No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Chronic Neutrophilic Leukemia needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Basil and Black Tea should be taken when undergoing Vinblastine treatment for Chronic Neutrophilic Leukemia. On the same lines, foods like Bottle Gourd and Caraway should be avoided with treatment of Vinblastine for Chronic Neutrophilic Leukemia. Also, Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Vinblastine treatment and hence should be avoided.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Chronic Neutrophilic Leukemia.
What is Chronic Neutrophilic Leukemia (CNL)?
Chronic Neutrophilic Leukemia (CNL) is a rare myeloproliferative neoplasm that develops from the bone marrow, causing the body to make abnormally high numbers of neutrophils – the white blood cells that protects the body from infections. The incidence rate of this cancer is only 0.01 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 66 years of age, however, it can occur in people of any age. It is found in both men and women equally.
CNL has prevalence of certain genetic changes. Some of the genes such as ASXL1, TET2, SRSF2, and CSF3R are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in CNL can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Chronic Neutrophilic Leukemia. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Chronic Neutrophilic Leukemia genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer may have to be redesigned.
Why Eating Right Matters for Chronic Neutrophilic Leukemia?
In CNL, activation or inhibition of some of the biochemical pathways including Oxidative Stress, Hypoxia, Apoptosis, Cell Cycle, MRNA Splicing, Cancer Epigenetics, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Chronic Neutrophilic Leukemia, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Vinblastine treatment for Chronic Neutrophilic Leukemia
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Chronic Neutrophilic Leukemia considering only one specific treatment.
Foods to Avoid with Vinblastine treatment
Bottle Gourd : Bottle Gourd contains active ingredients such as Linoleic Acid, Oleic Acid, Linolenic Acid and others. Linoleic Acid interferes with the impact of Vinblastine in Chronic Neutrophilic Leukemia by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, avoid foods like Bottle Gourd with Vinblastine treatment for Chronic Neutrophilic Leukemia. (Katia Mariniello et al, Nutrition., 2019; David J Vanderweele et al, Mol Cancer Res., 2005; Natasha Szuber et al, Blood Cancer J., 2018)
Caraway : Caraway contains active ingredients such as Folic Acid, D-limonene, Linolenic Acid and others. Folic Acid interferes with the impact of Vinblastine in Chronic Neutrophilic Leukemia by activating a specific biochemical pathway called RAS-RAF Signaling. Hence, do not eat Caraway with Vinblastine treatment for CNL. (B D Cowley Jr et al, J Biol Chem., 1989; Koichi Oshima et al, Proc Natl Acad Sci U S A., 2016; Natasha Szuber et al, Blood Cancer J., 2018)
Foods to Eat with Vinblastine treatment
Basil : Basil contains active ingredients like Linalool, P-coumaric Acid and Isoeugenol. Intake of Linalool along with Vinblastine treatment for Chronic Neutrophilic Leukemia causes a decrease in a specific biochemical pathway which is called RAS-RAF Signaling, and this is a very positive effect. Basil hence should be eaten with Vinblastine treatment for CNL. (Sung-Yun Cho et al, FEBS Lett., 2011; Koichi Oshima et al, Proc Natl Acad Sci U S A., 2016; Natasha Szuber et al, Blood Cancer J., 2018)
Black Tea : Black Tea contains active ingredients like Linalool, Theaflavin and 3-hydroxyflavone. Intake of Linalool along with Vinblastine treatment for Chronic Neutrophilic Leukemia causes a decrease in a specific biochemical pathway which is called RAS-RAF Signaling, and this is a very positive effect. Black Tea hence should be taken with Vinblastine treatment for CNL. (Sung-Yun Cho et al, FEBS Lett., 2011; Mark E Stearns et al, Transl Oncol. 2011; Koichi Oshima et al, Proc Natl Acad Sci U S A., 2016; Natasha Szuber et al, Blood Cancer J., 2018)
Should I take this Nutritional Supplement with Vinblastine treatment?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Vinblastine treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Vinblastine treatment efficacy in CNL. Hence, avoid taking Black Seed supplements with Vinblastine treatment for this cancer. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Pius S Fasinu et al, Front Oncol., 2019)
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Chronic Neutrophilic Leukemia?
In the initial stages, most cancers including Chronic Neutrophilic Leukemia may not cause any signs or symptoms. However, as the disease progresses, it may start showing symptoms.
Following are some of the signs and symptoms that may be caused by CNL.
- Bone pain
- Night sweats
- Enlarged spleen/liver.
- Loss of Weight
- Easy bruising
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Chronic Neutrophilic Leukemia.
What are the Treatment Options for Chronic Neutrophilic Leukemia?
The treatment for Chronic Neutrophilic Leukemia may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, and whether the cancer was just diagnosed or had come back. The treatment options for CNL include:
- Radiation Therapy
- Stem Cell transplantation
- Targeted Therapy
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Chronic Neutrophilic Leukemia.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Chronic Neutrophilic Leukemia.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.