for MCL have improved over the years as a result of advances in treatment and supportive care. It is crucial to pay attention to symptoms that may include enlarged lymph nodes, fatigue, night sweats, and weight loss. The blastoid variant of MCL is a more aggressive form that requires prompt and intensive treatment. Various markers help in diagnosing and monitoring MCL, providing insights into disease progression and response to treatment. Genetic mutations are known to contribute to the development of MCL. Clinical trials are constantly investigating new treatment approaches and strategies for MCL. Understanding risk factors associated with MCL and staying informed about the latest research developments can aid in proactive management and treatment decision-making. By collaborating closely with healthcare professionals, individuals with MCL can access the latest treatment protocols and improve their chances of successful outcomes.

For Mantle Cell Lymphoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Mantle Cell Lymphoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Mantle Cell Lymphoma?

For example does it matter if vegetable Cauliflower is consumed more compared to Arrowroot? Does it make any difference if fruit Sea-buckthornberry is preferred over Red Raspberry? Also if similar choices are made for nuts/seeds like Butternut over Cashew Nut and for pulses like Broad Bean over Lentils. And if what I eat matters – then how does one identify foods which are recommended for Mantle Cell Lymphoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Mantle Cell Lymphoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Sea-buckthornberry contains active ingredients Apigenin, Curcumin, Lycopene, Lupeol, Isoliquiritigenin. And Red Raspberry contains active ingredients Quercetin, Curcumin, Ellagic Acid, Lupeol, Isoliquiritigenin and possibly others.

A common mistake made when deciding and choosing foods to eat for Mantle Cell Lymphoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Mantle Cell Lymphoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Mantle Cell Lymphoma?

Personalized nutrition for cancers like Mantle Cell Lymphoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Mantle Cell Lymphoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Mantle Cell Lymphoma

All cancers like Mantle Cell Lymphoma can be characterized by a unique set of biochemical pathways – the signature pathways of Mantle Cell Lymphoma. Biochemical pathways like Vitamin Metabolism, Cell Cycle Checkpoints, Cell Cycle, Oncogenic Histone Methylation are part of the signature definition of Mantle Cell Lymphoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Mantle Cell Lymphoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Mantle Cell Lymphoma when taking cancer treatment Cyclophosphamide, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

CDC27, FAT1, RYR3, ASH1L and KMT2C are the top ranked reported genes for Mantle Cell Lymphoma. CDC27 is reported in 11.4 % of the representative patients across all clinical trials. And FAT1 is reported in 5.9 %. The combined population patient data cover ages from to . 72.7 % of the patient data are identified as men. The Mantle Cell Lymphoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Mantle Cell Lymphoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CAULIFLOWER or ARROWROOT?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Lupeol, Isoliquiritigenin, Phloretin, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Cell Cycle Checkpoints, NFKB Signaling and PI3K-AKT-MTOR Signaling and others. Cauliflower is recommended for Mantle Cell Lymphoma when ongoing cancer treatment is Cyclophosphamide. This is because Cauliflower modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cyclophosphamide.

Some of the active ingredients or bioactives in vegetable Arrowroot are Quercetin, Apigenin, Curcumin, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, DNA Repair and Amino Acid Metabolism and others. Arrowroot is not recommended for Mantle Cell Lymphoma when ongoing cancer treatment is Cyclophosphamide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER ARROWROOT FOR Mantle Cell Lymphoma AND TREATMENT Cyclophosphamide.

Choose Fruit RED RASPBERRY or SEA-BUCKTHORNBERRY?

Fruit Red Raspberry contains many active ingredients or bioactives such as Quercetin, Curcumin, Ellagic Acid, Lupeol, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Cell Cycle Checkpoints, NFKB Signaling and PI3K-AKT-MTOR Signaling and others. Red Raspberry is recommended for Mantle Cell Lymphoma when ongoing cancer treatment is Cyclophosphamide. This is because Red Raspberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cyclophosphamide.

Some of the active ingredients or bioactives in fruit Sea-buckthornberry are Apigenin, Curcumin, Lycopene, Lupeol, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, DNA Repair and Amino Acid Metabolism and others. Sea-buckthornberry is not recommended for Mantle Cell Lymphoma when ongoing cancer treatment is Cyclophosphamide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RED RASPBERRY IS RECOMMENDED OVER SEA-BUCKTHORNBERRY FOR Mantle Cell Lymphoma AND TREATMENT Cyclophosphamide.

Choose Nut BUTTERNUT or CASHEW NUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Lycopene, Lupeol, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, DNA Repair, Amino Acid Metabolism and Cell Survival and others. Butternut is recommended for Mantle Cell Lymphoma when ongoing cancer treatment is Cyclophosphamide. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cyclophosphamide.

Some of the active ingredients or bioactives in Cashew Nut are Quercetin, Curcumin, Lupeol, Isoliquiritigenin, Phloretin. These active ingredients manipulate various biochemical pathways like MAPK Signaling and NFKB Signaling and others. Cashew Nut is not recommended for Mantle Cell Lymphoma when ongoing cancer treatment is Cyclophosphamide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER CASHEW NUT FOR Mantle Cell Lymphoma AND TREATMENT Cyclophosphamide.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Mantle Cell Lymphoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or MALABAR SPINACH?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, EPHRIN Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Giant Butterbur is recommended for risk of Mantle Cell Lymphoma when associated genetic risk is ASH1L. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Malabar Spinach are Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and DNA Repair and others. Malabar Spinach is not recommended when risk of Mantle Cell Lymphoma when associated genetic risk is ASH1L because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER MALABAR SPINACH FOR ASH1L GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, EPHRIN Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Nance is recommended for risk of Mantle Cell Lymphoma when associated genetic risk is ASH1L. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and DNA Repair and others. Pummelo is not recommended when risk of Mantle Cell Lymphoma when associated genetic risk is ASH1L because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR ASH1L GENETIC RISK OF CANCER.

Choose Nut BLACK WALNUT or CHESTNUT?

Black Walnut contains many active ingredients or bioactives such as Apigenin, Curcumin, Ellagic Acid, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, MYC Signaling, Apoptosis and PI3K-AKT-MTOR Signaling and others. Black Walnut is recommended for risk of Mantle Cell Lymphoma when associated genetic risk is ASH1L. This is because Black Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Apigenin, Curcumin, Ellagic Acid, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair and PI3K-AKT-MTOR Signaling and others. Chestnut is not recommended when risk of Mantle Cell Lymphoma when associated genetic risk is ASH1L because it increases the signature pathways of it.

BLACK WALNUT IS RECOMMENDED OVER CHESTNUT FOR ASH1L GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Mantle Cell Lymphoma. Mantle Cell Lymphoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Mantle Cell Lymphoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cauliflower contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Mantle Cell Lymphoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

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