No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Anaplastic Oligoastrocytoma (WHO Grade 3) needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Almond and Apricot should be eaten when undergoing Procarbazine Treatment for Anaplastic Oligoastrocytoma. On the same lines, avoid foods like Cherry and Common Bean with treatment of Procarbazine for Anaplastic Oligoastrocytoma. Also, Black Seed supplement contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Procarbazine treatment and hence should be avoided.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Anaplastic Oligoastrocytoma.
What is Anaplastic Oligoastrocytoma (WHO Grade 3)?
Anaplastic Oligoastrocytoma is a variant of Oligoastrocytoma, a rare type of mixed glioma that has both oligodendroglioma and astrocytoma cells, and falls under WHO Grade 3. It is characterized by malignancy/cancerous histologic features or signs of rapid growth including increased cellularity, abnormal appearance of cell nuclei, growth of cells in multiple shapes and sizes, etc. The incidence rate of this cancer is only 0.06 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 48 years of age, however, it can occur in people of any age. It is slightly more commonly found in women as compared to men.
Anaplastic Oligoastrocytoma (WHO Grade 3) has prevalence of certain genetic changes. Some of the genes such as IDH1, TP53, ATRX, and CIC are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Anaplastic Oligoastrocytoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Anaplastic Oligoastrocytoma (WHO Grade 3). Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Anaplastic Oligoastrocytoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Anaplastic Oligoastrocytoma nutrition may have to be redesigned.
Why Eating Right Matters for Anaplastic Oligoastrocytoma (WHO Grade 3)?
In Anaplastic Oligoastrocytoma, activation or inhibition of some of the biochemical pathways including Hypoxia, PI3K-AKT-MTOR Signaling, DNA Repair, Cancer Epigenetics, MAPK Signaling and Carbohydrate Metabolism plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Anaplastic Oligoastrocytoma (WHO Grade 3), eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Procarbazine treatment for Anaplastic Oligoastrocytoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Anaplastic Oligoastrocytoma considering only one specific treatment.
Foods to Avoid
Cherry : Cherry contains active ingredients such as Genistein, Salicylic Acid, Linolenic Acid and others. Genistein interferes with the impact of Procarbazine in Anaplastic Oligoastrocytoma by activating a specific biological process called DNA Repair. Hence, avoid foods like Cherry with Procarbazine treatment for Anaplastic Oligoastrocytoma. (S Fan et al, Br J Cancer., 2006; Juliana Ferreira de Sousa et al, Genet Mol Biol., 2019; Martin J van den Bent et al, J Clin Oncol., 2013)
Common Bean : Common Bean contains active ingredients such as Apigenin, Genistein, Linolenic Acid and others. Apigenin interferes with the impact of Procarbazine in Anaplastic Oligoastrocytoma by activating a specific biological process called DNA Repair. Hence, do not eat Common Bean with Procarbazine treatment for this cancer. (Sreemanti Das et al, J Acupunct Meridian Stud., 2013; Juliana Ferreira de Sousa et al, Genet Mol Biol., 2019; Martin J van den Bent et al, J Clin Oncol., 2013)
Foods to Eat
Almond : Almond contains active ingredients like Salicylic Acid, Vitamin E and Stigmasterol. Intake of Salicylic Acid along with Procarbazine treatment for Anaplastic Oligoastrocytoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Almond hence should be eaten with Procarbazine treatment for this cancer. (Zhihang Chen et al, Mol Med., 2020; Martin J van den Bent et al, J Clin Oncol., 2013)
Apricot : Apricot contains active ingredients like Salicylic Acid, Stigmasterol and Quercetin. Intake of Salicylic Acid along with Procarbazine treatment for Anaplastic Oligoastrocytoma (WHO Grade 3) causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Apricot hence should be eaten with Procarbazine treatment for this cancer. (Zhihang Chen et al, Mol Med., 2020; Martin J van den Bent et al, J Clin Oncol., 2013)
Should I take this Nutritional Supplement for Anaplastic Oligoastrocytoma?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Procarbazine treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Procarbazine treatment efficacy in Anaplastic Oligoastrocytoma. Hence, avoid taking Black seed supplements with Procarbazine treatment for this cancer. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Pius S Fasinu et al, Front Oncol., 2019; Martin J van den Bent et al, J Clin Oncol., 2013)
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Anaplastic Oligoastrocytoma (WHO Grade 3)?
In the initial stages, most cancers including Anaplastic Oligoastrocytoma (WHO Grade 3) may not cause any signs or symptoms. However, as the disease progresses, it may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Anaplastic Oligoastrocytoma.
- Weakness or numbness in the arms or legs
- Speech problems
- Memory loss
- Vision problems
- Changes in personality
- Cognitive impairments
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Anaplastic Oligoastrocytoma.
What are the Treatment Options for Anaplastic Oligoastrocytoma?
The treatment for Anaplastic Oligoastrocytoma (WHO Grade 3) may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for this cancer include:
- Radiation therapy
- Palliative Care
Surgery or surgery followed by radiation is the most common treatment regimen for Anaplastic Oligoastrocytoma. Radiotherapy helps to shrink the tumor. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Anaplastic Oligoastrocytoma.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Anaplastic Oligoastrocytoma (WHO Grade 3).
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.