No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short the answer to “What Should I Eat” for Dermatofibrosarcoma Protuberans – needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Allspice and Almond should be eaten when undergoing Radiation treatment for Dermatofibrosarcoma Protuberans. On the other hand, for Dermatofibrosarcoma Protuberans, Blueberry and Fava Bean should be eaten with treatment of Imatinib. On the same lines, avoid foods like Barley and Brussels Sprout with treatment of Radiation for Dermatofibrosarcoma Protuberans. If the treatment is Imatinib, then avoid Anise and Caraway.
Also, Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Imatinib treatment and hence should be avoided. However, Black Seed supplements have no known adverse interactions with Radiation treatment.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Dermatofibrosarcoma Protuberans.
What is Dermatofibrosarcoma Protuberans?
Dermatofibrosarcoma Protuberans is a rare type of soft tissue sarcoma that develops in the deep layers of the skin. The incidence rate of this cancer is only 0.31-0.44 per 1 lakh people per year. This cancer is commonly diagnosed in people who are aged between 20 to 50 years, however, it can occur in people of any age. It is more commonly found in African Americans as compared to American White population.
Dermatofibrosarcoma Protuberans has prevalence of certain genetic changes. Some of the genes such as PIK3C2B, CDKN2A, POLE, and ASXL1 are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Dermatofibrosarcoma Protuberans can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Dermatofibrosarcoma Protuberans. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Dermatofibrosarcoma Protuberans genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer may have to be redesigned.
Why Eating Right Matters for Dermatofibrosarcoma Protuberans?
In Dermatofibrosarcoma Protuberans, activation or inhibition of some of the biochemical pathways including DNA Repair, PI3K-AKT-MTOR Signaling, Growth Factor Signaling, P53 Signaling, RAS-RAF Signaling, Cell Cycle, MYC Signaling and Cancer Epigenetics plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Dermatofibrosarcoma Protuberans, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Radiation treatment for Dermatofibrosarcoma Protuberans
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Dermatofibrosarcoma Protuberans considering only the treatment changes.
Foods to Avoid with Radiation treatment
Barley : Barley contains active ingredients such as Esculin, Beta-sitosterol, Oleic Acid and others. Esculin interferes with the impact of Radiation in Dermatofibrosarcoma Protuberans by activating a specific biological process called DNA Repair. Hence, avoid foods like Barley with Radiation treatment for Dermatofibrosarcoma Protuberans.
Brussels Sprout : Brussels Sprout contains active ingredients such as Folic Acid, Sinapic Acid, Beta-sitosterol and others. Folic Acid interferes with the impact of Radiation in Dermatofibrosarcoma Protuberans by activating a specific biochemical pathway called Growth Factor Signaling. Hence, do not eat Brussels Sprout with Radiation treatment for this cancer.
Foods to Eat with Radiation treatment
Allspice : Allspice contains active ingredients like Salicylic Acid, Eucalyptol and Methyleugenol. Intake of Salicylic Acid along with Radiation treatment for Dermatofibrosarcoma Protuberans causes a decrease in a specific biological process which is called DNA Repair, and this is a very positive effect. Allspice hence should be eaten with Radiation treatment for this cancer.
Almond : Almond contains active ingredients like Salicylic Acid, Beta-sitosterol and Oleic Acid. Intake of Salicylic Acid along with Radiation treatment for Dermatofibrosarcoma Protuberans causes a decrease in a specific biological process which is called DNA Repair, and this is a very positive effect. Almond hence should be eaten with Radiation treatment for this cancer.
Should I take this Nutritional Supplement with Radiation treatment ?
Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Radiation treatment. Black Seed supports the Radiation treatment for Dermatofibrosarcoma Protuberans by decreasing the biochemical pathways/processes called MYC Signaling, Notch Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle, DNA Repair, TGFB Signaling and RAS-RAF Signaling.
Example Foods to “Not Eat” and Eat with Imatinib treatment for Dermatofibrosarcoma Protuberans
Foods to Avoid with Imatinib treatment
Anise : Anise contains active ingredients such as Apigenin, Caffeic Acid, Eucalyptol and others. Apigenin interferes with the impact of Imatinib in Dermatofibrosarcoma Protuberans by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not eat Anise with Imatinib treatment for this cancer.
Caraway : Caraway contains active ingredients such as Caffeic Acid, Linalool, Myrcene and others. Caffeic Acid interferes with the impact of Imatinib in Dermatofibrosarcoma Protuberans by blocking a specific biochemical pathway called RAS-RAF Signaling. Hence, do not eat Caraway with Imatinib treatment for this cancer.
Foods to Eat with Imatinib treatment
Blueberry : Blueberry contains active ingredients like Hyperoside, Caffeic Acid and Pelargonidin. Intake of Hyperoside along with Imatinib treatment for Dermatofibrosarcoma Protuberans causes a decrease in a specific biological process which is called Cell Cycle, and this is a very positive effect. Blueberry hence should be eaten with Imatinib treatment for this cancer.
Fava Bean : Fava Bean contains active ingredients like Butein, Astragalin and Epicatechin. Intake of Butein along with Imatinib treatment for Dermatofibrosarcoma Protuberans causes a decrease in a specific biological process which is called Cell Cycle, and this is a very positive effect. Fava Bean hence should be eaten with Imatinib treatment for this cancer.
Should I take this Nutritional Supplement with Imatinib treatment?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4, CYP1A2 and CYP2C9 interactions with Imatinib treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Imatinib treatment efficacy in Dermatofibrosarcoma Protuberans. Hence avoid taking Black Seed supplements with Imatinib treatment for this cancer.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Dermatofibrosarcoma Protuberans?
In the initial stages, most cancers including Dermatofibrosarcoma Protuberans may not cause any signs or symptoms. However, as the disease progresses, it may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Dermatofibrosarcoma Protuberans.
- A pimple-like thickened area or nodule fixed to the underlying skin.
- Rubbery or firm nodules, usually reddish-brown or skin coloured
- No pain or tenderness where the plaque or nodule forms
- Little change in the growth or patch.
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Dermatofibrosarcoma Protuberans.
What are the Treatment Options for Dermatofibrosarcoma Protuberans?
The treatment for Dermatofibrosarcoma Protuberans may be decided based on different factors including the cancer characteristics, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for this cancer include:
- Radiation therapy
- Targeted Therapy
Surgery or surgery followed by radiation is the most common treatment regimen for Dermatofibrosarcoma Protuberans. Radiotherapy helps to shrink the tumor. Chemotherapy does not seem to be effective for this cancer. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Dermatofibrosarcoma Protuberans.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Dermatofibrosarcoma Protuberans.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.