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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Anaplastic Oligoastrocytoma!

Aug 3, 2023

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Introduction

Foods for Anaplastic Oligoastrocytoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.



For Anaplastic Oligoastrocytoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Anaplastic Oligoastrocytoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Anaplastic Oligoastrocytoma?

For example does it matter if vegetable Garden Cress is consumed more compared to Carob? Does it make any difference if fruit Pummelo is preferred over Pomegranate? Also if similar choices are made for nuts/seeds like Common Walnut over Macadamia Nut and for pulses like Broad Bean over Lima Bean. And if what I eat matters – then how does one identify foods which are recommended for Anaplastic Oligoastrocytoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Anaplastic Oligoastrocytoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Anaplastic Oligoastrocytoma can be characterized by a unique set of biochemical pathways - the signature pathways of Anaplastic Oligoastrocytoma. Biochemical pathways like DNA Repair, Hypoxia, Apoptosis, Cell Cycle Checkpoints are part of the signature definition of Anaplastic Oligoastrocytoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Apigenin, Curcumin, Caffeine, Quercetin, Daidzein. And Pomegranate contains active ingredients Apigenin, Curcumin, Quercetin, Ellagic Acid, Daidzein and possibly others.

A common mistake made when deciding and choosing foods to eat for Anaplastic Oligoastrocytoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Anaplastic Oligoastrocytoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Anaplastic Oligoastrocytoma?

Personalized nutrition for cancers like Anaplastic Oligoastrocytoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Anaplastic Oligoastrocytoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Anaplastic Oligoastrocytoma

All cancers like Anaplastic Oligoastrocytoma can be characterized by a unique set of biochemical pathways – the signature pathways of Anaplastic Oligoastrocytoma. Biochemical pathways like DNA Repair, Hypoxia, Apoptosis, Cell Cycle Checkpoints are part of the signature definition of Anaplastic Oligoastrocytoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Anaplastic Oligoastrocytoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Anaplastic Oligoastrocytoma when taking cancer treatment Temozolomide, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, TERT, NOTCH2, IDH1 and EIF1AX are the top ranked reported genes for Anaplastic Oligoastrocytoma. TP53 is reported in 64.7 % of the representative patients across all clinical trials. And TERT is reported in 17.6 %. The combined population patient data cover ages from 30 to 56. 58.8 % of the patient data are identified as men. The Anaplastic Oligoastrocytoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Anaplastic Oligoastrocytoma!

Food and Supplements for Anaplastic Oligoastrocytoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GARDEN CRESS or CAROB?

Vegetable Garden Cress contains many active ingredients or bioactives such as Curcumin, Daidzein, Lupeol, Phloretin, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, PI3K-AKT-MTOR Signaling, Growth Factor Signaling and Hypoxia and others. Garden Cress is recommended for Anaplastic Oligoastrocytoma when ongoing cancer treatment is Temozolomide. This is because Garden Cress modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Temozolomide.

Some of the active ingredients or bioactives in vegetable Carob are Apigenin, Curcumin, Quercetin, Daidzein, Lupeol. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Carob is not recommended for Anaplastic Oligoastrocytoma when ongoing cancer treatment is Temozolomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GARDEN CRESS IS RECOMMENDED OVER CAROB FOR Anaplastic Oligoastrocytoma AND TREATMENT Temozolomide.

Choose Fruit POMEGRANATE or PUMMELO?

Fruit Pomegranate contains many active ingredients or bioactives such as Apigenin, Curcumin, Quercetin, Ellagic Acid, Daidzein. These active ingredients manipulate various biochemical pathways like Growth Factor Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling and DNA Repair and others. Pomegranate is recommended for Anaplastic Oligoastrocytoma when ongoing cancer treatment is Temozolomide. This is because Pomegranate modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Temozolomide.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Caffeine, Quercetin, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Pummelo is not recommended for Anaplastic Oligoastrocytoma when ongoing cancer treatment is Temozolomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT POMEGRANATE IS RECOMMENDED OVER PUMMELO FOR Anaplastic Oligoastrocytoma AND TREATMENT Temozolomide.

Choose Nut COMMON WALNUT or MACADAMIA NUT?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Ellagic Acid, Daidzein, Lupeol. These active ingredients manipulate various biochemical pathways like Growth Factor Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling and DNA Repair and others. Common Walnut is recommended for Anaplastic Oligoastrocytoma when ongoing cancer treatment is Temozolomide. This is because Common Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Temozolomide.

Some of the active ingredients or bioactives in Macadamia Nut are Apigenin, Curcumin, Daidzein, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like DNA Repair, PI3K-AKT-MTOR Signaling and Growth Factor Signaling and others. Macadamia Nut is not recommended for Anaplastic Oligoastrocytoma when ongoing cancer treatment is Temozolomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON WALNUT IS RECOMMENDED OVER MACADAMIA NUT FOR Anaplastic Oligoastrocytoma AND TREATMENT Temozolomide.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Anaplastic Oligoastrocytoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or GARDEN RHUBARB?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and P53 Signaling and others. Giant Butterbur is recommended for risk of Anaplastic Oligoastrocytoma when associated genetic risk is EIF1AX. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Garden Rhubarb are Apigenin, Curcumin, Rhein, Emodin, Quercetin. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and Oncogenic Cancer Epigenetics and others. Garden Rhubarb is not recommended when risk of Anaplastic Oligoastrocytoma when associated genetic risk is EIF1AX because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER GARDEN RHUBARB FOR EIF1AX GENETIC RISK OF CANCER.

Choose Fruit NANCE or MEDLAR?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Hypoxia and P53 Signaling and others. Nance is recommended for risk of Anaplastic Oligoastrocytoma when associated genetic risk is EIF1AX. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Medlar are Apigenin, Curcumin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Angiogenesis and Stem Cell Signaling and others. Medlar is not recommended when risk of Anaplastic Oligoastrocytoma when associated genetic risk is EIF1AX because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER MEDLAR FOR EIF1AX GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or PUMPKIN SEEDS?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Angiogenesis, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and Apoptosis and others. Butternut is recommended for risk of Anaplastic Oligoastrocytoma when associated genetic risk is EIF1AX. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Pumpkin Seeds are Beta-sitosterol, Oleic Acid, Linolenic Acid, Stigmasterol, Vitamin B3. These active ingredients manipulate various biochemical pathways like Angiogenesis, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling and others. Pumpkin Seeds is not recommended when risk of Anaplastic Oligoastrocytoma when associated genetic risk is EIF1AX because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR EIF1AX GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Anaplastic Oligoastrocytoma. Anaplastic Oligoastrocytoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Anaplastic Oligoastrocytoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Garden Cress contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Anaplastic Oligoastrocytoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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